6pvm - Revision history

OCA at 09:27, 20 March 2024

OCA — Wed, 20 Mar 2024 09:27:34 GMT

←Older revision		Revision as of 09:27, 20 March 2024
Line 3:		Line 3:
	<SX load='6pvm' size='340' side='right' viewer='molstar' caption='[[6pvm]], [[Resolution\|resolution]] 4.50Å' scene=''>		<SX load='6pvm' size='340' side='right' viewer='molstar' caption='[[6pvm]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6PVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PVM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Trpv3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6pvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvm OCA], [~~http~~://pdbe.org/6pvm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pvm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pvm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvm OCA], [https://pdbe.org/6pvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pvm RCSB], [https://www.ebi.ac.uk/pdbsum/6pvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).	+	[https://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo alpha-to-pi transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains.	+

-	Structural basis of temperature sensation by the TRP channel TRPV3.,Singh AK, McGoldrick LL, Demirkhanyan L, Leslie M, Zakharian E, Sobolevsky AI Nat Struct Mol Biol. 2019 Oct 21. pii: 10.1038/s41594-019-0318-7. doi:, 10.1038/s41594-019-0318-7. PMID:31636415<ref>PMID:31636415</ref>	+	==See Also==
-		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 6pvm" style="background-color:#fffaf0;"></div>~~	+
-	== ~~References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: McGoldrick~~, L L~~]]	+	[[Category: McGoldrick LL]]
-	[[Category: Singh~~, A K~~]]	+	[[Category: Singh AK]]
-	[[Category: Sobolevsky~~, A I]]~~	+	[[Category: Sobolevsky AI]]
-	~~[[Category: Ion channel]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Trp channel~~]]	+

OCA at 04:39, 11 April 2020

OCA — Sat, 11 Apr 2020 04:39:03 GMT

←Older revision		Revision as of 04:39, 11 April 2020
Line 3:		Line 3:
	<SX load='6pvm' size='340' side='right' viewer='molstar' caption='[[6pvm]], [[Resolution\|resolution]] 4.50Å' scene=''>		<SX load='6pvm' size='340' side='right' viewer='molstar' caption='[[6pvm]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PVM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Trpv3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Trpv3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvm OCA], [http://pdbe.org/6pvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pvm RCSB], [http://www.ebi.ac.uk/pdbsum/6pvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvm OCA], [http://pdbe.org/6pvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pvm RCSB], [http://www.ebi.ac.uk/pdbsum/6pvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:27, 6 March 2020

OCA — Fri, 06 Mar 2020 23:27:42 GMT

←Older revision		Revision as of 23:27, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of mouse TRPV3 in putative sensitized state at 42 degrees Celsius==		==Cryo-EM structure of mouse TRPV3 in putative sensitized state at 42 degrees Celsius==
-	<~~StructureSection~~ load='6pvm' size='340' side='right'caption='[[6pvm]], [[Resolution\|resolution]] 4.50Å' scene=''>	+	<SX load='6pvm' size='340' side='right' viewer='molstar' caption='[[6pvm]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PVM FirstGlance]. <br>		<table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PVM FirstGlance]. <br>
Line 22:		Line 22:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]

OCA at 08:34, 6 November 2019

OCA — Wed, 06 Nov 2019 08:34:02 GMT

←Older revision		Revision as of 08:34, 6 November 2019
Line 3:		Line 3:
	<StructureSection load='6pvm' size='340' side='right'caption='[[6pvm]], [[Resolution\|resolution]] 4.50Å' scene=''>		<StructureSection load='6pvm' size='340' side='right'caption='[[6pvm]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PVM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Trpv3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvm OCA], [http://pdbe.org/6pvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pvm RCSB], [http://www.ebi.ac.uk/pdbsum/6pvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvm OCA], [http://pdbe.org/6pvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pvm RCSB], [http://www.ebi.ac.uk/pdbsum/6pvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).		[[http://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo alpha-to-pi transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains.
		+
		+	Structural basis of temperature sensation by the TRP channel TRPV3.,Singh AK, McGoldrick LL, Demirkhanyan L, Leslie M, Zakharian E, Sobolevsky AI Nat Struct Mol Biol. 2019 Oct 21. pii: 10.1038/s41594-019-0318-7. doi:, 10.1038/s41594-019-0318-7. PMID:31636415<ref>PMID:31636415</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6pvm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: McGoldrick, L L]]		[[Category: McGoldrick, L L]]
	[[Category: Singh, A K]]		[[Category: Singh, A K]]

OCA at 06:59, 23 October 2019

OCA — Wed, 23 Oct 2019 06:59:26 GMT

←Older revision		Revision as of 06:59, 23 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6pvm is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of mouse TRPV3 in putative sensitized state at 42 degrees Celsius==
-		+	<StructureSection load='6pvm' size='340' side='right'caption='[[6pvm]], [[Resolution\|resolution]] 4.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PVM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvm OCA], [http://pdbe.org/6pvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pvm RCSB], [http://www.ebi.ac.uk/pdbsum/6pvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvm ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: McGoldrick, L L]]
		+	[[Category: Singh, A K]]
		+	[[Category: Sobolevsky, A I]]
		+	[[Category: Ion channel]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transport protein]]
		+	[[Category: Trp channel]]

OCA at 13:45, 28 August 2019

OCA — Wed, 28 Aug 2019 13:45:40 GMT

←Older revision		Revision as of 13:45, 28 August 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pvm is ON HOLD	+	The entry 6pvm is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6pvm" [edit=sysop:move=sysop]

OCA — Wed, 31 Jul 2019 04:46:43 GMT

Protected "6pvm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:46, 31 July 2019

OCA: New page: '''Unreleased structure''' The entry 6pvm is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 31 Jul 2019 04:46:41 GMT

New page: '''Unreleased structure''' The entry 6pvm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6pvm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]