6p7r - Revision history

OCA at 07:24, 11 October 2023

OCA — Wed, 11 Oct 2023 07:24:34 GMT

←Older revision		Revision as of 07:24, 11 October 2023
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	<StructureSection load='6p7r' size='340' side='right'caption='[[6p7r]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='6p7r' size='340' side='right'caption='[[6p7r]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6p7r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P7R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6P7R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6p7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P7R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6p7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p7r OCA], [~~http~~://pdbe.org/6p7r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6p7r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6p7r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6p7r ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p7r OCA], [https://pdbe.org/6p7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p7r RCSB], [https://www.ebi.ac.uk/pdbsum/6p7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p7r ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9F5Q9_VIBCL Q9F5Q9_VIBCL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6p7r" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6p7r" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ToxT\|ToxT]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Cruite, J T~~]]	+	[[Category: Vibrio cholerae]]
-	[[Category: ~~Kull, F J~~]]	+	[[Category: Cruite JT]]
-	[[Category: ~~Arac]]~~	+	[[Category: Kull FJ]]
-	~~[[Category: Cholerae]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Virulence regulation]]~~	+
-	~~[[Category: Xyl~~]]	+

OCA at 08:19, 1 January 2020

OCA — Wed, 01 Jan 2020 08:19:59 GMT

←Older revision		Revision as of 08:19, 1 January 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6p7r is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of unsaturated fatty acid bound wild-type ToxT from Vibrio cholerae strain SCE256==
		+	<StructureSection load='6p7r' size='340' side='right'caption='[[6p7r]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6p7r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P7R FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p7r OCA], [http://pdbe.org/6p7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p7r RCSB], [http://www.ebi.ac.uk/pdbsum/6p7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p7r ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The AraC/XylS-family transcriptional regulator ToxT is the master virulence activator of Vibrio cholerae, the gram-negative bacterial pathogen that causes the diarrheal disease cholera. Unsaturated fatty acids (UFAs) found in bile inhibit the activity of ToxT. Crystal structures of inhibited ToxT bound to UFA or synthetic inhibitors have been reported, but no structure of ToxT in an active conformation had been determined. Here we present the 2.5 A structure of ToxT without an inhibitor. The structure suggests release of UFA or inhibitor leads to an increase in flexibility, allowing ToxT to adopt an active conformation that is able to dimerize and bind DNA. Small-angle X-ray scattering was used to validate a structural model of an open ToxT dimer bound to the cholera toxin promoter. The results presented here provide a detailed structural mechanism for virulence gene regulation in V. cholerae by the UFA components of bile and other synthetic ToxT inhibitors.

-	~~Authors:~~ Cruite, ~~J.T.~~, ~~Kull~~, F.J.	+	Structural basis for virulence regulation in Vibrio cholerae by unsaturated fatty acid components of bile.,Cruite JT, Kovacikova G, Clark KA, Woodbrey AK, Skorupski K, Kull FJ Commun Biol. 2019 Nov 28;2:440. doi: 10.1038/s42003-019-0686-x. eCollection 2019. PMID:31815195<ref>PMID:31815195</ref>

-	~~Description: Crystal structure~~ of ~~unsaturated fatty acid bound wild~~-~~type ToxT from Vibrio cholerae strain SCE256~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Kull~~, F.J]]	+	<div class="pdbe-citations 6p7r" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Cruite~~, J.T]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cruite, J T]]
		+	[[Category: Kull, F J]]
		+	[[Category: Arac]]
		+	[[Category: Cholerae]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Virulence regulation]]
		+	[[Category: Xyl]]

OCA at 04:22, 24 July 2019

OCA — Wed, 24 Jul 2019 04:22:01 GMT

←Older revision		Revision as of 04:22, 24 July 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6p7r is ON HOLD	+	The entry 6p7r is ON HOLD until Paper Publication

	Authors: Cruite, J.T., Kull, F.J.		Authors: Cruite, J.T., Kull, F.J.

OCA: Protected "6p7r" [edit=sysop:move=sysop]

OCA — Wed, 12 Jun 2019 04:07:39 GMT

Protected "6p7r" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:07, 12 June 2019

OCA: New page: '''Unreleased structure''' The entry 6p7r is ON HOLD Authors: Cruite, J.T., Kull, F.J. Description: Crystal structure of unsaturated fatty acid bound wild-type ToxT from Vibrio cholera...

OCA — Wed, 12 Jun 2019 04:07:38 GMT

New page: '''Unreleased structure''' The entry 6p7r is ON HOLD Authors: Cruite, J.T., Kull, F.J. Description: Crystal structure of unsaturated fatty acid bound wild-type ToxT from Vibrio cholera...

New page

'''Unreleased structure'''

The entry 6p7r is ON HOLD

Authors: Cruite, J.T., Kull, F.J.

Description: Crystal structure of unsaturated fatty acid bound wild-type ToxT from Vibrio cholerae strain SCE256
[[Category: Unreleased Structures]]
[[Category: Kull, F.J]]
[[Category: Cruite, J.T]]