6psl - Revision history

OCA at 10:38, 15 November 2023

OCA — Wed, 15 Nov 2023 10:38:47 GMT

←Older revision		Revision as of 10:38, 15 November 2023
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	<StructureSection load='6psl' size='340' side='right'caption='[[6psl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6psl' size='340' side='right'caption='[[6psl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6psl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PSL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6psl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PSL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=28J:D-ALLOISOLEUCINE'>28J</scene>, <scene name='pdbligand=HJV:'>HJV</scene>, <scene name='pdbligand=Q3S:'>Q3S</scene>, <scene name='pdbligand=ZAE:N-METHYL-D-PHENYLALANINE'>ZAE</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=28J:D-ALLOISOLEUCINE'>28J</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HJV:N~2~-methyl-D-glutamine'>HJV</scene>, <scene name='pdbligand=Q3S:(2R,3S)-2,3-diaminobutanoic+acid'>Q3S</scene>, <scene name='pdbligand=ZAE:N-METHYL-D-PHENYLALANINE'>ZAE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6psl OCA], [https://pdbe.org/6psl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6psl RCSB], [https://www.ebi.ac.uk/pdbsum/6psl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6psl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6psl OCA], [https://pdbe.org/6psl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6psl RCSB], [https://www.ebi.ac.uk/pdbsum/6psl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6psl ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, X]]	+	[[Category: Synthetic construct]]
-	[[Category: Nowick~~, J S~~]]	+	[[Category: Li X]]
-	[[Category: Pishenko, A]]	+	[[Category: Nowick JS]]
-	[[Category: Yang, H]]	+	[[Category: Pishenko A]]
-	~~[[Category: Antibiotic]]~~	+	[[Category: Yang H]]
-	~~[[Category: Azateixobactin]]~~	+
-	~~[[Category: Teixobactin~~]]	+

OCA at 09:32, 15 September 2021

OCA — Wed, 15 Sep 2021 09:32:58 GMT

←Older revision		Revision as of 09:32, 15 September 2021
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	<StructureSection load='6psl' size='340' side='right'caption='[[6psl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6psl' size='340' side='right'caption='[[6psl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6psl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PSL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PSL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6psl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PSL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=28J:D-ALLOISOLEUCINE'>28J</scene>, <scene name='pdbligand=HJV:'>HJV</scene>, <scene name='pdbligand=Q3S:'>Q3S</scene>, <scene name='pdbligand=ZAE:N-METHYL-D-PHENYLALANINE'>ZAE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=28J:D-ALLOISOLEUCINE'>28J</scene>, <scene name='pdbligand=HJV:'>HJV</scene>, <scene name='pdbligand=Q3S:'>Q3S</scene>, <scene name='pdbligand=ZAE:N-METHYL-D-PHENYLALANINE'>ZAE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6psl OCA], [~~http~~://pdbe.org/6psl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6psl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6psl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6psl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6psl OCA], [https://pdbe.org/6psl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6psl RCSB], [https://www.ebi.ac.uk/pdbsum/6psl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6psl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:53, 27 November 2019

OCA — Wed, 27 Nov 2019 06:53:29 GMT

←Older revision		Revision as of 06:53, 27 November 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6psl is ~~ON HOLD until Jul 12 2021~~	+	==Structure of a N-Me-D-Gln4,D-aza-Thr8,Arg10-teixobactin analogue==
		+	<StructureSection load='6psl' size='340' side='right'caption='[[6psl]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6psl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PSL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=28J:D-ALLOISOLEUCINE'>28J</scene>, <scene name='pdbligand=HJV:'>HJV</scene>, <scene name='pdbligand=Q3S:'>Q3S</scene>, <scene name='pdbligand=ZAE:N-METHYL-D-PHENYLALANINE'>ZAE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6psl OCA], [http://pdbe.org/6psl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6psl RCSB], [http://www.ebi.ac.uk/pdbsum/6psl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6psl ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	This paper describes the chemical synthesis, X-ray crystallographic structure, and antibiotic activity assay of lactam analogues of teixobactin and explores ring-expanded analogues of teixobactin with beta3-homo amino acids. Lactam analogues of teixobactin containing all four stereoisomers of azathreonine at position 8 were synthesized on a solid support from commercially available stereoisomeric threonine derivatives. The threonine stereoisomers are converted to the diastereomeric aza-threonines by mesylation, azide displacement, and reduction during the synthesis. D-aza-Thr8,Arg10-teixobactin exhibits 2-8-fold greater antibiotic activity than the corresponding macrolactone Arg10-teixobactin. Aza-teixobactin analogues containing other stereoisomers of aza-threonine are inactive. A dramatic 16-128-fold increase in the activity of teixobactin and teixobactin analogues is observed with the inclusion of 0.002% of the mild detergent polysorbate 80 in the MIC assay. The X-ray crystallographic structure of N-Me-D-Gln4,D-aza-Thr8,Arg10-teixobactin reveals an amphipathic hydrogen-bonded antiparallel beta-sheet dimer that binds chloride anions. In the binding site, the macrolactam amide NH groups of residues 8, 10, and 11, as well as the extra amide NH group of the lactam ring, hydrogen bond to the chloride anion. The teixobactin pharmacophore tolerates ring expansion of the 13-membered ring to 14-,15-, and 16-membered rings containing beta3-homo amino acids with retention of partial or full antibiotic activity.

-	~~Authors~~:	+	Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin.,Yang H, Pishenko AV, Li X, Nowick JS J Org Chem. 2019 Nov 20. doi: 10.1021/acs.joc.9b02631. PMID:31746604<ref>PMID:31746604</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6psl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Li, X]]
		+	[[Category: Nowick, J S]]
		+	[[Category: Pishenko, A]]
		+	[[Category: Yang, H]]
		+	[[Category: Antibiotic]]
		+	[[Category: Azateixobactin]]
		+	[[Category: Teixobactin]]

OCA at 07:13, 2 October 2019

OCA — Wed, 02 Oct 2019 07:13:16 GMT

←Older revision		Revision as of 07:13, 2 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6psl is ON HOLD	+	The entry 6psl is ON HOLD until Jul 12 2021

	Authors:		Authors:

OCA: Protected "6psl" [edit=sysop:move=sysop]

OCA — Wed, 24 Jul 2019 04:30:32 GMT

Protected "6psl" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:30, 24 July 2019

OCA: New page: '''Unreleased structure''' The entry 6psl is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 Jul 2019 04:30:31 GMT

New page: '''Unreleased structure''' The entry 6psl is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6psl is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]