6q60 - Revision history

OCA at 11:53, 24 January 2024

OCA — Wed, 24 Jan 2024 11:53:34 GMT

←Older revision		Revision as of 11:53, 24 January 2024
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	<StructureSection load='6q60' size='340' side='right'caption='[[6q60]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='6q60' size='340' side='right'caption='[[6q60]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q60]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q60 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6Q60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q60 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HJH:(2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic+acid'>HJH</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gria2, Glur2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HJH:(2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic+acid'>HJH</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6q60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q60 OCA], [~~http~~://pdbe.org/6q60 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6q60 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6q60 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6q60 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q60 OCA], [https://pdbe.org/6q60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q60 RCSB], [https://www.ebi.ac.uk/pdbsum/6q60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q60 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>	+	[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6q60" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6q60" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kastrup, J S~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Moellerud, S~~]]	+	[[Category: Kastrup JS]]
-	[[Category: ~~Temperini, P~~]]	+	[[Category: Moellerud S]]
-	[[Category: ~~Agonist]]~~	+	[[Category: Temperini P]]
-	~~[[Category: Ampa receptor]]~~	+
-	~~[[Category: Glua2-s1s2]]~~	+
-	~~[[Category: Ligand binding domain]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 07:41, 23 May 2019

OCA — Thu, 23 May 2019 07:41:08 GMT

←Older revision		Revision as of 07:41, 23 May 2019
Line 3:		Line 3:
	<StructureSection load='6q60' size='340' side='right'caption='[[6q60]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='6q60' size='340' side='right'caption='[[6q60]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q60]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q60 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HJH:(2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic+acid'>HJH</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HJH:(2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic+acid'>HJH</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gria2, Glur2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q60 OCA], [http://pdbe.org/6q60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q60 RCSB], [http://www.ebi.ac.uk/pdbsum/6q60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q60 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q60 OCA], [http://pdbe.org/6q60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q60 RCSB], [http://www.ebi.ac.uk/pdbsum/6q60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q60 ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kastrup, J S]]		[[Category: Kastrup, J S]]

OCA at 06:08, 17 April 2019

OCA — Wed, 17 Apr 2019 06:08:37 GMT

←Older revision		Revision as of 06:08, 17 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6q60 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution==
		+	<StructureSection load='6q60' size='340' side='right'caption='[[6q60]], [[Resolution\|resolution]] 1.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6q60]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q60 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HJH:(2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic+acid'>HJH</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q60 OCA], [http://pdbe.org/6q60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q60 RCSB], [http://www.ebi.ac.uk/pdbsum/6q60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q60 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report a series of glutamate and aspartate analogues designed using the hydroxy-1,2,3-triazole moiety as a bioisostere for the distal carboxylic acid. Compound 6b showed unprecedented selectivity among AMPA receptor subtypes, confirmed also by an unusual binding mode observed on the crystal structures in complex with the AMPA receptor GluA2 agonist binding domain. Here, a methionine (Met729) was highly disordered compared to previous agonist-bound structures. This observation provides a possible explanation for the pharmacological profile. In the structure with 7a, an unusual organization of water molecules around the bioisostere arises compared to previous structures of ligands with other bioisosteres. Aspartate analogue 8 with the hydroxy-1,2,3-triazole moiety directly attached to glycine was unexpectedly able to activate both the glutamate and glycine agonist binding sites of the NMDA receptor. These observations demonstrate novel features that arise when employing a hydroxyl-triazole moiety as bioisostere for the distal carboxylic acid in glutamate receptor agonists.

-	~~Authors: Moellerud~~, S., Temperini, P., Kastrup, J.S.	+	Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.,Sainas S, Temperini P, Farnsworth JC, Yi F, M Oslash Llerud S, Jensen A, Nielsen B, Passoni A, Kastrup JS, Hansen KB, Boschi D, Pickering DS, Clausen RP, Lolli ML J Med Chem. 2019 Apr 3. doi: 10.1021/acs.jmedchem.8b01986. PMID:30943028<ref>PMID:30943028</ref>

-	~~Description: Structure~~ of ~~GluA2 ligand-binding domain (S1S2J) in complex with~~ the ~~agonist (~~S)-2-~~Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	~~[[Category: Temperini, P~~]]	+	<div class="pdbe-citations 6q60" style="background-color:#fffaf0;"></div>
-	[[Category: Kastrup, J.S]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kastrup, J S]]
	[[Category: Moellerud, S]]		[[Category: Moellerud, S]]
		+	[[Category: Temperini, P]]
		+	[[Category: Agonist]]
		+	[[Category: Ampa receptor]]
		+	[[Category: Glua2-s1s2]]
		+	[[Category: Ligand binding domain]]
		+	[[Category: Membrane protein]]

OCA at 05:00, 2 January 2019

OCA — Wed, 02 Jan 2019 05:00:55 GMT

←Older revision		Revision as of 05:00, 2 January 2019
Line 5:		Line 5:
	Authors: Moellerud, S., Temperini, P., Kastrup, J.S.		Authors: Moellerud, S., Temperini, P., Kastrup, J.S.

-	Description: ~~STRUCTURE OF GLUA2 LIGAND~~-~~BINDING DOMAIN~~ (S1S2J) ~~IN COMPLEX WITH THE AGONIST~~ (S) 2-~~AMINO~~-3-(2-~~METHYL~~-5-~~HYDROXY~~-2H-1,2,3-~~TRIAZOL~~-4-YL)~~PROPANOIC ACID AT~~ 1.55 A ~~RESOLUTION~~	+	Description: Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Temperini, P]]		[[Category: Temperini, P]]
	[[Category: Kastrup, J.S]]		[[Category: Kastrup, J.S]]
	[[Category: Moellerud, S]]		[[Category: Moellerud, S]]

OCA at 06:54, 26 December 2018

OCA — Wed, 26 Dec 2018 06:54:07 GMT

←Older revision		Revision as of 06:54, 26 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6q60 is ON HOLD	+	The entry 6q60 is ON HOLD until Paper Publication

	Authors: Moellerud, S., Temperini, P., Kastrup, J.S.		Authors: Moellerud, S., Temperini, P., Kastrup, J.S.

-	Description: ~~Structure of GluA2 ligand~~-~~binding domain~~ (~~S1S2~~) ~~in complex with~~ (S) 2-~~Amino~~-3-(2-~~methyl~~-5-~~hydroxy~~-2H-1,2,3-~~triazol~~-4-yl)~~propanoic acid at~~ 1.55 A ~~resolution~~	+	Description: STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J) IN COMPLEX WITH THE AGONIST (S) 2-AMINO-3-(2-METHYL-5-HYDROXY-2H-1,2,3-TRIAZOL-4-YL)PROPANOIC ACID AT 1.55 A RESOLUTION
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Temperini, P]]
	[[Category: Kastrup, J.S]]		[[Category: Kastrup, J.S]]
	[[Category: Moellerud, S]]		[[Category: Moellerud, S]]
-	[[Category: Temperini, P]]

OCA: Protected "6q60" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2018 06:45:01 GMT

Protected "6q60" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:45, 19 December 2018

OCA: New page: '''Unreleased structure''' The entry 6q60 is ON HOLD Authors: Moellerud, S., Temperini, P., Kastrup, J.S. Description: Structure of GluA2 ligand-binding domain (S1S2) in complex with (...

OCA — Wed, 19 Dec 2018 06:45:00 GMT

New page: '''Unreleased structure''' The entry 6q60 is ON HOLD Authors: Moellerud, S., Temperini, P., Kastrup, J.S. Description: Structure of GluA2 ligand-binding domain (S1S2) in complex with (...

New page

'''Unreleased structure'''

The entry 6q60 is ON HOLD

Authors: Moellerud, S., Temperini, P., Kastrup, J.S.

Description: Structure of GluA2 ligand-binding domain (S1S2) in complex with (S) 2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution
[[Category: Unreleased Structures]]
[[Category: Kastrup, J.S]]
[[Category: Moellerud, S]]
[[Category: Temperini, P]]