6q6p - Revision history

OCA at 11:54, 24 January 2024

OCA — Wed, 24 Jan 2024 11:54:08 GMT

←Older revision		Revision as of 11:54, 24 January 2024
Line 1:		Line 1:

	==Antarctic fish cytoglobin 1 from D.mawsoni==		==Antarctic fish cytoglobin 1 from D.mawsoni==
-	<StructureSection load='6q6p' size='340' side='right'caption='[[6q6p]]' scene=''>	+	<StructureSection load='6q6p' size='340' side='right'caption='[[6q6p]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q6P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6Q6P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q6p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dissostichus_mawsoni Dissostichus mawsoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q6P FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6q6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q6p OCA], [~~http~~://pdbe.org/6q6p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6q6p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6q6p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6q6p ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q6p OCA], [https://pdbe.org/6q6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q6p RCSB], [https://www.ebi.ac.uk/pdbsum/6q6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q6p ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A192X9K5_DISMA A0A192X9K5_DISMA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	While the functions of the recently discovered cytoglobin, ubiquitously expressed in vertebrate tissues, remain uncertain, Antarctic fish provide unparalleled models to study novel protein traits that may arise from cold adaptation. We report here the spectral, ligand-binding and enzymatic properties (peroxynitrite isomerization, nitrite-reductase activity) of cytoglobin-1 from two Antarctic fish, Chaenocephalus aceratus and Dissostichus mawsoni, and present the crystal structure of D. mawsoni cytoglobin-1. The Antarctic cytoglobins-1 display high O2 affinity, scarcely compatible with an O2-supply role, a slow rate constant for nitrite-reductase activity, and do not catalyze peroxynitrite isomerization. Compared with mesophilic orthologues, the cold-adapted cytoglobins favor binding of exogenous ligands to the hexa-coordinated bis-histidyl species, a trait related to their higher rate constant for distal-His/heme-Fe dissociation relative to human cytoglobin. At the light of a remarkable 3D-structure conservation, the observed differences in ligand-binding kinetics may reflect Antarctic fish cytoglobin-1 specific features in the dynamics of the heme distal region and of protein matrix cavities, suggesting adaptation to functional requirements posed by the cold environment. Taken together, the biochemical and biophysical data presented suggest that in Antarctic fish, as in humans, cytoglobin-1 unlikely plays a role in O2 transport, rather it may be involved in processes such as NO detoxification.

-	==~~See Also~~==	+	Structural and functional properties of Antarctic fish cytoglobins-1: Cold-reactivity in multi-ligand reactions.,Giordano D, Pesce A, Vermeylen S, Abbruzzetti S, Nardini M, Marchesani F, Berghmans H, Seira C, Bruno S, Javier Luque F, di Prisco G, Ascenzi P, Dewilde S, Bolognesi M, Viappiani C, Verde C Comput Struct Biotechnol J. 2020 Aug 12;18:2132-2144. doi:, 10.1016/j.csbj.2020.08.007. eCollection 2020. PMID:32913582<ref>PMID:32913582</ref>
-	*[[Cytoglobin\|Cytoglobin]]	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6q6p" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dissostichus mawsoni]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Abbruzzetti S]]		[[Category: Abbruzzetti S]]

OCA at 07:24, 30 September 2020

OCA — Wed, 30 Sep 2020 07:24:39 GMT

←Older revision		Revision as of 07:24, 30 September 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6q6p is ~~ON HOLD~~	+	==Antarctic fish cytoglobin 1 from D.mawsoni==
		+	<StructureSection load='6q6p' size='340' side='right'caption='[[6q6p]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q6P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Q6P FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6q6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q6p OCA], [http://pdbe.org/6q6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q6p RCSB], [http://www.ebi.ac.uk/pdbsum/6q6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q6p ProSAT]</span></td></tr>
		+	</table>

-	Authors: Giordano, D., Pesce, A., Vermeylen, S., Abbruzzetti, S., Nardini, M., Marchesani, F., Berghmans, H., Seira, C., Bruno, S., Luque, F.J., di Prisco, G., Ascenzi, P., Dewilde, S., Bolognesi, M., Viappiani, C., Verde, C.	+	==See Also==
-		+	*[[Cytoglobin\|Cytoglobin]]
-	~~Description: Antarctic fish cytoglobin 1 from D.mawsoni~~	+	__TOC__
-	[[Category: ~~Unreleased~~ Structures]]	+	</StructureSection>
-	[[Category: ~~Seira, C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pesce, A~~]]	+	[[Category: Abbruzzetti S]]
-	[[Category: ~~Nardini, M~~]]	+	[[Category: Ascenzi P]]
-	[[Category: ~~Vermeylen, S~~]]	+	[[Category: Berghmans H]]
-	[[Category: Bruno, S]]	+	[[Category: Bolognesi M]]
-	[[Category: ~~Giordano, D~~]]	+	[[Category: Bruno S]]
-	[[Category: ~~Dewilde, S~~]]	+	[[Category: Dewilde S]]
-	[[Category: ~~Ascenzi, P~~]]	+	[[Category: Giordano D]]
-	[[Category: ~~Viappiani, C~~]]	+	[[Category: Luque FJ]]
-	[[Category: ~~Di Prisco, G~~]]	+	[[Category: Marchesani F]]
-	[[Category: ~~Marchesani, F~~]]	+	[[Category: Nardini M]]
-	[[Category: ~~Luque, F.J~~]]	+	[[Category: Pesce A]]
-	[[Category: ~~Berghmans, H~~]]	+	[[Category: Seira C]]
-	[[Category: ~~Bolognesi, M~~]]	+	[[Category: Verde C]]
-	[[Category: ~~Abbruzzetti, S~~]]	+	[[Category: Vermeylen S]]
-	[[Category: ~~Verde, C~~]]	+	[[Category: Viappiani C]]
		+	[[Category: Di Prisco G]]

OCA: Protected "6q6p" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2018 06:47:17 GMT

Protected "6q6p" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:47, 19 December 2018

OCA: New page: '''Unreleased structure''' The entry 6q6p is ON HOLD Authors: Giordano, D., Pesce, A., Vermeylen, S., Abbruzzetti, S., Nardini, M., Marchesani, F., Berghmans, H., Seira, C., Bruno, S., ...

OCA — Wed, 19 Dec 2018 06:47:15 GMT

New page: '''Unreleased structure''' The entry 6q6p is ON HOLD Authors: Giordano, D., Pesce, A., Vermeylen, S., Abbruzzetti, S., Nardini, M., Marchesani, F., Berghmans, H., Seira, C., Bruno, S., ...

New page

'''Unreleased structure'''

The entry 6q6p is ON HOLD

Authors: Giordano, D., Pesce, A., Vermeylen, S., Abbruzzetti, S., Nardini, M., Marchesani, F., Berghmans, H., Seira, C., Bruno, S., Luque, F.J., di Prisco, G., Ascenzi, P., Dewilde, S., Bolognesi, M., Viappiani, C., Verde, C.

Description: Antarctic fish cytoglobin 1 from D.mawsoni
[[Category: Unreleased Structures]]
[[Category: Seira, C]]
[[Category: Pesce, A]]
[[Category: Nardini, M]]
[[Category: Vermeylen, S]]
[[Category: Bruno, S]]
[[Category: Giordano, D]]
[[Category: Dewilde, S]]
[[Category: Ascenzi, P]]
[[Category: Viappiani, C]]
[[Category: Di Prisco, G]]
[[Category: Marchesani, F]]
[[Category: Luque, F.J]]
[[Category: Berghmans, H]]
[[Category: Bolognesi, M]]
[[Category: Abbruzzetti, S]]
[[Category: Verde, C]]