6pfv - Revision history

OCA at 07:28, 11 October 2023

OCA — Wed, 11 Oct 2023 07:28:37 GMT

←Older revision		Revision as of 07:28, 11 October 2023
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	<StructureSection load='6pfv' size='340' side='right'caption='[[6pfv]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6pfv' size='340' side='right'caption='[[6pfv]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pfv]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strvp Strvp~~] and [~~http~~://en.wikipedia.org/wiki/~~Streptomyces_sp._pansc19~~ Streptomyces ~~sp. pansc19~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PFV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pfv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._PanSC19 Streptomyces sp. PanSC19] and [https://en.wikipedia.org/wiki/Streptomyces_venezuelae_ATCC_10712 Streptomyces venezuelae ATCC 10712]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PFV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pfj\|6pfj]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SVEN_3933 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=953739 STRVP]), EDD98_3685 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1520455 Streptomyces sp. PanSC19])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pfv OCA], [https://pdbe.org/6pfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pfv RCSB], [https://www.ebi.ac.uk/pdbsum/6pfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pfv ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pfv OCA], [~~http~~://pdbe.org/6pfv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pfv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pfv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pfv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~A0A3N1Q704_9ACTN A0A3N1Q704_9ACTN]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.[RuleBase:RU362124~~]	+	[https://www.uniprot.org/uniprot/F2RFR7_STRVP F2RFR7_STRVP]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Streptomyces sp. ~~pansc19~~]]	+	[[Category: Streptomyces sp. PanSC19]]
-	[[Category: ~~Strvp~~]]	+	[[Category: Streptomyces venezuelae ATCC 10712]]
-	[[Category: Schumacher~~, M A]]~~	+	[[Category: Schumacher MA]]
-	~~[[Category: Anti-sigma]]~~	+
-	~~[[Category: C-di-gmp]]~~	+
-	~~[[Category: Rsig]]~~	+
-	~~[[Category: Sigma]]~~	+
-	~~[[Category: Streptomyce]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Whig~~]]	+

OCA at 07:27, 19 February 2020

OCA — Wed, 19 Feb 2020 07:27:56 GMT

←Older revision		Revision as of 07:27, 19 February 2020
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 6pfv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6pfv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sigma factor 3D structures\|Sigma factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:25, 18 December 2019

OCA — Wed, 18 Dec 2019 12:25:57 GMT

←Older revision		Revision as of 12:25, 18 December 2019
Line 3:		Line 3:
	<StructureSection load='6pfv' size='340' side='right'caption='[[6pfv]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6pfv' size='340' side='right'caption='[[6pfv]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pfv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PFV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pfv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Strvp Strvp] and [http://en.wikipedia.org/wiki/Streptomyces_sp._pansc19 Streptomyces sp. pansc19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PFV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pfj\|6pfj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pfj\|6pfj]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SVEN_3933 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=953739 STRVP]), EDD98_3685 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1520455 Streptomyces sp. PanSC19])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pfv OCA], [http://pdbe.org/6pfv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pfv RCSB], [http://www.ebi.ac.uk/pdbsum/6pfv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pfv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pfv OCA], [http://pdbe.org/6pfv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pfv RCSB], [http://www.ebi.ac.uk/pdbsum/6pfv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pfv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/A0A3N1Q704_9ACTN A0A3N1Q704_9ACTN]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.[RuleBase:RU362124]		[[http://www.uniprot.org/uniprot/A0A3N1Q704_9ACTN A0A3N1Q704_9ACTN]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.[RuleBase:RU362124]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Streptomyces are our primary source of antibiotics, produced concomitantly with the transition from vegetative growth to sporulation in a complex developmental life cycle. We previously showed that the signaling molecule c-di-GMP binds BldD, a master repressor, to control initiation of development. Here we demonstrate that c-di-GMP also intervenes later in development to control differentiation of the reproductive hyphae into spores by arming a novel anti-sigma (RsiG) to bind and sequester a sporulation-specific sigma factor (sigma(WhiG)). We present the structure of the RsiG-(c-di-GMP)2-sigma(WhiG) complex, revealing an unusual, partially intercalated c-di-GMP dimer bound at the RsiG-sigma(WhiG) interface. RsiG binds c-di-GMP in the absence of sigma(WhiG), employing a novel E(X)3S(X)2R(X)3Q(X)3D motif repeated on each helix of a coiled coil. Further studies demonstrate that c-di-GMP is essential for RsiG to inhibit sigma(WhiG). These findings reveal a newly described control mechanism for sigma-anti-sigma complex formation and establish c-di-GMP as the central integrator of Streptomyces development.
		+
		+	c-di-GMP Arms an Anti-sigma to Control Progression of Multicellular Differentiation in Streptomyces.,Gallagher KA, Schumacher MA, Bush MJ, Bibb MJ, Chandra G, Holmes NA, Zeng W, Henderson M, Zhang H, Findlay KC, Brennan RG, Buttner MJ Mol Cell. 2019 Nov 27. pii: S1097-2765(19)30835-4. doi:, 10.1016/j.molcel.2019.11.006. PMID:31810759<ref>PMID:31810759</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6pfv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Streptomyces sp. pansc19]]
		+	[[Category: Strvp]]
	[[Category: Schumacher, M A]]		[[Category: Schumacher, M A]]
	[[Category: Anti-sigma]]		[[Category: Anti-sigma]]

OCA at 11:07, 13 November 2019

OCA — Wed, 13 Nov 2019 11:07:13 GMT

←Older revision		Revision as of 11:07, 13 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6pfv is ON HOLD until Paper Publication~~	+	==Structure of S. venezuelae RisG-WhiG-c-di-GMP complex: orthorhombic crystal form==
-		+	<StructureSection load='6pfv' size='340' side='right'caption='[[6pfv]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors: Schumacher, M.A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6pfv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PFV FirstGlance]. <br>
-	~~Description:~~ Structure of S. venezuelae RisG-WhiG-c-di-GMP complex: orthorhombic crystal form	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pfj\|6pfj]]</td></tr>
-	[[Category: Schumacher, M.A]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pfv OCA], [http://pdbe.org/6pfv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pfv RCSB], [http://www.ebi.ac.uk/pdbsum/6pfv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pfv ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A3N1Q704_9ACTN A0A3N1Q704_9ACTN]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.[RuleBase:RU362124]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Schumacher, M A]]
		+	[[Category: Anti-sigma]]
		+	[[Category: C-di-gmp]]
		+	[[Category: Rsig]]
		+	[[Category: Sigma]]
		+	[[Category: Streptomyce]]
		+	[[Category: Transcription]]
		+	[[Category: Whig]]

OCA at 07:11, 2 October 2019

OCA — Wed, 02 Oct 2019 07:11:19 GMT

←Older revision		Revision as of 07:11, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pfv is ON HOLD	+	The entry 6pfv is ON HOLD until Paper Publication

	Authors: Schumacher, M.A.		Authors: Schumacher, M.A.

OCA: Protected "6pfv" [edit=sysop:move=sysop]

OCA — Wed, 03 Jul 2019 04:16:49 GMT

Protected "6pfv" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:16, 3 July 2019

OCA: New page: '''Unreleased structure''' The entry 6pfv is ON HOLD Authors: Schumacher, M.A. Description: Structure of S. venezuelae RisG-WhiG-c-di-GMP complex: orthorhombic crystal form [[Category:...

OCA — Wed, 03 Jul 2019 04:16:48 GMT

New page: '''Unreleased structure''' The entry 6pfv is ON HOLD Authors: Schumacher, M.A. Description: Structure of S. venezuelae RisG-WhiG-c-di-GMP complex: orthorhombic crystal form [[Category:...

New page

'''Unreleased structure'''

The entry 6pfv is ON HOLD

Authors: Schumacher, M.A.

Description: Structure of S. venezuelae RisG-WhiG-c-di-GMP complex: orthorhombic crystal form
[[Category: Unreleased Structures]]
[[Category: Schumacher, M.A]]