6pti - Revision history

OCA at 03:40, 9 February 2016

OCA — Tue, 09 Feb 2016 03:40:22 GMT

←Older revision		Revision as of 03:40, 9 February 2016
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	<StructureSection load='6pti' size='340' side='right' caption='[[6pti]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6pti' size='340' side='right' caption='[[6pti]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pti]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PTI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pti]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PTI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pti OCA], [http://www.rcsb.org/pdb/explore.do?structureId=6pti RCSB], [http://www.ebi.ac.uk/pdbsum/6pti PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pti OCA], [http://pdbe.org/6pti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pti RCSB], [http://www.ebi.ac.uk/pdbsum/6pti PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=6pti ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 6pti" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Wlodawer, A]]		[[Category: Wlodawer, A]]

OCA at 04:09, 25 December 2014

OCA — Thu, 25 Dec 2014 04:09:26 GMT

←Older revision		Revision as of 04:09, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pti OCA], [http://www.rcsb.org/pdb/explore.do?structureId=6pti RCSB], [http://www.ebi.ac.uk/pdbsum/6pti PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pti OCA], [http://www.rcsb.org/pdb/explore.do?structureId=6pti RCSB], [http://www.ebi.ac.uk/pdbsum/6pti PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:04, 10 December 2014

OCA — Wed, 10 Dec 2014 17:04:47 GMT

←Older revision		Revision as of 17:04, 10 December 2014
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-	[[~~Image~~:6pti.~~png\|left~~\|200px]]	+	==STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR==
		+	<StructureSection load='6pti' size='340' side='right' caption='[[6pti]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6pti]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PTI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pti OCA], [http://www.rcsb.org/pdb/explore.do?structureId=6pti RCSB], [http://www.ebi.ac.uk/pdbsum/6pti PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pt/6pti_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of bovine pancreatic trypsin inhibitor has been solved in a new crystal form III. The crystals belong to space group P2(1)2(1)2 with a = 55.2 A, b = 38.2 A, c = 24.05 A. The structure was solved on the basis of co-ordinates of forms I and II of the inhibitor by molecular replacement, and the X-ray data extending to 1.7 A were used in a restrained least-squares refinement. The final R factor was 0.16, and the deviation of bonded distances from ideality was 0.020 A. Root-mean-square discrepancy between C alpha co-ordinates of forms III and I are 0.47 A, whilst between forms II and III the discrepancy is 0.39 A. These deviations are about a factor of 3 larger than the expected experimental errors, showing that true differences exist between the three crystal forms. Two residues (Arg39 and Asp50) were modeled with two positions for their side-chains. The final model includes 73 water molecules and one phosphate group bound to the protein. Sixteen water molecules occupy approximately the same positions in all three crystal forms studied to date, indicating their close association with the protein molecule. Temperature factors also show a high degree of correlation between the three crystal forms.

-	~~{{STRUCTURE_6pti\| PDB=6pti \| SCENE= }}~~	+	Structure of form III crystals of bovine pancreatic trypsin inhibitor.,Wlodawer A, Nachman J, Gilliland GL, Gallagher W, Woodward C J Mol Biol. 1987 Dec 5;198(3):469-80. PMID:2448484<ref>PMID:2448484</ref>

-	~~===STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_2448484}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[6pti]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=6PTI OCA].~~	+

	==See Also==		==See Also==
	*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]		*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:002448484<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Wlodawer, A.]]	+	[[Category: Wlodawer, A]]

OCA at 12:31, 20 October 2012

OCA — Sat, 20 Oct 2012 12:31:00 GMT

←Older revision		Revision as of 12:31, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[6pti]] is a 1 chain structure ~~of [[Basic Pancreatic Trypsin Inhibitor]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTI OCA].	+	[[6pti]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTI OCA].

	==See Also==		==See Also==

OCA at 08:58, 26 July 2012

OCA — Thu, 26 Jul 2012 08:58:25 GMT

←Older revision		Revision as of 08:58, 26 July 2012
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	[[Image:6pti.png\|left\|200px]]		[[Image:6pti.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_6pti", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_6pti\| PDB=6pti \| SCENE= }}		{{STRUCTURE_6pti\| PDB=6pti \| SCENE= }}

	===STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR===		===STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_2448484}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 2448484 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_2448484}}		{{ABSTRACT_PUBMED_2448484}}

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	==See Also==		==See Also==
-	*[[Basic Pancreatic Trypsin Inhibitor]]	+	*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~2448484~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:002448484</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Wlodawer, A.]]		[[Category: Wlodawer, A.]]

OCA: Protected "6pti" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 22:13:24 GMT

Protected "6pti" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:13, 26 December 2010

OCA at 22:13, 26 December 2010

OCA — Sun, 26 Dec 2010 22:13:23 GMT

←Older revision		Revision as of 22:13, 26 December 2010
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-	{{Seed}}
	[[Image:6pti.png\|left\|200px]]		[[Image:6pti.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~6PTI~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTI OCA].	+	[[6pti]] is a 1 chain structure of [[Basic Pancreatic Trypsin Inhibitor]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTI OCA].
		+
		+	==See Also==
		+	*[[Basic Pancreatic Trypsin Inhibitor]]

	==Reference==		==Reference==
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Wlodawer, A.]]		[[Category: Wlodawer, A.]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:10:43 2009''

OCA at 04:10, 17 February 2009

OCA — Tue, 17 Feb 2009 04:10:45 GMT

←Older revision		Revision as of 04:10, 17 February 2009
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	==About this Structure==		==About this Structure==
-	6PTI is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTI OCA].	+	6PTI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTI OCA].

	==Reference==		==Reference==
-	~~Structure of form III crystals of bovine pancreatic trypsin inhibitor., Wlodawer A, Nachman J, Gilliland GL, Gallagher W, Woodward C, J Mol Biol. 1987 Dec 5;198(3):469-80.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/2448484 2448484]~~	+	<ref group="xtra">PMID:2448484</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Single protein]]
	[[Category: Wlodawer, A.]]		[[Category: Wlodawer, A.]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3 14~~:24:~~40 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:10:43 2009''

OCA at 11:24, 3 July 2008

OCA — Thu, 03 Jul 2008 11:24:41 GMT

←Older revision		Revision as of 11:24, 3 July 2008
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-	[[Image:6pti.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:6pti.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_6pti\| PDB=6pti \| SCENE= }}		{{STRUCTURE_6pti\| PDB=6pti \| SCENE= }}

-	~~'''~~STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR~~'''~~	+	===STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR===


-	~~==Overview==~~	+	<!--
-	The ~~structure of bovine pancreatic trypsin inhibitor has been solved in a new crystal form III. The crystals belong to space group P2(1)2(1)2 with a = 55.2 A~~, ~~b = 38.2 A~~, ~~c = 24.05 A. The structure was solved on~~ the ~~basis of co-ordinates of forms I and II of the inhibitor by molecular replacement, and the X-ray data extending~~ to ~~1.7 A were used in a restrained least-squares refinement. The final R factor was 0.16, and~~ the ~~deviation of bonded distances from ideality was 0~~.~~020 A~~. ~~Root-mean-square discrepancy between C alpha co-ordinates of forms III and I are 0.47 A~~, ~~whilst between forms II and III the discrepancy~~ is ~~0.39 A. These deviations are about a factor of 3 larger than~~ the ~~expected experimental errors, showing that true differences exist between the three crystal forms~~. ~~Two residues (Arg39 and Asp50) were modeled with two positions for their side~~-chains. The final model includes 73 water molecules and one phosphate group bound to the protein. Sixteen water molecules occupy approximately the same positions in all three crystal forms studied to date, indicating their close association with the protein molecule. Temperature factors also show a high degree of correlation between the three crystal forms.	+	The line below this paragraph, {{ABSTRACT_PUBMED_2448484}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 2448484 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_2448484}}

	==About this Structure==		==About this Structure==
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	[[Category: Single protein]]		[[Category: Single protein]]
	[[Category: Wlodawer, A.]]		[[Category: Wlodawer, A.]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:42:30 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:24:40 2008''

OCA at 19:42, 4 May 2008

OCA — Sun, 04 May 2008 19:42:31 GMT

←Older revision		Revision as of 19:42, 4 May 2008
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	[[Image:6pti.gif\|left\|200px]]		[[Image:6pti.gif\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 6pti \|SIZE=350\|CAPTION= <~~scene ~~name='initialview01'>6pti</scene>~~, ~~resolution 1~~.~~7Å~~	+	The line below this paragraph, containing "STRUCTURE_6pti", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~>	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	\|~~ACTIVITY~~=	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~=	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_6pti\| PDB=6pti \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pti OCA], [http://www.ebi.ac.uk/pdbsum/6pti PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=6pti RCSB]</span>	+
-	}}	+

	'''STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR'''		'''STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR'''
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	[[Category: Single protein]]		[[Category: Single protein]]
	[[Category: Wlodawer, A.]]		[[Category: Wlodawer, A.]]
-	~~[[Category: proteinase inhibitor (trypsin)]]~~	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:42:30 2008''
-		+
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:43:29 2008''	+