6pji - Revision history

OCA at 07:30, 11 October 2023

OCA — Wed, 11 Oct 2023 07:30:42 GMT

←Older revision		Revision as of 07:30, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6pji' size='340' side='right'caption='[[6pji]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6pji' size='340' side='right'caption='[[6pji]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PJI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PJI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OO4:methyl+[(1S)-1-cyclopropyl-2-({(2S,3S,5S)-5-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxy-1,6-diphenylhexan-2-yl}amino)-2-oxoethyl]carbamate'>OO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OO4:methyl+[(1S)-1-cyclopropyl-2-({(2S,3S,5S)-5-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxy-1,6-diphenylhexan-2-yl}amino)-2-oxoethyl]carbamate'>OO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pji OCA], [https://pdbe.org/6pji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pji RCSB], [https://www.ebi.ac.uk/pdbsum/6pji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pji ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pji OCA], [https://pdbe.org/6pji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pji RCSB], [https://www.ebi.ac.uk/pdbsum/6pji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pji ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/POL_HV1N5 POL_HV1N5] Gag-Pol polyprotein and Gag polyprotein may regulate their own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, Gag-Pol and Gag would promote translation, whereas at high concentration, the polyproteins encapsidate genomic RNA and then shutt off translation (By similarity). Matrix protein p17 has two main functions: in infected cell, it targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus. The second function is to play a role in nuclear localization of the viral genome at the very start of cell infection. Matrix protein is the part of the pre-integration complex. It binds in the cytoplasm the human BAF protein which prevent autointegration of the viral genome, and might be included in virions at the ration of zero to 3 BAF dimer per virion. The myristoylation signal and the NLS thus exert conflicting influences its subcellular localization. The key regulation of these motifs might be phosphorylation of a portion of MA molecules on the C-terminal tyrosine at the time of virus maturation, by virion-associated cellular tyrosine kinase. Implicated in the release from host cell mediated by Vpu (By similarity). Capsid protein p24 forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is disassembled soon after virion entry. Interaction with human PPIA/CYPA protects the virus from restriction by human TRIM5-alpha and from an unknown antiviral activity in human cells. This capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species (By similarity). Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. Facilitates rearangement of nucleic acid secondary structure during retrotranscription of genomic RNA. This capability is referred to as nucleic acid chaperone activity (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell. Also cleaves Nef and Vif, probably concomitantly with viral structural proteins on maturation of virus particles (By similarity). Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that converts the viral RNA genome into dsDNA in the cytoplasm, shortly after virus entry into the cell. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3' to 5' endonucleasic mode. Conversion of viral genomic RNA into dsDNA requires many steps. A tRNA(3)-Lys binds to the primer-binding site (PBS) situated at the 5'-end of the viral RNA. RT uses the 3' end of the tRNA primer to perform a short round of RNA-dependent minus-strand DNA synthesis. The reading proceeds through the U5 region and ends after the repeated (R) region which is present at both ends of viral RNA. The portion of the RNA-DNA heteroduplex is digested by the RNase H, resulting in a ssDNA product attached to the tRNA primer. This ssDNA/tRNA hybridizes with the identical R region situated at the 3' end of viral RNA. This template exchange, known as minus-strand DNA strong stop transfer, can be either intra- or intermolecular. RT uses the 3' end of this newly synthesized short ssDNA to perform the RNA-dependent minus-strand DNA synthesis of the whole template. RNase H digests the RNA template except for two polypurine tracts (PPTs) situated at the 5'-end and near the center of the genome. It is not clear if both polymerase and RNase H activities are simultaneous. RNase H probably can proceed both in a polymerase-dependent (RNA cut into small fragments by the same RT performing DNA synthesis) and a polymerase-independent mode (cleavage of remaining RNA fragments by free RTs). Secondly, RT performs DNA-directed plus-strand DNA synthesis using the PPTs that have not been removed by RNase H as primers. PPTs and tRNA primers are then removed by RNase H. The 3' and 5' ssDNA PBS regions hybridize to form a circular dsDNA intermediate. Strand displacement synthesis by RT to the PBS and PPT ends produces a blunt ended, linear dsDNA copy of the viral genome that includes long terminal repeats (LTRs) at both ends (By similarity). Integrase catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein, Vpr and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step, the PIC enters cell nucleus. This process is mediated through integrase and Vpr proteins, and allows the virus to infect a non dividing cell. This ability to enter the nucleus is specific of lentiviruses, other retroviruses cannot and rely on cell division to access cell chromosomes. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The 5'-ends are produced by integrase-catalyzed staggered cuts, 5 bp apart. A Y-shaped, gapped, recombination intermediate results, with the 5'-ends of the viral DNA strands and the 3' ends of target DNA strands remaining unjoined, flanking a gap of 5 bp. The last step is viral DNA integration into host chromosome. This involves host DNA repair synthesis in which the 5 bp gaps between the unjoined strands are filled in and then ligated. Since this process occurs at both cuts flanking the HIV genome, a 5 bp duplication of host DNA is produced at the ends of HIV-1 integration. Alternatively, Integrase may catalyze the excision of viral DNA just after strand transfer, this is termed disintegration (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ali, A]]	+	[[Category: Ali A]]
-	[[Category: Henes, M]]	+	[[Category: Henes M]]
-	[[Category: Kosovrasti, K]]	+	[[Category: Kosovrasti K]]
-	[[Category: KurtYilmaz, N]]	+	[[Category: KurtYilmaz N]]
-	[[Category: Lee~~, S K~~]]	+	[[Category: Lee SK]]
-	[[Category: Lockbaum~~, G J~~]]	+	[[Category: Lockbaum GJ]]
-	[[Category: Nalivaika~~, E A~~]]	+	[[Category: Nalivaika EA]]
-	[[Category: Rusere~~, L N~~]]	+	[[Category: Rusere LN]]
-	[[Category: Schiffer~~, C A~~]]	+	[[Category: Schiffer CA]]
-	[[Category: Spielvogel, E]]	+	[[Category: Spielvogel E]]
-	[[Category: Swanstrom, R]]	+	[[Category: Swanstrom R]]
-	~~[[Category: Drug resistance]]~~	+
-	~~[[Category: Hiv]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase inhibitor complex]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Nl4-3 protease]]~~	+
-	~~[[Category: Protease inhibitor~~]]	+

OCA at 08:53, 18 February 2021

OCA — Thu, 18 Feb 2021 08:53:56 GMT

←Older revision		Revision as of 08:53, 18 February 2021
Line 3:		Line 3:
	<StructureSection load='6pji' size='340' side='right'caption='[[6pji]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6pji' size='340' side='right'caption='[[6pji]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pji]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PJI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6PJI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PJI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OO4:methyl+[(1S)-1-cyclopropyl-2-({(2S,3S,5S)-5-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxy-1,6-diphenylhexan-2-yl}amino)-2-oxoethyl]carbamate'>OO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OO4:methyl+[(1S)-1-cyclopropyl-2-({(2S,3S,5S)-5-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxy-1,6-diphenylhexan-2-yl}amino)-2-oxoethyl]carbamate'>OO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pji OCA], [~~http~~://pdbe.org/6pji PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pji RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pji PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pji ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pji OCA], [https://pdbe.org/6pji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pji RCSB], [https://www.ebi.ac.uk/pdbsum/6pji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pji ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:25, 26 August 2020

OCA — Wed, 26 Aug 2020 11:25:19 GMT

←Older revision		Revision as of 11:25, 26 August 2020
Line 1:		Line 1:

	==HIV-1 Protease NL4-3 WT in Complex with LR3-43==		==HIV-1 Protease NL4-3 WT in Complex with LR3-43==
-	<StructureSection load='6pji' size='340' side='right'caption='[[6pji]]' scene=''>	+	<StructureSection load='6pji' size='340' side='right'caption='[[6pji]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PJI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PJI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pji]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PJI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PJI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pji OCA], [http://pdbe.org/6pji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pji RCSB], [http://www.ebi.ac.uk/pdbsum/6pji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pji ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OO4:methyl+[(1S)-1-cyclopropyl-2-({(2S,3S,5S)-5-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxy-1,6-diphenylhexan-2-yl}amino)-2-oxoethyl]carbamate'>OO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pji OCA], [http://pdbe.org/6pji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pji RCSB], [http://www.ebi.ac.uk/pdbsum/6pji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pji ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The design, synthesis, and X-ray structural analysis of hybrid HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran (bis-THF) in a pseudo-C2-symmetric dipeptide isostere are described. A series of PIs were synthesized by incorporating bis-THF of darunavir on either side of the Phe-Phe isostere of lopinavir in combination with hydrophobic amino acids on the opposite P2/P2' position. Structure-activity relationship studies indicated that the bis-THF moiety can be attached at either the P2 or P2' position without significantly affecting potency. However, the group on the opposite P2/P2' position had a dramatic effect on potency depending on the size and shape of the side chain. Cocrystal structures of inhibitors with wild-type HIV-1 protease revealed that the bis-THF moiety retained similar interactions as observed in the darunavir-protease complex regardless of position on the Phe-Phe isostere. Analyses of cocrystal structures and molecular dynamics simulations provide insights for optimizing HIV-1 PIs containing bis-THF in non-sulfonamide dipeptide isosteres.
		+
		+	Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-Tetrahydrofuran in a Pseudo-Symmetric Dipeptide Isostere.,Rusere LN, Lockbaum GJ, Henes M, Lee SK, Spielvogel E, Rao DN, Kosovrasti K, Nalivaika EA, Swanstrom R, Kurt Yilmaz N, Schiffer CA, Ali A J Med Chem. 2020 Jul 16. doi: 10.1021/acs.jmedchem.0c00529. PMID:32672965<ref>PMID:32672965</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6pji" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ali A]]	+	[[Category: Ali, A]]
-	[[Category: Henes M]]	+	[[Category: Henes, M]]
-	[[Category: Kosovrasti K]]	+	[[Category: Kosovrasti, K]]
-	[[Category: KurtYilmaz N]]	+	[[Category: KurtYilmaz, N]]
-	[[Category: Lee SK]]	+	[[Category: Lee, S K]]
-	[[Category: Lockbaum GJ]]	+	[[Category: Lockbaum, G J]]
-	[[Category: Nalivaika EA]]	+	[[Category: Nalivaika, E A]]
-	[[Category: Rusere LN]]	+	[[Category: Rusere, L N]]
-	[[Category: Schiffer CA]]	+	[[Category: Schiffer, C A]]
-	[[Category: Spielvogel E]]	+	[[Category: Spielvogel, E]]
-	[[Category: Swanstrom R]]	+	[[Category: Swanstrom, R]]
		+	[[Category: Drug resistance]]
		+	[[Category: Hiv]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase inhibitor complex]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Nl4-3 protease]]
		+	[[Category: Protease inhibitor]]

OCA at 11:31, 29 July 2020

OCA — Wed, 29 Jul 2020 11:31:57 GMT

←Older revision		Revision as of 11:31, 29 July 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6pji ~~is ON HOLD until Paper Publication~~	+	==HIV-1 Protease NL4-3 WT in Complex with LR3-43==
-		+	<StructureSection load='6pji' size='340' side='right'caption='[[6pji]]' scene=''>
-	~~Authors~~: ~~Lockbaum, G~~.J.~~, Rusere, L~~.N.~~, Henes, M~~.~~, Kosovrasti, K~~.~~, Lee, S~~.K.~~, Spielvogel, E~~., ~~Nalivaika, E~~.A., ~~Swanstrom, R~~., ~~KurtYilmaz, N~~., ~~Schiffer, C~~.A., ~~Ali, A~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PJI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PJI FirstGlance]. <br>
-	~~Description: HIV-1 Protease NL4-3 WT in Complex with LR3-43~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pji OCA], [http://pdbe.org/6pji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pji RCSB], [http://www.ebi.ac.uk/pdbsum/6pji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pji ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Lee, S.K~~]]	+	__TOC__
-	[[Category: ~~Kurtyilmaz, N~~]]	+	</StructureSection>
-	[[Category: ~~Henes, M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Rusere, L.~~N]]	+	[[Category: Ali A]]
-	[[Category: ~~Lockbaum, G.J~~]]	+	[[Category: Henes M]]
-	[[Category: ~~Schiffer, C.A~~]]	+	[[Category: Kosovrasti K]]
-	[[Category: ~~Kosovrasti, K~~]]	+	[[Category: KurtYilmaz N]]
-	[[Category: ~~Nalivaika, E.A~~]]	+	[[Category: Lee SK]]
-	[[Category: ~~Swanstrom, R~~]]	+	[[Category: Lockbaum GJ]]
-	[[Category: ~~Ali, A~~]]	+	[[Category: Nalivaika EA]]
-	[[Category: ~~Spielvogel, E~~]]	+	[[Category: Rusere LN]]
		+	[[Category: Schiffer CA]]
		+	[[Category: Spielvogel E]]
		+	[[Category: Swanstrom R]]

OCA at 04:25, 24 July 2019

OCA — Wed, 24 Jul 2019 04:25:39 GMT

←Older revision		Revision as of 04:25, 24 July 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pji is ON HOLD	+	The entry 6pji is ON HOLD until Paper Publication

	Authors: Lockbaum, G.J., Rusere, L.N., Henes, M., Kosovrasti, K., Lee, S.K., Spielvogel, E., Nalivaika, E.A., Swanstrom, R., KurtYilmaz, N., Schiffer, C.A., Ali, A.		Authors: Lockbaum, G.J., Rusere, L.N., Henes, M., Kosovrasti, K., Lee, S.K., Spielvogel, E., Nalivaika, E.A., Swanstrom, R., KurtYilmaz, N., Schiffer, C.A., Ali, A.

OCA: Protected "6pji" [edit=sysop:move=sysop]

OCA — Wed, 10 Jul 2019 04:08:50 GMT

Protected "6pji" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:08, 10 July 2019

OCA: New page: '''Unreleased structure''' The entry 6pji is ON HOLD Authors: Lockbaum, G.J., Rusere, L.N., Henes, M., Kosovrasti, K., Lee, S.K., Spielvogel, E., Nalivaika, E.A., Swanstrom, R., KurtYil...

OCA — Wed, 10 Jul 2019 04:08:49 GMT

New page: '''Unreleased structure''' The entry 6pji is ON HOLD Authors: Lockbaum, G.J., Rusere, L.N., Henes, M., Kosovrasti, K., Lee, S.K., Spielvogel, E., Nalivaika, E.A., Swanstrom, R., KurtYil...

New page

'''Unreleased structure'''

The entry 6pji is ON HOLD

Authors: Lockbaum, G.J., Rusere, L.N., Henes, M., Kosovrasti, K., Lee, S.K., Spielvogel, E., Nalivaika, E.A., Swanstrom, R., KurtYilmaz, N., Schiffer, C.A., Ali, A.

Description: HIV-1 Protease NL4-3 WT in Complex with LR3-43
[[Category: Unreleased Structures]]
[[Category: Lee, S.K]]
[[Category: Kurtyilmaz, N]]
[[Category: Henes, M]]
[[Category: Rusere, L.N]]
[[Category: Lockbaum, G.J]]
[[Category: Schiffer, C.A]]
[[Category: Kosovrasti, K]]
[[Category: Nalivaika, E.A]]
[[Category: Swanstrom, R]]
[[Category: Ali, A]]
[[Category: Spielvogel, E]]