6pya - Revision history

OCA at 12:10, 1 January 2020

OCA — Wed, 01 Jan 2020 12:10:45 GMT

←Older revision		Revision as of 12:10, 1 January 2020
Line 3:		Line 3:
	<StructureSection load='6pya' size='340' side='right'caption='[[6pya]], [[Resolution\|resolution]] 1.71Å' scene=''>		<StructureSection load='6pya' size='340' side='right'caption='[[6pya]], [[Resolution\|resolution]] 1.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pya]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PYA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pya]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PYA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=P57:3-[(1H-imidazol-1-yl)methyl]-2-phenyl-1H-indole'>P57</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=P57:3-[(1H-imidazol-1-yl)methyl]-2-phenyl-1H-indole'>P57</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SHBG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pya OCA], [http://pdbe.org/6pya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pya RCSB], [http://www.ebi.ac.uk/pdbsum/6pya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pya ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pya OCA], [http://pdbe.org/6pya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pya RCSB], [http://www.ebi.ac.uk/pdbsum/6pya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pya ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SHBG_HUMAN SHBG_HUMAN]] Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.		[[http://www.uniprot.org/uniprot/SHBG_HUMAN SHBG_HUMAN]] Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sex hormone-binding globulin (SHBG) determines the equilibrium between free and protein-bound androgens and estrogens in the blood and regulates their access to target tissues. Using crystallographic approaches and radiolabeled competitive binding-capacity assays, we report here how two non-steroidal compounds bind to human SHBG, and how they influence androgen activity in cell culture. We found that one of these compounds, (-)3,4-divanillyltetrahydrofuran (DVT), present in stinging nettle root extracts and used as a nutraceutical, binds SHBG with relatively low affinity. By contrast a, synthetic compound, 3-(1H-imidazol-1-ylmethyl)-2phenyl-1H-indole (IPI), bound SHBG with an affinity similar to that of testosterone and estradiol. Crystal structures of SHBG in complex with DVT or IPI at 1.71-1.80 A resolutions revealed their unique orientations in the SHBG ligand-binding pocket and suggested opportunities for the design of other non-steroidal ligands of SHBG. As observed for estradiol but not testosterone, IPI binding to SHBG was reduced by ~20 fold in the presence of zinc, whereas DVT binding was almost completely lost. Estradiol dependent fibulin-2 interactions with SHBG similarly occurred for IPI-bound SHBG, but not with DVT-bound SHBG. Both DVT and IPI increased the activity of testosterone in a cell culture androgen reporter system by competitively displacing testosterone from SHBG. These findings indicate how non-steroidal ligands of SHBG maybe designed to modulate the bioavailability of sex steroids.
		+
		+	Molecular interactions between sex hormone-binding globulin and non-steroidal ligands that enhance androgen action.,Round P, Das S, Wu TS, Wahala K, Van Petegem F, Hammond GL J Biol Chem. 2019 Dec 18. pii: RA119.011051. doi: 10.1074/jbc.RA119.011051. PMID:31852737<ref>PMID:31852737</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6pya" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Das, S]]		[[Category: Das, S]]

OCA at 09:12, 25 December 2019

OCA — Wed, 25 Dec 2019 09:12:51 GMT

←Older revision		Revision as of 09:12, 25 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6pya is ~~ON HOLD until Paper Publication~~	+	==Sex Hormone-binding globulin mutant E176K in complex with IPI==
-		+	<StructureSection load='6pya' size='340' side='right'caption='[[6pya]], [[Resolution\|resolution]] 1.71Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6pya]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PYA FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=P57:3-[(1H-imidazol-1-yl)methyl]-2-phenyl-1H-indole'>P57</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pya OCA], [http://pdbe.org/6pya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pya RCSB], [http://www.ebi.ac.uk/pdbsum/6pya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pya ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SHBG_HUMAN SHBG_HUMAN]] Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Das, S]]
		+	[[Category: Petegem, F Van]]
		+	[[Category: Round, P W]]
		+	[[Category: Hormone]]
		+	[[Category: Sex steroid transport binding globulin]]

OCA at 07:15, 2 October 2019

OCA — Wed, 02 Oct 2019 07:15:52 GMT

←Older revision		Revision as of 07:15, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pya is ON HOLD	+	The entry 6pya is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6pya" [edit=sysop:move=sysop]

OCA — Wed, 07 Aug 2019 04:19:57 GMT

Protected "6pya" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:19, 7 August 2019

OCA: New page: '''Unreleased structure''' The entry 6pya is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 07 Aug 2019 04:19:56 GMT

New page: '''Unreleased structure''' The entry 6pya is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6pya is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]