6pq9 - Revision history

OCA at 07:33, 11 October 2023

OCA — Wed, 11 Oct 2023 07:33:43 GMT

←Older revision		Revision as of 07:33, 11 October 2023
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	<StructureSection load='6pq9' size='340' side='right'caption='[[6pq9]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='6pq9' size='340' side='right'caption='[[6pq9]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pq9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PQ9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PQ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pq9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PQ9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.191Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tla-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pq9 OCA], [https://pdbe.org/6pq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pq9 RCSB], [https://www.ebi.ac.uk/pdbsum/6pq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pq9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pq9 OCA], [~~http~~://pdbe.org/6pq9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pq9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pq9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pq9 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9X6W1_ECOLX Q9X6W1_ECOLX]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6pq9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6pq9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Beta-lactamase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cifuentes-Castro~~, V H~~]]	+	[[Category: Cifuentes-Castro VH]]
-	[[Category: Rodriguez-Alamazan, C]]	+	[[Category: Rodriguez-Alamazan C]]
-	[[Category: Rudino-Pinera, E]]	+	[[Category: Rudino-Pinera E]]
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Hidrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lactamase]]~~	+
-	~~[[Category: Resistance~~]]	+

OCA at 16:45, 22 January 2020

OCA — Wed, 22 Jan 2020 16:45:36 GMT

←Older revision		Revision as of 16:45, 22 January 2020
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	<StructureSection load='6pq9' size='340' side='right'caption='[[6pq9]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='6pq9' size='340' side='right'caption='[[6pq9]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pq9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PQ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pq9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PQ9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tla-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pq9 OCA], [http://pdbe.org/6pq9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pq9 RCSB], [http://www.ebi.ac.uk/pdbsum/6pq9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pq9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pq9 OCA], [http://pdbe.org/6pq9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pq9 RCSB], [http://www.ebi.ac.uk/pdbsum/6pq9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pq9 ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 15:12, 11 December 2019

OCA — Wed, 11 Dec 2019 15:12:44 GMT

←Older revision		Revision as of 15:12, 11 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6pq9 is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of TLA-1 S70G extended spectrum Beta-lactamase==
		+	<StructureSection load='6pq9' size='340' side='right'caption='[[6pq9]], [[Resolution\|resolution]] 2.19Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6pq9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PQ9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pq9 OCA], [http://pdbe.org/6pq9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pq9 RCSB], [http://www.ebi.ac.uk/pdbsum/6pq9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pq9 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	beta-lactamases are the main molecules responsible for giving bacterial resistance against beta-lactam antibiotics. The study of beta-lactamases has allowed the development of antibiotics capable of inhibiting these enzymes. In this context, extended spectrum beta-lactamase (ESBL) TLA-1 has spread in Escherichia coli and Enterobacter cloacae clinical isolates during the last 30 years in Mexico. In this research, the 3D structures of ESBL TLA-1 and TLA-1 S70G mutant, both ligand-free and in complex with clavulanic acid were determined by X-ray crystallography. Four clavulanic acid molecules were found in the structure of TLA-1, two of those were intermediaries of the acylation process and were localized covalently bound to two different amino acid residues, Ser70 and Ser237. The coordinates of TLA-1 in complex with clavulanic acid shows the existence of a second acylation site, additional to Ser70, which might be extendable to several members of the subclass A beta-lactamases family. This is the first time that two serines involved in binding clavulanic acid has been reported and described to an atomic level.

-	~~Authors: Rudino~~-~~Pinera, E~~., Cifuentes-Castro, V~~.H.~~, Rodriguez-~~Alamazan,~~ C.	+	The crystal structure of ESBL TLA-1 in complex with clavulanic acid reveals a second acylation site.,Cifuentes-Castro V, Rodriguez-Almazan C, Silva-Sanchez J, Rudino-Pinera E Biochem Biophys Res Commun. 2019 Nov 25. pii: S0006-291X(19)32266-1. doi:, 10.1016/j.bbrc.2019.11.138. PMID:31780261<ref>PMID:31780261</ref>

-	~~Description: Crystal Structure~~ of ~~TLA~~-~~1 S70G extended spectrum Beta~~-~~lactamase~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Cifuentes-Castro, V.H~~]]	+	<div class="pdbe-citations 6pq9" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Rudino~~-~~Pinera~~, E]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
		+	[[Category: Cifuentes-Castro, V H]]
	[[Category: Rodriguez-Alamazan, C]]		[[Category: Rodriguez-Alamazan, C]]
		+	[[Category: Rudino-Pinera, E]]
		+	[[Category: Antibiotic]]
		+	[[Category: Hidrolase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lactamase]]
		+	[[Category: Resistance]]

OCA at 04:42, 31 July 2019

OCA — Wed, 31 Jul 2019 04:42:40 GMT

←Older revision		Revision as of 04:42, 31 July 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pq9 is ON HOLD	+	The entry 6pq9 is ON HOLD until Paper Publication

	Authors: Rudino-Pinera, E., Cifuentes-Castro, V.H., Rodriguez-Alamazan, C.		Authors: Rudino-Pinera, E., Cifuentes-Castro, V.H., Rodriguez-Alamazan, C.

OCA: Protected "6pq9" [edit=sysop:move=sysop]

OCA — Wed, 17 Jul 2019 09:06:35 GMT

Protected "6pq9" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:06, 17 July 2019

OCA: New page: '''Unreleased structure''' The entry 6pq9 is ON HOLD Authors: Rudino-Pinera, E., Cifuentes-Castro, V.H., Rodriguez-Alamazan, C. Description: Crystal Structure of TLA-1 S70G extended sp...

OCA — Wed, 17 Jul 2019 09:06:32 GMT

New page: '''Unreleased structure''' The entry 6pq9 is ON HOLD Authors: Rudino-Pinera, E., Cifuentes-Castro, V.H., Rodriguez-Alamazan, C. Description: Crystal Structure of TLA-1 S70G extended sp...

New page

'''Unreleased structure'''

The entry 6pq9 is ON HOLD

Authors: Rudino-Pinera, E., Cifuentes-Castro, V.H., Rodriguez-Alamazan, C.

Description: Crystal Structure of TLA-1 S70G extended spectrum Beta-lactamase
[[Category: Unreleased Structures]]
[[Category: Cifuentes-Castro, V.H]]
[[Category: Rudino-Pinera, E]]
[[Category: Rodriguez-Alamazan, C]]