6pgw - Revision history

OCA at 07:29, 11 October 2023

OCA — Wed, 11 Oct 2023 07:29:15 GMT

←Older revision		Revision as of 07:29, 11 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6pgw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PGW FirstGlance]. <br>		<table><tr><td colspan='2'>[[6pgw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PGW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pgw OCA], [https://pdbe.org/6pgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pgw RCSB], [https://www.ebi.ac.uk/pdbsum/6pgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pgw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pgw OCA], [https://pdbe.org/6pgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pgw RCSB], [https://www.ebi.ac.uk/pdbsum/6pgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pgw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/F8W3X3_DANRE F8W3X3_DANRE]]	+	[https://www.uniprot.org/uniprot/F8W3X3_DANRE F8W3X3_DANRE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 03:00, 8 September 2022

OCA — Thu, 08 Sep 2022 03:00:21 GMT

←Older revision		Revision as of 03:00, 8 September 2022
Line 3:		Line 3:
	<StructureSection load='6pgw' size='340' side='right'caption='[[6pgw]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6pgw' size='340' side='right'caption='[[6pgw]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pgw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PGW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pgw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PGW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcdh19, wu:fc83e05 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pgw OCA], [https://pdbe.org/6pgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pgw RCSB], [https://www.ebi.ac.uk/pdbsum/6pgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pgw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pgw OCA], [https://pdbe.org/6pgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pgw RCSB], [https://www.ebi.ac.uk/pdbsum/6pgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pgw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/F8W3X3_DANRE F8W3X3_DANRE]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cooper~~, S R~~]]	+	[[Category: Cooper SR]]
-	[[Category: Hudson~~, J D~~]]	+	[[Category: Hudson JD]]
-	[[Category: Sotomayor, M]]	+	[[Category: Sotomayor M]]
-	~~[[Category: Calcium-binding]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Epilepsy]]~~	+
-	~~[[Category: Pcdh19]]~~	+
-	~~[[Category: Protocadherin~~]]	+

OCA at 06:24, 1 December 2021

OCA — Wed, 01 Dec 2021 06:24:04 GMT

←Older revision		Revision as of 06:24, 1 December 2021
Line 1:		Line 1:

	==Crystal structure of zebrafish Protocadherin-19 EC3-6==		==Crystal structure of zebrafish Protocadherin-19 EC3-6==
-	<StructureSection load='6pgw' size='340' side='right'caption='[[6pgw]]' scene=''>	+	<StructureSection load='6pgw' size='340' side='right'caption='[[6pgw]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6PGW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pgw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PGW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pgw OCA], [~~http~~://pdbe.org/6pgw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pgw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pgw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pgw ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcdh19, wu:fc83e05 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pgw OCA], [https://pdbe.org/6pgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pgw RCSB], [https://www.ebi.ac.uk/pdbsum/6pgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pgw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cadherin superfamily members play a critical role in differential adhesion during neurodevelopment, and their disruption has been linked to several neurodevelopmental disorders. Mutations in protocadherin-19 (PCDH19), a member of the delta-protocadherin subfamily of cadherins, cause a unique form of epilepsy called PCDH19 clustering epilepsy. While PCDH19 and other non-clustered delta-protocadherins form multimers with other members of the cadherin superfamily to alter adhesiveness, the specific protein surfaces responsible for these interactions are unknown. Only portions of the PCDH19 extracellular domain structure had been solved previously. Here, we present a structure of the missing segment from zebrafish Protocadherin-19 (Pcdh19) and create a complete ectodomain model. This model shows the structural environment for 97% of disease-causing missense mutations and reveals two potential surfaces for intermolecular interactions that could modify Pcdh19's adhesive strength and specificity.
		+
		+	A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites.,Hudson JD, Tamilselvan E, Sotomayor M, Cooper SR Structure. 2021 Oct 7;29(10):1128-1143.e4. doi: 10.1016/j.str.2021.07.006. Epub, 2021 Sep 13. PMID:34520737<ref>PMID:34520737</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6pgw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cooper SR]]	+	[[Category: Cooper, S R]]
-	[[Category: Hudson JD]]	+	[[Category: Hudson, J D]]
-	[[Category: Sotomayor M]]	+	[[Category: Sotomayor, M]]
		+	[[Category: Calcium-binding]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Epilepsy]]
		+	[[Category: Pcdh19]]
		+	[[Category: Protocadherin]]

OCA at 06:43, 30 December 2020

OCA — Wed, 30 Dec 2020 06:43:14 GMT

←Older revision		Revision as of 06:43, 30 December 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6pgw is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of zebrafish Protocadherin-19 EC3-6==
-		+	<StructureSection load='6pgw' size='340' side='right'caption='[[6pgw]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PGW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pgw OCA], [http://pdbe.org/6pgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pgw RCSB], [http://www.ebi.ac.uk/pdbsum/6pgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pgw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cooper SR]]
		+	[[Category: Hudson JD]]
		+	[[Category: Sotomayor M]]

OCA at 04:07, 10 July 2019

OCA — Wed, 10 Jul 2019 04:07:26 GMT

←Older revision		Revision as of 04:07, 10 July 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pgw is ON HOLD	+	The entry 6pgw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6pgw" [edit=sysop:move=sysop]

OCA — Wed, 03 Jul 2019 04:19:20 GMT

Protected "6pgw" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:19, 3 July 2019

OCA: New page: '''Unreleased structure''' The entry 6pgw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Jul 2019 04:19:19 GMT

New page: '''Unreleased structure''' The entry 6pgw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6pgw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]