6pny - Revision history

OCA at 07:32, 11 October 2023

OCA — Wed, 11 Oct 2023 07:32:37 GMT

←Older revision		Revision as of 07:32, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6pny' size='340' side='right'caption='[[6pny]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6pny' size='340' side='right'caption='[[6pny]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pny]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fratt Fratt~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PNY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6PNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pny]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis_SCHU_S4 Francisella tularensis subsp. tularensis SCHU S4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PNY FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[2mu4\|2mu4]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">BZ14_1359 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=177416 FRATT])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pny OCA], [https://pdbe.org/6pny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pny RCSB], [https://www.ebi.ac.uk/pdbsum/6pny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pny ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6pny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pny OCA], [~~http~~://pdbe.org/6pny PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pny RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pny PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pny ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5NF33_FRATT Q5NF33_FRATT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Fratt~~]]	+	[[Category: Francisella tularensis subsp. tularensis SCHU S4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barty, A]]	+	[[Category: Barty A]]
-	[[Category: Basu, S]]	+	[[Category: Basu S]]
-	[[Category: Batyuk, A]]	+	[[Category: Batyuk A]]
-	[[Category: Cherezov, V]]	+	[[Category: Cherezov V]]
-	[[Category: Coe, J]]	+	[[Category: Coe J]]
-	[[Category: Conrad, C]]	+	[[Category: Conrad C]]
-	[[Category: Craciunescu, F]]	+	[[Category: Craciunescu F]]
-	[[Category: Fromme, P]]	+	[[Category: Fromme P]]
-	[[Category: Galli, L]]	+	[[Category: Galli L]]
-	[[Category: Gati, C]]	+	[[Category: Gati C]]
-	[[Category: Grant~~, T D~~]]	+	[[Category: Grant TD]]
-	[[Category: Gupta, C]]	+	[[Category: Gupta C]]
-	[[Category: Hansen~~, D T~~]]	+	[[Category: Hansen DT]]
-	[[Category: Hunter, M]]	+	[[Category: Hunter M]]
-	[[Category: Ishchenko, A]]	+	[[Category: Ishchenko A]]
-	[[Category: James, D]]	+	[[Category: James D]]
-	[[Category: Li, C]]	+	[[Category: Li C]]
-	[[Category: Liang, M]]	+	[[Category: Liang M]]
-	[[Category: Liu, W]]	+	[[Category: Liu W]]
-	[[Category: Nelson, G]]	+	[[Category: Nelson G]]
-	[[Category: Shekhar, M]]	+	[[Category: Shekhar M]]
-	[[Category: Singharoy, A]]	+	[[Category: Singharoy A]]
-	[[Category: Stauch, B]]	+	[[Category: Stauch B]]
-	[[Category: Thifault, D]]	+	[[Category: Thifault D]]
-	[[Category: Weierstall, U]]	+	[[Category: Weierstall U]]
-	[[Category: White, T]]	+	[[Category: White T]]
-	[[Category: Zatsepin~~, N A~~]]	+	[[Category: Zatsepin NA]]
-	[[Category: Zhao, Y]]	+	[[Category: Zhao Y]]
-	[[Category: Zook~~, J D]]~~	+	[[Category: Zook JD]]
-	~~[[Category: Allergen]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Virulence determinant~~]]	+

OCA at 06:02, 20 May 2020

OCA — Wed, 20 May 2020 06:02:53 GMT

←Older revision		Revision as of 06:02, 20 May 2020
Line 3:		Line 3:
	<StructureSection load='6pny' size='340' side='right'caption='[[6pny]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6pny' size='340' side='right'caption='[[6pny]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pny]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fratt Fratt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PNY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pny]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fratt Fratt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PNY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PNY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu4\|2mu4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu4\|2mu4]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BZ14_1359 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=177416 FRATT])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BZ14_1359 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=177416 FRATT])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pny OCA], [http://pdbe.org/6pny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pny RCSB], [http://www.ebi.ac.uk/pdbsum/6pny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pny ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pny OCA], [http://pdbe.org/6pny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pny RCSB], [http://www.ebi.ac.uk/pdbsum/6pny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pny ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:22, 18 March 2020

OCA — Wed, 18 Mar 2020 10:22:03 GMT

←Older revision		Revision as of 10:22, 18 March 2020
Line 3:		Line 3:
	<StructureSection load='6pny' size='340' side='right'caption='[[6pny]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6pny' size='340' side='right'caption='[[6pny]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pny]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pny]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fratt Fratt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PNY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu4\|2mu4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu4\|2mu4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BZ14_1359 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=177416 FRATT])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pny OCA], [http://pdbe.org/6pny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pny RCSB], [http://www.ebi.ac.uk/pdbsum/6pny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pny ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pny OCA], [http://pdbe.org/6pny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pny RCSB], [http://www.ebi.ac.uk/pdbsum/6pny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pny ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Francisella tularensis is the causative agent for the potentially fatal disease tularemia. The lipoprotein Flpp3 has been identified as a virulence determinant of tularemia with no sequence homology outside the Francisella genus. We report a room temperature structure of Flpp3 determined by serial femtosecond crystallography that exists in a significantly different conformation than previously described by the NMR-determined structure. Furthermore, we investigated the conformational space and energy barriers between these two structures by molecular dynamics umbrella sampling and identified three low-energy intermediate states, transitions between which readily occur at room temperature. We have also begun to investigate organic compounds in silico that may act as inhibitors to Flpp3. This work paves the road to developing targeted therapeutics against tularemia and aides in our understanding of the disease mechanisms of tularemia.
		+
		+	XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia.,Zook J, Shekhar M, Hansen D, Conrad C, Grant T, Gupta C, White T, Barty A, Basu S, Zhao Y, Zatsepin N, Ishchenko A, Batyuk A, Gati C, Li C, Galli L, Coe J, Hunter M, Liang M, Weierstall U, Nelson G, James D, Stauch B, Craciunescu F, Thifault D, Liu W, Cherezov V, Singharoy A, Fromme P Structure. 2020 Feb 28. pii: S0969-2126(20)30046-0. doi:, 10.1016/j.str.2020.02.005. PMID:32142641<ref>PMID:32142641</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6pny" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Fratt]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Barty, A]]		[[Category: Barty, A]]

OCA at 09:19, 26 February 2020

OCA — Wed, 26 Feb 2020 09:19:47 GMT

←Older revision		Revision as of 09:19, 26 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6pny ~~is ON HOLD~~	+	==X-ray Structure of Flpp3==
-		+	<StructureSection load='6pny' size='340' side='right'caption='[[6pny]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6pny]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PNY FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu4\|2mu4]]</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pny OCA], [http://pdbe.org/6pny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pny RCSB], [http://www.ebi.ac.uk/pdbsum/6pny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pny ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Barty, A]]
		+	[[Category: Basu, S]]
		+	[[Category: Batyuk, A]]
		+	[[Category: Cherezov, V]]
		+	[[Category: Coe, J]]
		+	[[Category: Conrad, C]]
		+	[[Category: Craciunescu, F]]
		+	[[Category: Fromme, P]]
		+	[[Category: Galli, L]]
		+	[[Category: Gati, C]]
		+	[[Category: Grant, T D]]
		+	[[Category: Gupta, C]]
		+	[[Category: Hansen, D T]]
		+	[[Category: Hunter, M]]
		+	[[Category: Ishchenko, A]]
		+	[[Category: James, D]]
		+	[[Category: Li, C]]
		+	[[Category: Liang, M]]
		+	[[Category: Liu, W]]
		+	[[Category: Nelson, G]]
		+	[[Category: Shekhar, M]]
		+	[[Category: Singharoy, A]]
		+	[[Category: Stauch, B]]
		+	[[Category: Thifault, D]]
		+	[[Category: Weierstall, U]]
		+	[[Category: White, T]]
		+	[[Category: Zatsepin, N A]]
		+	[[Category: Zhao, Y]]
		+	[[Category: Zook, J D]]
		+	[[Category: Allergen]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Virulence determinant]]

OCA: Protected "6pny" [edit=sysop:move=sysop]

OCA — Wed, 10 Jul 2019 04:19:32 GMT

Protected "6pny" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:19, 10 July 2019

OCA: New page: '''Unreleased structure''' The entry 6pny is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Jul 2019 04:19:31 GMT

New page: '''Unreleased structure''' The entry 6pny is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6pny is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]