6pzb - Revision history

OCA at 04:44, 11 April 2020

OCA — Sat, 11 Apr 2020 04:44:33 GMT

←Older revision		Revision as of 04:44, 11 April 2020
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	<SX load='6pzb' size='340' side='right' viewer='molstar' caption='[[6pzb]], [[Resolution\|resolution]] 4.55Å' scene=''>		<SX load='6pzb' size='340' side='right' viewer='molstar' caption='[[6pzb]], [[Resolution\|resolution]] 4.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black-bellied_hamster Black-bellied hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black-bellied_hamster Black-bellied hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PZB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pz9\|6pz9]], [[6pza\|6pza]], [[6pzi\|6pzi]], [[6pzc\|6pzc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pz9\|6pz9]], [[6pza\|6pza]], [[6pzi\|6pzi]], [[6pzc\|6pzc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABCC8, SUR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10034 Black-bellied hamster])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABCC8, SUR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10034 Black-bellied hamster])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzb OCA], [http://pdbe.org/6pzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzb RCSB], [http://www.ebi.ac.uk/pdbsum/6pzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzb OCA], [http://pdbe.org/6pzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzb RCSB], [http://www.ebi.ac.uk/pdbsum/6pzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:31, 6 March 2020

OCA — Fri, 06 Mar 2020 23:31:15 GMT

←Older revision		Revision as of 23:31, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of the pancreatic beta-cell SUR1 Apo state==		==Cryo-EM structure of the pancreatic beta-cell SUR1 Apo state==
-	<~~StructureSection~~ load='6pzb' size='340' side='right'caption='[[6pzb]], [[Resolution\|resolution]] 4.55Å' scene=''>	+	<SX load='6pzb' size='340' side='right' viewer='molstar' caption='[[6pzb]], [[Resolution\|resolution]] 4.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6pzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black-bellied_hamster Black-bellied hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6pzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black-bellied_hamster Black-bellied hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZB FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Black-bellied hamster]]		[[Category: Black-bellied hamster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 13:09, 25 December 2019

OCA — Wed, 25 Dec 2019 13:09:37 GMT

←Older revision		Revision as of 13:09, 25 December 2019
Line 3:		Line 3:
	<StructureSection load='6pzb' size='340' side='right'caption='[[6pzb]], [[Resolution\|resolution]] 4.55Å' scene=''>		<StructureSection load='6pzb' size='340' side='right'caption='[[6pzb]], [[Resolution\|resolution]] 4.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pzb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black-bellied_hamster Black-bellied hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pz9\|6pz9]], [[6pza\|6pza]], [[6pzi\|6pzi]], [[6pzc\|6pzc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pz9\|6pz9]], [[6pza\|6pza]], [[6pzi\|6pzi]], [[6pzc\|6pzc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABCC8, SUR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10034 Black-bellied hamster])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzb OCA], [http://pdbe.org/6pzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzb RCSB], [http://www.ebi.ac.uk/pdbsum/6pzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzb OCA], [http://pdbe.org/6pzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzb RCSB], [http://www.ebi.ac.uk/pdbsum/6pzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzb ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Black-bellied hamster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Martin, G M]]		[[Category: Martin, G M]]

OCA at 16:43, 14 August 2019

OCA — Wed, 14 Aug 2019 16:43:38 GMT

←Older revision		Revision as of 16:43, 14 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6pzb is ~~ON HOLD~~	+	==Cryo-EM structure of the pancreatic beta-cell SUR1 Apo state==
		+	<StructureSection load='6pzb' size='340' side='right'caption='[[6pzb]], [[Resolution\|resolution]] 4.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6pzb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZB FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pz9\|6pz9]], [[6pza\|6pza]], [[6pzi\|6pzi]], [[6pzc\|6pzc]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzb OCA], [http://pdbe.org/6pzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzb RCSB], [http://www.ebi.ac.uk/pdbsum/6pzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzb ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ABCC8_CRICR ABCC8_CRICR]] Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive potassium channels and insulin release.[UniProtKB:Q09428]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic beta-cells to maintain glucose homeostasis. Mutations that impair channel folding or assembly prevent cell surface expression and cause congenital hyperinsulinism. Structurally diverse KATP inhibitors are known to act as pharmacochaperones to correct mutant channel expression, but the mechanism is unknown. Here, we compare cryoEM structures of a mammalian KATP channel bound to pharmacochaperones glibenclamide, repaglinide, and carbamazepine. We found all three drugs bind within a common pocket in SUR1. Further, we found the N-terminus of Kir6.2 inserted within the central cavity of the SUR1 ABC core, adjacent the drug binding pocket. The findings reveal a common mechanism by which diverse compounds stabilize the Kir6.2 N-terminus within SUR1's ABC core, allowing it to act as a firm 'handle' for the assembly of metastable mutant SUR1-Kir6.2 complexes.

-	~~Authors: Shyng, S.L~~., ~~Yoshioka~~, C., ~~Martin~~, ~~G.M.~~, ~~Sung~~, M.W.	+	Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM.,Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL Elife. 2019 Jul 25;8. pii: 46417. doi: 10.7554/eLife.46417. PMID:31343405<ref>PMID:31343405</ref>

-	~~Description: SUR1~~-~~Apo state~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6pzb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Martin, G M]]
		+	[[Category: Shyng, S L]]
		+	[[Category: Sung, M W]]
	[[Category: Yoshioka, C]]		[[Category: Yoshioka, C]]
-	[[Category: ~~Shyng, S.L~~]]	+	[[Category: Apo]]
-	[[Category: ~~Sung, M.W~~]]	+	[[Category: Katp]]
-	[[Category: ~~Martin, G.M~~]]	+	[[Category: Membrane protein]]
		+	[[Category: Sur1]]

OCA: Protected "6pzb" [edit=sysop:move=sysop]

OCA — Wed, 07 Aug 2019 04:22:43 GMT

Protected "6pzb" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:22, 7 August 2019

OCA: New page: '''Unreleased structure''' The entry 6pzb is ON HOLD Authors: Shyng, S.L., Yoshioka, C., Martin, G.M., Sung, M.W. Description: SUR1-Apo state Category: Unreleased Structures [[Cate...

OCA — Wed, 07 Aug 2019 04:22:41 GMT

New page: '''Unreleased structure''' The entry 6pzb is ON HOLD Authors: Shyng, S.L., Yoshioka, C., Martin, G.M., Sung, M.W. Description: SUR1-Apo state Category: Unreleased Structures [[Cate...

New page

'''Unreleased structure'''

The entry 6pzb is ON HOLD

Authors: Shyng, S.L., Yoshioka, C., Martin, G.M., Sung, M.W.

Description: SUR1-Apo state
[[Category: Unreleased Structures]]
[[Category: Yoshioka, C]]
[[Category: Shyng, S.L]]
[[Category: Sung, M.W]]
[[Category: Martin, G.M]]