6plz - Revision history

OCA at 10:38, 15 November 2023

OCA — Wed, 15 Nov 2023 10:38:27 GMT

←Older revision		Revision as of 10:38, 15 November 2023
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	<StructureSection load='6plz' size='340' side='right'caption='[[6plz]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6plz' size='340' side='right'caption='[[6plz]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6plz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6plz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PLZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glra1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6plz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6plz OCA], [https://pdbe.org/6plz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6plz RCSB], [https://www.ebi.ac.uk/pdbsum/6plz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6plz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6plz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6plz OCA], [https://pdbe.org/6plz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6plz RCSB], [https://www.ebi.ac.uk/pdbsum/6plz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6plz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GLRA1_DANRE GLRA1_DANRE]] Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:10188956, PubMed:26344198). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity).[UniProtKB:P23415]<ref>PMID:10188956</ref> <ref>PMID:26344198</ref>	+	[https://www.uniprot.org/uniprot/GLRA1_DANRE GLRA1_DANRE] Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:10188956, PubMed:26344198). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity).[UniProtKB:P23415]<ref>PMID:10188956</ref> <ref>PMID:26344198</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gouaux, E]]	+	[[Category: Gouaux E]]
-	[[Category: Yu, J]]	+	[[Category: Yu J]]
-	[[Category: Zhu, H]]	+	[[Category: Zhu H]]
-	~~[[Category: Glycine receptor]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Sma~~]]	+

OCA at 09:05, 21 July 2021

OCA — Wed, 21 Jul 2021 09:05:03 GMT

←Older revision		Revision as of 09:05, 21 July 2021
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	==CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, closed state==		==CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, closed state==
-	<StructureSection load='6plz' size='340' side='right'caption='[[6plz]]' scene=''>	+	<StructureSection load='6plz' size='340' side='right'caption='[[6plz]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6PLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6plz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PLZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6plz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6plz OCA], [~~http~~://pdbe.org/6plz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6plz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6plz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6plz ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glra1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6plz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6plz OCA], [https://pdbe.org/6plz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6plz RCSB], [https://www.ebi.ac.uk/pdbsum/6plz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6plz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/GLRA1_DANRE GLRA1_DANRE]] Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:10188956, PubMed:26344198). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity).[UniProtKB:P23415]<ref>PMID:10188956</ref> <ref>PMID:26344198</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ligand-gated ion channels mediate signal transduction at chemical synapses and transition between resting, open, and desensitized states in response to neurotransmitter binding. Neurotransmitters that produce maximum open channel probabilities (Po) are full agonists, whereas those that yield lower than maximum Po are partial agonists. Cys-loop receptors are an important class of neurotransmitter receptors, yet a structure-based understanding of the mechanism of partial agonist action has proven elusive. Here, we study the glycine receptor with the full agonist glycine and the partial agonists taurine and gamma-amino butyric acid (GABA). We use electrophysiology to show how partial agonists populate agonist-bound, closed channel states and cryo-EM reconstructions to illuminate the structures of intermediate, pre-open states, providing insights into previously unseen conformational states along the receptor reaction pathway. We further correlate agonist-induced conformational changes to Po across members of the receptor family, providing a hypothetical mechanism for partial and full agonist action at Cys-loop receptors.
		+
		+	Mechanism of gating and partial agonist action in the glycine receptor.,Yu J, Zhu H, Lape R, Greiner T, Du J, Lu W, Sivilotti L, Gouaux E Cell. 2021 Feb 18;184(4):957-968.e21. doi: 10.1016/j.cell.2021.01.026. Epub 2021 , Feb 9. PMID:33567265<ref>PMID:33567265</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6plz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gouaux E]]	+	[[Category: Gouaux, E]]
-	[[Category: Yu J]]	+	[[Category: Yu, J]]
-	[[Category: Zhu H]]	+	[[Category: Zhu, H]]
		+	[[Category: Glycine receptor]]
		+	[[Category: Membrane protein]]
		+	[[Category: Sma]]

OCA at 08:53, 6 January 2021

OCA — Wed, 06 Jan 2021 08:53:16 GMT

←Older revision		Revision as of 08:53, 6 January 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6plz is ~~ON HOLD until Paper Publication~~	+	==CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, closed state==
-		+	<StructureSection load='6plz' size='340' side='right'caption='[[6plz]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PLZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6plz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6plz OCA], [http://pdbe.org/6plz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6plz RCSB], [http://www.ebi.ac.uk/pdbsum/6plz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6plz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gouaux E]]
		+	[[Category: Yu J]]
		+	[[Category: Zhu H]]

OCA at 07:12, 2 October 2019

OCA — Wed, 02 Oct 2019 07:12:24 GMT

←Older revision		Revision as of 07:12, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6plz is ON HOLD	+	The entry 6plz is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6plz" [edit=sysop:move=sysop]

OCA — Wed, 10 Jul 2019 04:14:54 GMT

Protected "6plz" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:14, 10 July 2019

OCA: New page: '''Unreleased structure''' The entry 6plz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Jul 2019 04:14:53 GMT

New page: '''Unreleased structure''' The entry 6plz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6plz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]