6pdl - Revision history

OCA at 07:27, 11 October 2023

OCA — Wed, 11 Oct 2023 07:27:33 GMT

←Older revision		Revision as of 07:27, 11 October 2023
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	<StructureSection load='6pdl' size='340' side='right'caption='[[6pdl]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6pdl' size='340' side='right'caption='[[6pdl]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pdl]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Equine_morbillivirus Equine morbillivirus~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PDL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pdl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Hendra_henipavirus Hendra henipavirus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PDL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EFNB2, EPLG5, HTKL, LERK5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pdl OCA], [~~http~~://pdbe.org/6pdl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pdl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pdl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pdl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pdl OCA], [https://pdbe.org/6pdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pdl RCSB], [https://www.ebi.ac.uk/pdbsum/6pdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pdl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/EFNB2_HUMAN EFNB2_HUMAN]] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.<ref>PMID:12734395</ref>	+	[https://www.uniprot.org/uniprot/EFNB2_HUMAN EFNB2_HUMAN] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.<ref>PMID:12734395</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6pdl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6pdl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ephrin\|Ephrin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Equine morbillivirus~~]]	+	[[Category: Hendra henipavirus]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Nikolov~~, D B~~]]	+	[[Category: Nikolov DB]]
-	[[Category: Xu, K]]	+	[[Category: Xu K]]
-	~~[[Category: Attachment]]~~	+
-	~~[[Category: G protein]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Viral protein-signaling protein complex~~]]	+

OCA at 12:23, 18 December 2019

OCA — Wed, 18 Dec 2019 12:23:35 GMT

←Older revision		Revision as of 12:23, 18 December 2019
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	<StructureSection load='6pdl' size='340' side='right'caption='[[6pdl]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6pdl' size='340' side='right'caption='[[6pdl]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pdl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pdl]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Equine_morbillivirus Equine morbillivirus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PDL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EFNB2, EPLG5, HTKL, LERK5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pdl OCA], [http://pdbe.org/6pdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pdl RCSB], [http://www.ebi.ac.uk/pdbsum/6pdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pdl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pdl OCA], [http://pdbe.org/6pdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pdl RCSB], [http://www.ebi.ac.uk/pdbsum/6pdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pdl ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Equine morbillivirus]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Nikolov, D B]]		[[Category: Nikolov, D B]]

OCA at 06:52, 27 November 2019

OCA — Wed, 27 Nov 2019 06:52:18 GMT

←Older revision		Revision as of 06:52, 27 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6pdl is ~~ON HOLD~~	+	==Crystal Structure of Hendra Virus Attachment G Glycoprotein in Complex with Receptor Ephrin-B2==
		+	<StructureSection load='6pdl' size='340' side='right'caption='[[6pdl]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6pdl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PDL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pdl OCA], [http://pdbe.org/6pdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pdl RCSB], [http://www.ebi.ac.uk/pdbsum/6pdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pdl ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EFNB2_HUMAN EFNB2_HUMAN]] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.<ref>PMID:12734395</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hendra virus and Nipah virus, comprising the genus Henipavirus, are recently emerged, highly pathogenic and often lethal zoonotic agents against which there are no approved therapeutics. Two surface glycoproteins, the attachment (G) and fusion (F), mediate host cell entry. The crystal structures of the Hendra G glycoprotein alone and in complex with the ephrin-B2 receptor reveal that henipavirus uses Tryptophan 122 on ephrin-B2/B3 as a "latch" to facilitate the G-receptor association. Structural-based mutagenesis of residues in the Hendra G glycoprotein at the receptor binding interface document their importance for viral attachments and entry, and suggest that the stability of the Hendra-G-ephrin attachment complex does not strongly correlate with the efficiency of viral entry. In addition, our data indicates that conformational rearrangements of the G glycoprotein head domain upon receptor binding may be the trigger leading to the activation of the viral F fusion glycoprotein during virus infection.

-	~~Authors: Xu~~, K., ~~Nikolov~~, D.B.	+	New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2.,Xu K, Chan YP, Rajashankar KR, Khetawat D, Yan L, Kolev MV, Broder CC, Nikolov DB PLoS One. 2012;7(11):e48742. doi: 10.1371/journal.pone.0048742. Epub 2012 Nov 5. PMID:23144952<ref>PMID:23144952</ref>

-	~~Description: Crystal Structure~~ of ~~Hendra Virus Attachment G Glycoprotein in Complex with Receptor Ephrin~~-B2	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6pdl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Nikolov, D B]]
	[[Category: Xu, K]]		[[Category: Xu, K]]
-	[[Category: ~~Nikolov, D.B~~]]	+	[[Category: Attachment]]
		+	[[Category: G protein]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Receptor]]
		+	[[Category: Viral protein]]
		+	[[Category: Viral protein-signaling protein complex]]

OCA: Protected "6pdl" [edit=sysop:move=sysop]

OCA — Wed, 26 Jun 2019 05:19:40 GMT

Protected "6pdl" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:19, 26 June 2019

OCA: New page: '''Unreleased structure''' The entry 6pdl is ON HOLD Authors: Xu, K., Nikolov, D.B. Description: Crystal Structure of Hendra Virus Attachment G Glycoprotein in Complex with Receptor Ep...

OCA — Wed, 26 Jun 2019 05:19:39 GMT

New page: '''Unreleased structure''' The entry 6pdl is ON HOLD Authors: Xu, K., Nikolov, D.B. Description: Crystal Structure of Hendra Virus Attachment G Glycoprotein in Complex with Receptor Ep...

New page

'''Unreleased structure'''

The entry 6pdl is ON HOLD

Authors: Xu, K., Nikolov, D.B.

Description: Crystal Structure of Hendra Virus Attachment G Glycoprotein in Complex with Receptor Ephrin-B2
[[Category: Unreleased Structures]]
[[Category: Xu, K]]
[[Category: Nikolov, D.B]]