6pyx - Revision history

OCA at 07:38, 11 October 2023

OCA — Wed, 11 Oct 2023 07:38:28 GMT

←Older revision		Revision as of 07:38, 11 October 2023
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	<StructureSection load='6pyx' size='340' side='right'caption='[[6pyx]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6pyx' size='340' side='right'caption='[[6pyx]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pyx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PYX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pyx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PYX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6pyo\|6pyo]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pyx OCA], [~~http~~://pdbe.org/6pyx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pyx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pyx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pyx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pyx OCA], [https://pdbe.org/6pyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pyx RCSB], [https://www.ebi.ac.uk/pdbsum/6pyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pyx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CLCA1_HUMAN CLCA1_HUMAN] May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.<ref>PMID:11445004</ref> <ref>PMID:11842292</ref> <ref>PMID:11956057</ref> <ref>PMID:23112050</ref> <ref>PMID:9828122</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berry~~, K B~~]]	+	[[Category: Berry KB]]
-	[[Category: Brett~~, T J]]~~	+	[[Category: Brett TJ]]
-	~~[[Category: Chloride channel regulator]]~~	+
-	~~[[Category: Ion channel regulator]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Vwa domain~~]]	+

OCA at 04:42, 13 February 2020

OCA — Thu, 13 Feb 2020 04:42:24 GMT

←Older revision		Revision as of 04:42, 13 February 2020
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	<StructureSection load='6pyx' size='340' side='right'caption='[[6pyx]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6pyx' size='340' side='right'caption='[[6pyx]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pyx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PYX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pyx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PYX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pyo\|6pyo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pyo\|6pyo]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pyx OCA], [http://pdbe.org/6pyx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pyx RCSB], [http://www.ebi.ac.uk/pdbsum/6pyx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pyx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pyx OCA], [http://pdbe.org/6pyx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pyx RCSB], [http://www.ebi.ac.uk/pdbsum/6pyx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pyx ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The secreted protein calcium-activated chloride channel regulator 1 (CLCA1) utilizes a von Willebrand factor type A (VWA) domain to bind to and potentiate the calcium-activated chloride channel TMEM16A. To gain insight into this unique potentiation mechanism, we determined the 2.0-A crystal structure of human CLCA1 VWA bound to Ca(2+). The structure reveals the metal-ion-dependent adhesion site (MIDAS) in a high-affinity "open" conformation, engaging in crystal contacts that likely mimic how CLCA1 engages TMEM16A. The CLCA1 VWA contains a disulfide bond between alpha3 and alpha4 in close proximity to the MIDAS that is invariant in the CLCA family and unique in VWA structures. Further biophysical studies indicate that CLCA1 VWA is preferably stabilized by Mg(2+) over Ca(2+) and that alpha6 atypically extends from the VWA core. Finally, an analysis of TMEM16A structures suggests residues likely to mediate interaction with CLCA1 VWA.
		+
		+	Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement.,Berry KN, Brett TJ Cell Rep. 2020 Jan 28;30(4):1141-1151.e3. doi: 10.1016/j.celrep.2019.12.059. Epub, 2020 Jan 28. PMID:31995732<ref>PMID:31995732</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6pyx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Berry, K B]]		[[Category: Berry, K B]]

OCA at 15:33, 29 January 2020

OCA — Wed, 29 Jan 2020 15:33:56 GMT

←Older revision		Revision as of 15:33, 29 January 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6pyx is ~~ON HOLD until Paper Publication~~	+	==Calcium Activated Chloride Channel Regulator 1 (CLCA1) VWA Domain==
-		+	<StructureSection load='6pyx' size='340' side='right'caption='[[6pyx]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~: ~~Brett~~, T.J., ~~Berry~~, K.B.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6pyx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PYX FirstGlance]. <br>
-	~~Description: Calcium Activated Chloride Channel Regulator 1 (CLCA1) VWA Domain~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pyo\|6pyo]]</td></tr>
-	[[Category: Berry, K.B]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pyx OCA], [http://pdbe.org/6pyx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pyx RCSB], [http://www.ebi.ac.uk/pdbsum/6pyx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pyx ProSAT]</span></td></tr>
-	[[Category: Brett, T.J]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Berry, K B]]
		+	[[Category: Brett, T J]]
		+	[[Category: Chloride channel regulator]]
		+	[[Category: Ion channel regulator]]
		+	[[Category: Protein transport]]
		+	[[Category: Vwa domain]]

OCA at 07:14, 25 December 2019

OCA — Wed, 25 Dec 2019 07:14:16 GMT

←Older revision		Revision as of 07:14, 25 December 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pyx is ON HOLD	+	The entry 6pyx is ON HOLD until Paper Publication

	Authors: Brett, T.J., Berry, K.B.		Authors: Brett, T.J., Berry, K.B.

OCA: Protected "6pyx" [edit=sysop:move=sysop]

OCA — Wed, 07 Aug 2019 04:21:25 GMT

Protected "6pyx" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:21, 7 August 2019

OCA: New page: '''Unreleased structure''' The entry 6pyx is ON HOLD Authors: Brett, T.J., Berry, K.B. Description: Calcium Activated Chloride Channel Regulator 1 (CLCA1) VWA Domain [[Category: Unrele...

OCA — Wed, 07 Aug 2019 04:21:24 GMT

New page: '''Unreleased structure''' The entry 6pyx is ON HOLD Authors: Brett, T.J., Berry, K.B. Description: Calcium Activated Chloride Channel Regulator 1 (CLCA1) VWA Domain [[Category: Unrele...

New page

'''Unreleased structure'''

The entry 6pyx is ON HOLD

Authors: Brett, T.J., Berry, K.B.

Description: Calcium Activated Chloride Channel Regulator 1 (CLCA1) VWA Domain
[[Category: Unreleased Structures]]
[[Category: Berry, K.B]]
[[Category: Brett, T.J]]