6q0g - Revision history

OCA at 07:39, 11 October 2023

OCA — Wed, 11 Oct 2023 07:39:07 GMT

←Older revision		Revision as of 07:39, 11 October 2023
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	<StructureSection load='6q0g' size='340' side='right'caption='[[6q0g]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6q0g' size='340' side='right'caption='[[6q0g]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q0g]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Psepf Psepf~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q0G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6Q0G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q0g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens_Pf0-1 Pseudomonas fluorescens Pf0-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q0G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=PRO:PROLINE'>PRO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Pfl01_4431 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=205922 PSEPF])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6q0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q0g OCA], [~~http~~://pdbe.org/6q0g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6q0g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6q0g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6q0g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q0g OCA], [https://pdbe.org/6q0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q0g RCSB], [https://www.ebi.ac.uk/pdbsum/6q0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q0g ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q3K7T6_PSEPF Q3K7T6_PSEPF]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Psepf~~]]	+	[[Category: Pseudomonas fluorescens Pf0-1]]
-	[[Category: Khan~~, M F~~]]	+	[[Category: Khan MF]]
-	[[Category: Roujeinikova, A]]	+	[[Category: Roujeinikova A]]
-	[[Category: Ud-Din~~, I A]]~~	+	[[Category: Ud-Din IA]]
-	~~[[Category: Bacterial chemotaxis]]~~	+
-	~~[[Category: Chemoreceptor]]~~	+
-	~~[[Category: Double cache]]~~	+
-	~~[[Category: Ligand binding domain]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:16, 15 April 2020

OCA — Wed, 15 Apr 2020 07:16:02 GMT

←Older revision		Revision as of 07:16, 15 April 2020
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	<StructureSection load='6q0g' size='340' side='right'caption='[[6q0g]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6q0g' size='340' side='right'caption='[[6q0g]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q0g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q0G OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6Q0G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Psepf Psepf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q0G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Q0G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6q0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q0g OCA], [http://pdbe.org/6q0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q0g RCSB], [http://www.ebi.ac.uk/pdbsum/6q0g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q0g ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfl01_4431 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=205922 PSEPF])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6q0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q0g OCA], [http://pdbe.org/6q0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q0g RCSB], [http://www.ebi.ac.uk/pdbsum/6q0g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q0g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Psepf]]
	[[Category: Khan, M F]]		[[Category: Khan, M F]]
	[[Category: Roujeinikova, A]]		[[Category: Roujeinikova, A]]

OCA at 09:45, 18 March 2020

OCA — Wed, 18 Mar 2020 09:45:15 GMT

←Older revision		Revision as of 09:45, 18 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6q0g is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of ligand-binding domain of Pseudomonas fluorescens chemoreceptor CtaA in complex with L-proline==
		+	<StructureSection load='6q0g' size='340' side='right'caption='[[6q0g]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6q0g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q0G FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q0g OCA], [http://pdbe.org/6q0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q0g RCSB], [http://www.ebi.ac.uk/pdbsum/6q0g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q0g ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Motile bacteria follow gradients of nutrients or other environmental cues. Many bacterial chemoreceptors that sense exogenous amino acids contain a double Cache (dCache; calcium channels and chemotaxis receptors) ligand-binding domain (LBD). A growing number of studies suggest that broad-specificity dCache-type receptors that sense more than one amino acid are common. Here, we present an investigation into the mechanism by which the dCache LBD of the chemoreceptor CtaA from a plant growth-promoting rhizobacterium, Pseudomonas fluorescens, recognizes several chemically distinct amino acids. We established that amino acids that signal by directly binding to the CtaA LBD include ones with aliphatic (l-alanine, l-proline, l-leucine, l-isoleucine, l-valine), small polar (l-serine), and large charged (l-arginine) side chains. We determined the structure of CtaA LBD in complex with different amino acids, revealing that its ability to recognize a range of structurally and chemically distinct amino acids is afforded by its easily accessible plastic pocket, which can expand or contract according to the size of the ligand side chain. The amphipathic character of the pocket enables promiscuous interactions with both polar and nonpolar amino acids. The results not only clarify the means by which various amino acids are recognized by CtaA but also reveal that a conserved mobile lid over the ligand-binding pocket adopts the same conformation in all complexes, consistent with this being an important and invariant part of the signaling mechanism.

-	~~Authors:~~ Ud-Din~~, I.A.~~, Khan, M.F., ~~Roujeinikova, A~~.	+	Broad Specificity of Amino Acid Chemoreceptor CtaA of Pseudomonas fluorescens Is Afforded by Plasticity of Its Amphipathic Ligand-Binding Pocket.,Ud-Din AIMS, Khan MF, Roujeinikova A Mol Plant Microbe Interact. 2020 Feb 19:MPMI10190277R. doi:, 10.1094/MPMI-10-19-0277-R. PMID:31909676<ref>PMID:31909676</ref>

-	~~Description: Crystal structure~~ of ~~ligand-binding domain~~ of ~~Pseudomonas fluorescens chemoreceptor CtaA in complex with L~~-~~proline~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Khan, M.F]]	+	<div class="pdbe-citations 6q0g" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Khan, M F]]
	[[Category: Roujeinikova, A]]		[[Category: Roujeinikova, A]]
-	[[Category: Ud-Din, I.A]]	+	[[Category: Ud-Din, I A]]
		+	[[Category: Bacterial chemotaxis]]
		+	[[Category: Chemoreceptor]]
		+	[[Category: Double cache]]
		+	[[Category: Ligand binding domain]]
		+	[[Category: Signaling protein]]

OCA at 13:47, 28 August 2019

OCA — Wed, 28 Aug 2019 13:47:56 GMT

←Older revision		Revision as of 13:47, 28 August 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6q0g is ON HOLD	+	The entry 6q0g is ON HOLD until Paper Publication

	Authors: Ud-Din, I.A., Khan, M.F., Roujeinikova, A.		Authors: Ud-Din, I.A., Khan, M.F., Roujeinikova, A.

OCA: Protected "6q0g" [edit=sysop:move=sysop]

OCA — Wed, 07 Aug 2019 04:25:36 GMT

Protected "6q0g" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:25, 7 August 2019

OCA: New page: '''Unreleased structure''' The entry 6q0g is ON HOLD Authors: Ud-Din, I.A., Khan, M.F., Roujeinikova, A. Description: Crystal structure of ligand-binding domain of Pseudomonas fluoresc...

OCA — Wed, 07 Aug 2019 04:25:34 GMT

New page: '''Unreleased structure''' The entry 6q0g is ON HOLD Authors: Ud-Din, I.A., Khan, M.F., Roujeinikova, A. Description: Crystal structure of ligand-binding domain of Pseudomonas fluoresc...

New page

'''Unreleased structure'''

The entry 6q0g is ON HOLD

Authors: Ud-Din, I.A., Khan, M.F., Roujeinikova, A.

Description: Crystal structure of ligand-binding domain of Pseudomonas fluorescens chemoreceptor CtaA in complex with L-proline
[[Category: Unreleased Structures]]
[[Category: Khan, M.F]]
[[Category: Roujeinikova, A]]
[[Category: Ud-Din, I.A]]