6q79 - Revision history

OCA at 09:24, 1 May 2019

OCA — Wed, 01 May 2019 09:24:35 GMT

←Older revision		Revision as of 09:24, 1 May 2019
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	<StructureSection load='6q79' size='340' side='right'caption='[[6q79]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='6q79' size='340' side='right'caption='[[6q79]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q79]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q79 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q79]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q79 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZDC:3,7-ANHYDRO-2,8-DIDEOXY-L-GLYCERO-D-GLUCO-OCTONIC+ACID'>ZDC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZDC:3,7-ANHYDRO-2,8-DIDEOXY-L-GLYCERO-D-GLUCO-OCTONIC+ACID'>ZDC</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DLY:D-LYSINE'>DLY</scene>, <scene name='pdbligand=DTY:D-TYROSINE'>DTY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DLY:D-LYSINE'>DLY</scene>, <scene name='pdbligand=DTY:D-TYROSINE'>DTY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6q6w\|6q6w]], [[6q6x\|6q6x]], [[6q77\|6q77]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6q6w\|6q6w]], [[6q6x\|6q6x]], [[6q77\|6q77]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lecB, C0043_24310, C0044_25260, C0046_23510, CAZ10_21840, CW299_25270, DI492_13230, DT376_00595, PAERUG_E15_London_28_01_14_00983, PAMH19_1713, RW109_RW109_02453 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q79 OCA], [http://pdbe.org/6q79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q79 RCSB], [http://www.ebi.ac.uk/pdbsum/6q79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q79 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q79 OCA], [http://pdbe.org/6q79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q79 RCSB], [http://www.ebi.ac.uk/pdbsum/6q79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q79 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:07, 20 March 2019

OCA — Wed, 20 Mar 2019 08:07:55 GMT

←Older revision		Revision as of 08:07, 20 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6q79 is ~~ON HOLD until Paper~~ Publication	+	==Structure of Fucosylated D-antimicrobial peptide SB4 in complex with the Fucose-binding lectin PA-IIL at 2.009 Angstrom resolution==
		+	<StructureSection load='6q79' size='340' side='right'caption='[[6q79]], [[Resolution\|resolution]] 2.01Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6q79]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q79 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZDC:3,7-ANHYDRO-2,8-DIDEOXY-L-GLYCERO-D-GLUCO-OCTONIC+ACID'>ZDC</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DLY:D-LYSINE'>DLY</scene>, <scene name='pdbligand=DTY:D-TYROSINE'>DTY</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6q6w\|6q6w]], [[6q6x\|6q6x]], [[6q77\|6q77]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q79 OCA], [http://pdbe.org/6q79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q79 RCSB], [http://www.ebi.ac.uk/pdbsum/6q79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q79 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Herein, we report X-ray crystal structures of 11-13 residue antimicrobial peptides (AMPs) active against Pseudomonas aeruginosa as complexes of fucosylated d-enantiomeric sequences with the P. aeruginosa lectin LecB. These represent the first crystal structures of short AMPs. In 24 individual structures of eight different peptides, we found mostly alpha-helices assembled as two-helix or four-helix bundles with a hydrophobic core and cationic residues pointing outside. Two of the analogs formed an extended structure engaging in multiple contacts with the lectin. Molecular dynamics (MD) simulations showed that alpha-helices are stabilized by bundle formation and suggested that the N-terminal acyl group present in the linker to the fucosyl group can extend the helix by one additional H-bond and increase alpha-helix amphiphilicity. Investigating N-terminal acylation led to AMPs with equivalent and partly stronger antibacterial effects compared to the free peptide.

-	~~Authors:~~ Baeriswyl, S., Stocker, A., ~~Reymond~~, J.-L.	+	X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes.,Baeriswyl S, Gan BH, Siriwardena TN, Visini R, Robadey M, Javor S, Stocker A, Darbre T, Reymond JL ACS Chem Biol. 2019 Mar 11. doi: 10.1021/acschembio.9b00047. PMID:30830745<ref>PMID:30830745</ref>

-	~~Description: Structure~~ of ~~Fucosylated D-antimicrobial peptide SB4 in complex with~~ the ~~Fucose-binding lectin PA-IIL at 2~~.~~009 Angstrom resolution~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Reymond, J.-L~~]]	+	<div class="pdbe-citations 6q79" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Baeriswyl, S]]		[[Category: Baeriswyl, S]]
		+	[[Category: Reymond, J L]]
	[[Category: Stocker, A]]		[[Category: Stocker, A]]
		+	[[Category: Antibiotic]]
		+	[[Category: Antimicrobial]]
		+	[[Category: Complex]]
		+	[[Category: Lectin]]

OCA at 06:54, 26 December 2018

OCA — Wed, 26 Dec 2018 06:54:44 GMT

←Older revision		Revision as of 06:54, 26 December 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6q79 is ON HOLD	+	The entry 6q79 is ON HOLD until Paper Publication

	Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L.		Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L.

OCA: Protected "6q79" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2018 06:49:15 GMT

Protected "6q79" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:49, 19 December 2018

OCA: New page: '''Unreleased structure''' The entry 6q79 is ON HOLD Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L. Description: Structure of Fucosylated D-antimicrobial peptide SB4 in complex wi...

OCA — Wed, 19 Dec 2018 06:49:14 GMT

New page: '''Unreleased structure''' The entry 6q79 is ON HOLD Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L. Description: Structure of Fucosylated D-antimicrobial peptide SB4 in complex wi...

New page

'''Unreleased structure'''

The entry 6q79 is ON HOLD

Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L.

Description: Structure of Fucosylated D-antimicrobial peptide SB4 in complex with the Fucose-binding lectin PA-IIL at 2.009 Angstrom resolution
[[Category: Unreleased Structures]]
[[Category: Reymond, J.-L]]
[[Category: Baeriswyl, S]]
[[Category: Stocker, A]]