6q5z - Revision history

OCA at 10:59, 14 June 2023

OCA — Wed, 14 Jun 2023 10:59:40 GMT

←Older revision		Revision as of 10:59, 14 June 2023
Line 1:		Line 1:

	==H-Vc7.2, H-superfamily conotoxin==		==H-Vc7.2, H-superfamily conotoxin==
-	<StructureSection load='6q5z' size='340' side='right'caption='[[6q5z~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6q5z' size='340' side='right'caption='[[6q5z]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q5z]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Convc Convc~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q5Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6Q5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_victoriae Conus victoriae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q5Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6q5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q5z OCA], [~~http~~://pdbe.org/6q5z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6q5z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6q5z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6q5z ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q5z OCA], [https://pdbe.org/6q5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q5z RCSB], [https://www.ebi.ac.uk/pdbsum/6q5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q5z ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/H72_CONVC H72_CONVC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Convc~~]]	+	[[Category: Conus victoriae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ellgaard, L]]	+	[[Category: Ellgaard L]]
-	[[Category: Foged~~, M M~~]]	+	[[Category: Foged MM]]
-	[[Category: Nielsen~~, L D~~]]	+	[[Category: Nielsen LD]]
-	[[Category: Teilum, K]]	+	[[Category: Teilum K]]
-	~~[[Category: Cysteine framework vi/vii]]~~	+
-	~~[[Category: Cysteine rich]]~~	+
-	~~[[Category: Mini-granulin fold]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 08:24, 24 April 2019

OCA — Wed, 24 Apr 2019 08:24:39 GMT

←Older revision		Revision as of 08:24, 24 April 2019
Line 3:		Line 3:
	<StructureSection load='6q5z' size='340' side='right'caption='[[6q5z]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6q5z' size='340' side='right'caption='[[6q5z]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q5z]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Convc Convc]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q5Z FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q5z OCA], [http://pdbe.org/6q5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q5z RCSB], [http://www.ebi.ac.uk/pdbsum/6q5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q5z ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q5z OCA], [http://pdbe.org/6q5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q5z RCSB], [http://www.ebi.ac.uk/pdbsum/6q5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q5z ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Venomous marine cone snails produce peptide toxins (conotoxins) that bind ion channels and receptors with high specificity and therefore are important pharmacological tools. Conotoxins contain conserved cysteine residues that form disulfide bonds that stabilize their structures. To gain structural insight into the large, yet poorly characterized conotoxin H-superfamily, we used NMR and CD spectroscopy along with MS-based analyses to investigate H-Vc7.2 from Conus victoriae, a peptide with a VI/VII cysteine framework. This framework has Cys(I)-Cys(IV)/Cys(II)-Cys(V)/Cys(III)-Cys(VI) connectivities, which have invariably been associated with the inhibitor cystine knot (ICK) fold. However, the solution structure of recombinantly expressed and purified H-Vc7.2 revealed that although it displays the expected cysteine connectivities, H-Vc7.2 adopts a different fold consisting of two stacked beta-hairpins with opposing beta-strands connected by two parallel disulfide bonds, a structure homologous to the N-terminal region of the human granulin protein. Using structural comparisons, we subsequently identified several toxins and nontoxin proteins with this "mini-granulin" fold. These findings raise fundamental questions concerning sequence-structure relationships within peptides and proteins and the key determinants that specify a given fold.
		+
		+	The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework.,Nielsen LD, Foged MM, Albert A, Bertelsen AB, Soltoft CL, Robinson SD, Petersen SV, Purcell AW, Olivera BM, Norton RS, Vasskog T, Safavi-Hemami H, Teilum K, Ellgaard L J Biol Chem. 2019 Apr 11. pii: RA119.007491. doi: 10.1074/jbc.RA119.007491. PMID:30975904<ref>PMID:30975904</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6q5z" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Convc]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ellgaard, L]]		[[Category: Ellgaard, L]]

OCA at 06:08, 17 April 2019

OCA — Wed, 17 Apr 2019 06:08:17 GMT

←Older revision		Revision as of 06:08, 17 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6q5z ~~is ON HOLD~~	+	==H-Vc7.2, H-superfamily conotoxin==
-		+	<StructureSection load='6q5z' size='340' side='right'caption='[[6q5z]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~: ~~Nielsen, L~~.D.~~, Foged, M~~.M.~~, Teilum, K~~.~~, Ellgaard, L~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6q5z]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q5Z FirstGlance]. <br>
-	~~Description~~: H-~~Vc7~~.2, H-~~superfamily conotoxin~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q5z OCA], [http://pdbe.org/6q5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q5z RCSB], [http://www.ebi.ac.uk/pdbsum/6q5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q5z ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Nielsen, L~~.D]]	+	__TOC__
-	[[Category: ~~Foged, M.M~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ellgaard, L]]		[[Category: Ellgaard, L]]
		+	[[Category: Foged, M M]]
		+	[[Category: Nielsen, L D]]
	[[Category: Teilum, K]]		[[Category: Teilum, K]]
		+	[[Category: Cysteine framework vi/vii]]
		+	[[Category: Cysteine rich]]
		+	[[Category: Mini-granulin fold]]
		+	[[Category: Toxin]]

OCA: Protected "6q5z" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2018 06:44:52 GMT

Protected "6q5z" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:44, 19 December 2018

OCA: New page: '''Unreleased structure''' The entry 6q5z is ON HOLD Authors: Nielsen, L.D., Foged, M.M., Teilum, K., Ellgaard, L. Description: H-Vc7.2, H-superfamily conotoxin [[Category: Unreleased ...

OCA — Wed, 19 Dec 2018 06:44:50 GMT

New page: '''Unreleased structure''' The entry 6q5z is ON HOLD Authors: Nielsen, L.D., Foged, M.M., Teilum, K., Ellgaard, L. Description: H-Vc7.2, H-superfamily conotoxin [[Category: Unreleased ...

New page

'''Unreleased structure'''

The entry 6q5z is ON HOLD

Authors: Nielsen, L.D., Foged, M.M., Teilum, K., Ellgaard, L.

Description: H-Vc7.2, H-superfamily conotoxin
[[Category: Unreleased Structures]]
[[Category: Nielsen, L.D]]
[[Category: Foged, M.M]]
[[Category: Ellgaard, L]]
[[Category: Teilum, K]]