6p8m - Revision history

OCA at 07:25, 11 October 2023

OCA — Wed, 11 Oct 2023 07:25:01 GMT

←Older revision		Revision as of 07:25, 11 October 2023
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	<StructureSection load='6p8m' size='340' side='right'caption='[[6p8m]], [[Resolution\|resolution]] 3.59Å' scene=''>		<StructureSection load='6p8m' size='340' side='right'caption='[[6p8m]], [[Resolution\|resolution]] 3.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6p8m]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P8M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6P8M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6p8m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P8M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.594Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6p8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p8m OCA], [~~http~~://pdbe.org/6p8m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6p8m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6p8m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6p8m ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p8m OCA], [https://pdbe.org/6p8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p8m RCSB], [https://www.ebi.ac.uk/pdbsum/6p8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p8m ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/M4Q8P8_9HIV1 M4Q8P8_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6p8m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6p8m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Gp120 3D structures\|Gp120 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]	+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Pancera, M]]	+	[[Category: Pancera M]]
-	[[Category: Weidle, C]]	+	[[Category: Weidle C]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunization~~]]	+

OCA at 09:36, 8 January 2020

OCA — Wed, 08 Jan 2020 09:36:43 GMT

←Older revision		Revision as of 09:36, 8 January 2020
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p8m OCA], [http://pdbe.org/6p8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p8m RCSB], [http://www.ebi.ac.uk/pdbsum/6p8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p8m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p8m OCA], [http://pdbe.org/6p8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p8m RCSB], [http://www.ebi.ac.uk/pdbsum/6p8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p8m ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Broadly HIV-1 neutralizing VRC01 class antibodies target the CD4-binding site of Env. They are derived from VH1-2( *)02 antibody heavy chains paired with rare light chains expressing 5-amino acid-long CDRL3s. They have been isolated from infected subjects but have not yet been elicited by immunization. Env-derived immunogens capable of binding the germline forms of VRC01 B cell receptors on naive B cells have been designed and evaluated in knockin mice. However, the elicited antibodies cannot bypass glycans present on the conserved position N276 of Env, which restricts access to the CD4-binding site. Efforts to guide the appropriate maturation of these antibodies by sequential immunization have not yet been successful. Here, we report on a two-step immunization scheme that leads to the maturation of VRC01-like antibodies capable of accommodating the N276 glycan and displaying autologous tier 2 neutralizing activities. Our results are relevant to clinical trials aiming to elicit VRC01 antibodies.
		+
		+	Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization.,Parks KR, MacCamy AJ, Trichka J, Gray M, Weidle C, Borst AJ, Khechaduri A, Takushi B, Agrawal P, Guenaga J, Wyatt RT, Coler R, Seaman M, LaBranche C, Montefiori DC, Veesler D, Pancera M, McGuire A, Stamatatos L Cell Rep. 2019 Dec 3;29(10):3060-3072.e7. doi: 10.1016/j.celrep.2019.10.071. PMID:31801073<ref>PMID:31801073</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6p8m" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:22, 18 December 2019

OCA — Wed, 18 Dec 2019 12:22:12 GMT

←Older revision		Revision as of 12:22, 18 December 2019
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	<StructureSection load='6p8m' size='340' side='right'caption='[[6p8m]], [[Resolution\|resolution]] 3.59Å' scene=''>		<StructureSection load='6p8m' size='340' side='right'caption='[[6p8m]], [[Resolution\|resolution]] 3.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6p8m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P8M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6p8m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P8M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p8m OCA], [http://pdbe.org/6p8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p8m RCSB], [http://www.ebi.ac.uk/pdbsum/6p8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p8m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p8m OCA], [http://pdbe.org/6p8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p8m RCSB], [http://www.ebi.ac.uk/pdbsum/6p8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p8m ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Pancera, M]]		[[Category: Pancera, M]]
	[[Category: Weidle, C]]		[[Category: Weidle, C]]

OCA at 15:29, 20 November 2019

OCA — Wed, 20 Nov 2019 15:29:46 GMT

←Older revision		Revision as of 15:29, 20 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6p8m ~~is ON HOLD until Paper Publication~~	+	==Crystal Structure of Antibody P-p3b3 A60C Heavy Chain in Complex with 426c HIV-1 gp120 core G459C==
-		+	<StructureSection load='6p8m' size='340' side='right'caption='[[6p8m]], [[Resolution\|resolution]] 3.59Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6p8m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P8M FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p8m OCA], [http://pdbe.org/6p8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p8m RCSB], [http://www.ebi.ac.uk/pdbsum/6p8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p8m ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pancera, M]]
		+	[[Category: Weidle, C]]
		+	[[Category: Antibody]]
		+	[[Category: Immune system]]
		+	[[Category: Immunization]]

OCA at 04:22, 24 July 2019

OCA — Wed, 24 Jul 2019 04:22:21 GMT

←Older revision		Revision as of 04:22, 24 July 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6p8m is ON HOLD	+	The entry 6p8m is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6p8m" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2019 04:16:51 GMT

Protected "6p8m" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:16, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6p8m is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Jun 2019 04:16:50 GMT

New page: '''Unreleased structure''' The entry 6p8m is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6p8m is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]