6q14 - Revision history

OCA at 04:47, 11 April 2020

OCA — Sat, 11 Apr 2020 04:47:33 GMT

←Older revision		Revision as of 04:47, 11 April 2020
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	<SX load='6q14' size='340' side='right' viewer='molstar' caption='[[6q14]], [[Resolution\|resolution]] 3.80Å' scene=''>		<SX load='6q14' size='340' side='right' viewer='molstar' caption='[[6q14]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q14]] is a 74 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q14 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6Q14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q14]] is a 74 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q14 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Q14 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pee\|6pee]], [[6pem\|6pem]], [[6pep\|6pep]], [[6q15\|6q15]], [[6q16\|6q16]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pee\|6pee]], [[6pem\|6pem]], [[6pep\|6pep]], [[6q15\|6q15]], [[6q16\|6q16]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6q14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q14 OCA], [http://pdbe.org/6q14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q14 RCSB], [http://www.ebi.ac.uk/pdbsum/6q14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q14 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6q14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q14 OCA], [http://pdbe.org/6q14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q14 RCSB], [http://www.ebi.ac.uk/pdbsum/6q14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q14 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:32, 6 March 2020

OCA — Fri, 06 Mar 2020 23:32:36 GMT

←Older revision		Revision as of 23:32, 6 March 2020
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	==Structure of the Salmonella SPI-1 injectisome NC-base==		==Structure of the Salmonella SPI-1 injectisome NC-base==
-	<~~StructureSection~~ load='6q14' size='340' side='right'caption='[[6q14]], [[Resolution\|resolution]] 3.80Å' scene=''>	+	<SX load='6q14' size='340' side='right' viewer='molstar' caption='[[6q14]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6q14]] is a 74 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q14 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6q14]] is a 74 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q14 FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Salty]]		[[Category: Salty]]

OCA at 08:36, 6 November 2019

OCA — Wed, 06 Nov 2019 08:36:53 GMT

←Older revision		Revision as of 08:36, 6 November 2019
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	<StructureSection load='6q14' size='340' side='right'caption='[[6q14]], [[Resolution\|resolution]] 3.80Å' scene=''>		<StructureSection load='6q14' size='340' side='right'caption='[[6q14]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q14]] is a 74 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Salmonella_typhimurium_(strain_lt2_/_sgsc1412_/_atcc_700720) Salmonella typhimurium (strain lt2 / sgsc1412 / atcc 700720)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q14]] is a 74 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q14 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pee\|6pee]], [[6pem\|6pem]], [[6pep\|6pep]], [[6q15\|6q15]], [[6q16\|6q16]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pee\|6pee]], [[6pem\|6pem]], [[6pep\|6pep]], [[6q15\|6q15]], [[6q16\|6q16]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q14 OCA], [http://pdbe.org/6q14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q14 RCSB], [http://www.ebi.ac.uk/pdbsum/6q14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q14 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q14 OCA], [http://pdbe.org/6q14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q14 RCSB], [http://www.ebi.ac.uk/pdbsum/6q14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q14 ProSAT]</span></td></tr>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Salty]]
	[[Category: Hu, J]]		[[Category: Hu, J]]
	[[Category: Strynadka, N C.J]]		[[Category: Strynadka, N C.J]]

OCA at 07:00, 23 October 2019

OCA — Wed, 23 Oct 2019 07:00:52 GMT

←Older revision		Revision as of 07:00, 23 October 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6q14 is ~~ON HOLD until Paper~~ Publication	+	==Structure of the Salmonella SPI-1 injectisome NC-base==
		+	<StructureSection load='6q14' size='340' side='right'caption='[[6q14]], [[Resolution\|resolution]] 3.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6q14]] is a 74 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium_(strain_lt2_/_sgsc1412_/_atcc_700720) Salmonella typhimurium (strain lt2 / sgsc1412 / atcc 700720)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q14 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6pee\|6pee]], [[6pem\|6pem]], [[6pep\|6pep]], [[6q15\|6q15]], [[6q16\|6q16]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q14 OCA], [http://pdbe.org/6q14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q14 RCSB], [http://www.ebi.ac.uk/pdbsum/6q14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q14 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/INVG_SALTY INVG_SALTY]] Involved in the invasion of the cells of the intestinal epithelium. Could be necessary for the export of invasion related determinants. [[http://www.uniprot.org/uniprot/SPAQ_SALTY SPAQ_SALTY]] Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. [[http://www.uniprot.org/uniprot/PRGK_SALTY PRGK_SALTY]] Required for invasion of epithelial cells. Could be involved in protein secretion. [[http://www.uniprot.org/uniprot/SPAR_SALTY SPAR_SALTY]] Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. [[http://www.uniprot.org/uniprot/SPAP_SALTY SPAP_SALTY]] Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. [[http://www.uniprot.org/uniprot/PRGH_SALTY PRGH_SALTY]] Required for invasion of epithelial cells.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial injectisome is a syringe-shaped macromolecular nanomachine utilized by many pathogenic Gram-negative bacteria, including the causative agents of plague, typhoid fever, whooping cough, sexually transmitted infections and major nosocomial infections. Bacterial proteins destined for self-assembly and host-cell targeting are translocated by the injectisome in a process known as type III secretion (T3S). The core structure is the ~4 MDa needle complex (NC), built on a foundation of three highly oligomerized ring-forming proteins that create a hollow scaffold spanning the bacterial inner membrane (IM) (24-mer ring-forming proteins PrgH and PrgK in the Salmonella enterica serovar Typhimurium Salmonella pathogenicity island 1 (SPI-1) type III secretion system (T3SS)) and outer membrane (OM) (15-mer InvG, a member of the broadly conserved secretin pore family). An internalized helical needle projects from the NC and bacterium, ultimately forming a continuous passage to the host, for delivery of virulence effectors. Here, we have captured snapshots of the entire prototypical SPI-1 NC in four distinct needle assembly states, including near-atomic resolution, and local reconstructions in the absence and presence of the needle. These structures reveal the precise localization and molecular interactions of the internalized SpaPQR 'export apparatus' complex, which is intimately encapsulated and stabilized within the IM rings in the manner of a nanodisc, and to which the PrgJ rod directly binds and functions as an initiator and anchor of needle polymerization. We also describe the molecular details of the extensive and continuous coupling interface between the OM secretin and IM rings, which is remarkably facilitated by a localized 16-mer stoichiometry in the periplasmic-most coupling domain of the otherwise 15-mer InvG oligomer.

-	~~Authors~~:	+	T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.,Hu J, Worrall LJ, Vuckovic M, Hong C, Deng W, Atkinson CE, Brett Finlay B, Yu Z, Strynadka NCJ Nat Microbiol. 2019 Aug 19. pii: 10.1038/s41564-019-0545-z. doi:, 10.1038/s41564-019-0545-z. PMID:31427728<ref>PMID:31427728</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6q14" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hu, J]]
		+	[[Category: Strynadka, N C.J]]
		+	[[Category: Worrall, L J]]
		+	[[Category: Bacterial secretion]]
		+	[[Category: Protein transport]]
		+	[[Category: Type iii secretion]]

OCA at 07:17, 2 October 2019

OCA — Wed, 02 Oct 2019 07:17:45 GMT

←Older revision		Revision as of 07:17, 2 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6q14 is ON HOLD	+	The entry 6q14 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6q14" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2019 15:03:54 GMT

Protected "6q14" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:03, 14 August 2019

OCA: New page: '''Unreleased structure''' The entry 6q14 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Aug 2019 15:03:53 GMT

New page: '''Unreleased structure''' The entry 6q14 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6q14 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]