6q1e - Revision history

OCA at 12:13, 1 January 2020

OCA — Wed, 01 Jan 2020 12:13:07 GMT

←Older revision		Revision as of 12:13, 1 January 2020
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	<StructureSection load='6q1e' size='340' side='right'caption='[[6q1e]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6q1e' size='340' side='right'caption='[[6q1e]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q1e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q1E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q1e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q1E FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q1e OCA], [http://pdbe.org/6q1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q1e RCSB], [http://www.ebi.ac.uk/pdbsum/6q1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q1e ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q1e OCA], [http://pdbe.org/6q1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q1e RCSB], [http://www.ebi.ac.uk/pdbsum/6q1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q1e ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Affinity maturation of the B cell antigen receptor (BCR) is a conserved and crucial component of the adaptive immune response. BCR lineages, inferred from paired heavy- and light-chain sequences of rearranged Ig genes from multiple descendants of the same naive B cell precursor (the lineages' unmutated common ancestor, "UCA"), make it possible to reconstruct the underlying somatic evolutionary history. We present here an extensive structural and biophysical analysis of a lineage of BCRs directed against the receptor binding site (RBS) of subtype H1 influenza virus hemagglutinin (HA). The lineage includes 8 antibodies detected directly by sequencing, 3 in 1 principal branch and 5 in the other. When bound to HA, the heavy-chain third complementarity determining region (HCDR3) fits with an invariant pose into the RBS, but in each of the 2 branches, the rest of the Fab reorients specifically, from its position in the HA-bound UCA, about a hinge at the base of HCDR3. New contacts generated by the reorientation compensate for contacts lost as the H1 HA mutated during the time between the donor's initial exposure and the vaccination that preceded sampling. Our data indicate that a "pluripotent" naive response differentiated, in each branch, into 1 of its possible alternatives. This property of naive BCRs and persistence of multiple branches of their progeny lineages can offer broader protection from evolving pathogens than can a single, linear pathway of somatic mutation.
		+
		+	Affinity maturation in a human humoral response to influenza hemagglutinin.,McCarthy KR, Raymond DD, Do KT, Schmidt AG, Harrison SC Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 1915620116. doi:, 10.1073/pnas.1915620116. PMID:31843892<ref>PMID:31843892</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6q1e" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]

OCA at 07:49, 18 December 2019

OCA — Wed, 18 Dec 2019 07:49:00 GMT

←Older revision		Revision as of 07:49, 18 December 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6q1e is ~~ON HOLD until Paper Publication~~	+	==Inferred precursor (UCA) of the human antibody lineage 652==
-		+	<StructureSection load='6q1e' size='340' side='right'caption='[[6q1e]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6q1e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q1E FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q1e OCA], [http://pdbe.org/6q1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q1e RCSB], [http://www.ebi.ac.uk/pdbsum/6q1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q1e ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Harrison, S C]]
		+	[[Category: McCarthy, K R]]
		+	[[Category: Antibody]]
		+	[[Category: Immune system]]

OCA at 07:18, 2 October 2019

OCA — Wed, 02 Oct 2019 07:18:10 GMT

←Older revision		Revision as of 07:18, 2 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6q1e is ON HOLD	+	The entry 6q1e is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6q1e" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2019 15:04:35 GMT

Protected "6q1e" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:04, 14 August 2019

OCA: New page: '''Unreleased structure''' The entry 6q1e is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Aug 2019 15:04:34 GMT

New page: '''Unreleased structure''' The entry 6q1e is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6q1e is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]