6pzz - Revision history

OCA at 06:35, 7 April 2023

OCA — Fri, 07 Apr 2023 06:35:46 GMT

←Older revision		Revision as of 06:35, 7 April 2023
Line 3:		Line 3:
	<SX load='6pzz' size='340' side='right' viewer='molstar' caption='[[6pzz]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='6pzz' size='340' side='right' viewer='molstar' caption='[[6pzz]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pzz]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/environment/~~shanghai~~/~~s1439~~/2013(~~h7n9~~)) Influenza a virus (a/environment/~~shanghai~~/~~s1439~~/2013(~~h7n9~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6PZZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pzz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/environment/Shanghai/S1439/2013(H7N9)) Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PZZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1347105 Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9))])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzz OCA], [https://pdbe.org/6pzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pzz RCSB], [https://www.ebi.ac.uk/pdbsum/6pzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzz ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzz OCA], [~~http~~://pdbe.org/6pzz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pzz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pzz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/S5MF06_9INFA S5MF06_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071][SAAS:SAAS00844152]	+	[https://www.uniprot.org/uniprot/S5MF06_9INFA S5MF06_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071][SAAS:SAAS00844152]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6pzz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6pzz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Exo-alpha-sialidase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Turner~~, H L~~]]	+	[[Category: Turner HL]]
-	[[Category: Ward~~, A B~~]]	+	[[Category: Ward AB]]
-	[[Category: Zhu, X]]	+	[[Category: Zhu X]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: H7n9]]~~	+
-	~~[[Category: Influenza]]~~	+
-	~~[[Category: N9sh2]]~~	+
-	~~[[Category: N9shanghai]]~~	+
-	~~[[Category: Na]]~~	+
-	~~[[Category: Na-80]]~~	+
-	~~[[Category: Neuraminidase]]~~	+
-	~~[[Category: Sh2]]~~	+
-	~~[[Category: Viral protein-immune system complex~~]]	+

OCA at 04:45, 11 April 2020

OCA — Sat, 11 Apr 2020 04:45:43 GMT

←Older revision		Revision as of 04:45, 11 April 2020
Line 3:		Line 3:
	<SX load='6pzz' size='340' side='right' viewer='molstar' caption='[[6pzz]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='6pzz' size='340' side='right' viewer='molstar' caption='[[6pzz]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pzz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/environment/shanghai/s1439/2013(h7n9)) Influenza a virus (a/environment/shanghai/s1439/2013(h7n9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PZZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pzz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/environment/shanghai/s1439/2013(h7n9)) Influenza a virus (a/environment/shanghai/s1439/2013(h7n9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PZZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1347105 Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9))])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1347105 Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9))])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzz OCA], [http://pdbe.org/6pzz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzz RCSB], [http://www.ebi.ac.uk/pdbsum/6pzz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzz OCA], [http://pdbe.org/6pzz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzz RCSB], [http://www.ebi.ac.uk/pdbsum/6pzz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:32, 6 March 2020

OCA — Fri, 06 Mar 2020 23:32:06 GMT

←Older revision		Revision as of 23:32, 6 March 2020
Line 1:		Line 1:

	==CryoEM derived model of NA-80 Fab in complex with N9 Shanghai2==		==CryoEM derived model of NA-80 Fab in complex with N9 Shanghai2==
-	<~~StructureSection~~ load='6pzz' size='340' side='right'caption='[[6pzz]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<SX load='6pzz' size='340' side='right' viewer='molstar' caption='[[6pzz]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6pzz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/environment/shanghai/s1439/2013(h7n9)) Influenza a virus (a/environment/shanghai/s1439/2013(h7n9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6pzz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/environment/shanghai/s1439/2013(h7n9)) Influenza a virus (a/environment/shanghai/s1439/2013(h7n9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZZ FirstGlance]. <br>
Line 23:		Line 23:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Human]]		[[Category: Human]]

OCA at 13:10, 25 December 2019

OCA — Wed, 25 Dec 2019 13:10:51 GMT

←Older revision		Revision as of 13:10, 25 December 2019
Line 3:		Line 3:
	<StructureSection load='6pzz' size='340' side='right'caption='[[6pzz]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='6pzz' size='340' side='right'caption='[[6pzz]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pzz]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pzz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/environment/shanghai/s1439/2013(h7n9)) Influenza a virus (a/environment/shanghai/s1439/2013(h7n9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1347105 Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9))])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzz OCA], [http://pdbe.org/6pzz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzz RCSB], [http://www.ebi.ac.uk/pdbsum/6pzz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzz OCA], [http://pdbe.org/6pzz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzz RCSB], [http://www.ebi.ac.uk/pdbsum/6pzz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzz ProSAT]</span></td></tr>
Line 24:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Turner, H L]]		[[Category: Turner, H L]]

OCA at 08:15, 4 December 2019

OCA — Wed, 04 Dec 2019 08:15:33 GMT

←Older revision		Revision as of 08:15, 4 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6pzz is ~~ON HOLD until Paper~~ Publication	+	==CryoEM derived model of NA-80 Fab in complex with N9 Shanghai2==
		+	<StructureSection load='6pzz' size='340' side='right'caption='[[6pzz]], [[Resolution\|resolution]] 3.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6pzz]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzz OCA], [http://pdbe.org/6pzz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pzz RCSB], [http://www.ebi.ac.uk/pdbsum/6pzz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzz ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/S5MF06_9INFA S5MF06_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071][SAAS:SAAS00844152]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Influenza virus neuraminidase (NA) is a major target for small-molecule antiviral drugs. Antibodies targeting the NA surface antigen could also inhibit virus entry and egress to provide host protection. However, our understanding of the nature and range of target epitopes is limited because of a lack of human antibody structures with influenza neuraminidase. Here, we describe crystal and cryogenic electron microscopy (cryo-EM) structures of NAs from human-infecting avian H7N9 viruses in complex with five human anti-N9 antibodies, systematically defining several antigenic sites and antibody epitope footprints. These antibodies either fully or partially block the NA active site or bind to epitopes distant from the active site while still showing neuraminidase inhibition. The inhibition of antibodies to NAs was further analyzed by glycan array and solution-based NA activity assays. Together, these structural studies provide insights into protection by anti-NA antibodies and templates for the development of NA-based influenza virus vaccines and therapeutics.

-	~~Authors~~:	+	Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.,Zhu X, Turner HL, Lang S, McBride R, Bangaru S, Gilchuk IM, Yu W, Paulson JC, Crowe JE Jr, Ward AB, Wilson IA Cell Host Microbe. 2019 Oct 24. pii: S1931-3128(19)30526-8. doi:, 10.1016/j.chom.2019.10.002. PMID:31757767<ref>PMID:31757767</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6pzz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Exo-alpha-sialidase]]
		+	[[Category: Large Structures]]
		+	[[Category: Turner, H L]]
		+	[[Category: Ward, A B]]
		+	[[Category: Zhu, X]]
		+	[[Category: Antibody]]
		+	[[Category: Fab]]
		+	[[Category: H7n9]]
		+	[[Category: Influenza]]
		+	[[Category: N9sh2]]
		+	[[Category: N9shanghai]]
		+	[[Category: Na]]
		+	[[Category: Na-80]]
		+	[[Category: Neuraminidase]]
		+	[[Category: Sh2]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 07:16, 2 October 2019

OCA — Wed, 02 Oct 2019 07:16:50 GMT

←Older revision		Revision as of 07:16, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6pzz is ON HOLD	+	The entry 6pzz is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6pzz" [edit=sysop:move=sysop]

OCA — Wed, 07 Aug 2019 04:24:07 GMT

Protected "6pzz" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:24, 7 August 2019

OCA: New page: '''Unreleased structure''' The entry 6pzz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 07 Aug 2019 04:24:06 GMT

New page: '''Unreleased structure''' The entry 6pzz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6pzz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]