6pzp - Revision history

OCA at 07:38, 11 October 2023

OCA — Wed, 11 Oct 2023 07:38:49 GMT

←Older revision		Revision as of 07:38, 11 October 2023
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-	====	+	==Crystal structure of caspase-1 in complex with VX-765==
-	<StructureSection load='6pzp' size='340' side='right'caption='[[6pzp]]' scene=''>	+	<StructureSection load='6pzp' size='340' side='right'caption='[[6pzp]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pzp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PZP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6pzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzp OCA], [~~http~~://pdbe.org/6pzp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pzp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pzp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzp ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.94Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P7S:N-(4-amino-3-chlorobenzene-1-carbonyl)-3-methyl-L-valyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-prolinamide'>P7S</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzp OCA], [https://pdbe.org/6pzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pzp RCSB], [https://www.ebi.ac.uk/pdbsum/6pzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzp ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
		+
		+	==See Also==
		+	*[[Caspase 3D structures\|Caspase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z~~-disk~~]]	+	[[Category: Liu Z]]
		+	[[Category: Xiao TS]]
		+	[[Category: Yang J]]

OCA at 05:32, 5 August 2020

OCA — Wed, 05 Aug 2020 05:32:44 GMT

←Older revision		Revision as of 05:32, 5 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6pzp ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6pzp' size='340' side='right'caption='[[6pzp]]' scene=''>
-	~~Authors~~: ~~Yang, J~~.~~, Liu, Z~~.~~, Xiao, T~~.S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: Crystal~~ structure ~~of caspase-1 in complex with VX-765~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzp OCA], [http://pdbe.org/6pzp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzp RCSB], [http://www.ebi.ac.uk/pdbsum/6pzp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzp ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Liu~~, Z]]	+	__TOC__
-	[[Category: ~~Yang, J~~]]	+	</StructureSection>
-	[[Category: ~~Xiao, T.S~~]]	+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 03:39, 10 October 2019

OCA — Thu, 10 Oct 2019 03:39:05 GMT

←Older revision		Revision as of 03:39, 10 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pzp is ON HOLD	+	The entry 6pzp is ON HOLD until Paper Publication

	Authors: Yang, J., Liu, Z., Xiao, T.S.		Authors: Yang, J., Liu, Z., Xiao, T.S.

OCA at 04:14, 21 August 2019

OCA — Wed, 21 Aug 2019 04:14:09 GMT

←Older revision		Revision as of 04:14, 21 August 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pzp is ON HOLD ~~until sometime in the future~~	+	The entry 6pzp is ON HOLD

	Authors: Yang, J., Liu, Z., Xiao, T.S.		Authors: Yang, J., Liu, Z., Xiao, T.S.

OCA at 15:02, 14 August 2019

OCA — Wed, 14 Aug 2019 15:02:54 GMT

←Older revision		Revision as of 15:02, 14 August 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pzp is ON HOLD	+	The entry 6pzp is ON HOLD until sometime in the future

	Authors: Yang, J., Liu, Z., Xiao, T.S.		Authors: Yang, J., Liu, Z., Xiao, T.S.

OCA: Protected "6pzp" [edit=sysop:move=sysop]

OCA — Wed, 07 Aug 2019 04:23:32 GMT

Protected "6pzp" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:23, 7 August 2019

OCA: New page: '''Unreleased structure''' The entry 6pzp is ON HOLD Authors: Yang, J., Liu, Z., Xiao, T.S. Description: Crystal structure of caspase-1 in complex with VX-765 [[Category: Unreleased St...

OCA — Wed, 07 Aug 2019 04:23:31 GMT

New page: '''Unreleased structure''' The entry 6pzp is ON HOLD Authors: Yang, J., Liu, Z., Xiao, T.S. Description: Crystal structure of caspase-1 in complex with VX-765 [[Category: Unreleased St...

New page

'''Unreleased structure'''

The entry 6pzp is ON HOLD

Authors: Yang, J., Liu, Z., Xiao, T.S.

Description: Crystal structure of caspase-1 in complex with VX-765
[[Category: Unreleased Structures]]
[[Category: Liu, Z]]
[[Category: Yang, J]]
[[Category: Xiao, T.S]]