6q8f - Revision history

OCA at 06:21, 12 June 2019

OCA — Wed, 12 Jun 2019 06:21:24 GMT

←Older revision		Revision as of 06:21, 12 June 2019
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	<StructureSection load='6q8f' size='340' side='right'caption='[[6q8f]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6q8f' size='340' side='right'caption='[[6q8f]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q8f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q8F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q8F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMU1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q8f OCA], [http://pdbe.org/6q8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q8f RCSB], [http://www.ebi.ac.uk/pdbsum/6q8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q8f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q8f OCA], [http://pdbe.org/6q8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q8f RCSB], [http://www.ebi.ac.uk/pdbsum/6q8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q8f ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ashraf, U]]		[[Category: Ashraf, U]]

OCA at 06:58, 23 May 2019

OCA — Thu, 23 May 2019 06:58:02 GMT

←Older revision		Revision as of 06:58, 23 May 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6q8f is ~~ON HOLD until Dec 14 2020~~	+	==Nterminal domain of human SMU1==
		+	<StructureSection load='6q8f' size='340' side='right'caption='[[6q8f]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6q8f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q8F FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q8f OCA], [http://pdbe.org/6q8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q8f RCSB], [http://www.ebi.ac.uk/pdbsum/6q8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q8f ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	New therapeutic strategies targeting influenza are actively sought due to limitations in current drugs available. Host-directed therapy is an emerging concept to target host functions involved in pathogen life cycles and/or pathogenesis, rather than pathogen components themselves. From this perspective, we focused on an essential host partner of influenza viruses, the RED-SMU1 splicing complex. Here, we identified two synthetic molecules targeting an alpha-helix/groove interface essential for RED-SMU1 complex assembly. We solved the structure of the SMU1 N-terminal domain in complex with RED or bound to one of the molecules identified to disrupt this complex. We show that these compounds inhibiting RED-SMU1 interaction also decrease endogenous RED-SMU1 levels and inhibit viral mRNA splicing and viral multiplication, while preserving cell viability. Overall, our data demonstrate the potential of RED-SMU1 destabilizing molecules as an antiviral therapy that could be active against a wide range of influenza viruses and be less prone to drug resistance.

-	~~Authors:~~ Tengo, L., Le Corre, L., Fournier, G~~., Ashraf, U.~~, Busca, P., Rameix-Welti~~, M.-A.~~, Gravier-Pelletier, C., Ruigrok~~, R.W.H.~~, Jacob, Y., Vidalain~~, P.-O.~~, Pietrancosta, N., Naffakh, N~~., McCarthy,~~ A.A., ~~Crepin, T~~.	+	Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.,Ashraf U, Tengo L, Le Corre L, Fournier G, Busca P, McCarthy AA, Rameix-Welti MA, Gravier-Pelletier C, Ruigrok RWH, Jacob Y, Vidalain PO, Pietrancosta N, Crepin T, Naffakh N Proc Natl Acad Sci U S A. 2019 May 10. pii: 1901214116. doi:, 10.1073/pnas.1901214116. PMID:31076555<ref>PMID:31076555</ref>

-	~~Description: Nterminal domain~~ of ~~human SMU1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Tengo, L]]~~	+	<div class="pdbe-citations 6q8f" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Vidalain, P.-O~~]]	+	== References ==
-	[[Category: ~~Rameix-Welti~~, ~~M.-A~~]]	+	<references/>
-	[[Category: ~~Jacob~~, Y]]	+	__TOC__
-	[[Category: ~~Gravier-Pelletier~~, C]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ashraf, U]]
		+	[[Category: Busca, P]]
		+	[[Category: Corre, L Le]]
	[[Category: Crepin, T]]		[[Category: Crepin, T]]
	[[Category: Fournier, G]]		[[Category: Fournier, G]]
-	[[Category: ~~Ruigrok~~, ~~R.W.H~~]]	+	[[Category: Gravier-Pelletier, C]]
-	[[Category: ~~Busca~~, P]]	+	[[Category: Jacob, Y]]
		+	[[Category: McCarthy, A A]]
	[[Category: Naffakh, N]]		[[Category: Naffakh, N]]
-	[[Category: Ashraf, U]]
	[[Category: Pietrancosta, N]]		[[Category: Pietrancosta, N]]
-	[[Category: ~~Le Corre~~, L]]	+	[[Category: Rameix-Welti, M A]]
-	[[Category: ~~Mccarthy~~, A.A]]	+	[[Category: Ruigrok, R W.H]]
		+	[[Category: Tengo, L]]
		+	[[Category: Vidalain, P O]]
		+	[[Category: Splicing]]
		+	[[Category: Splicing factor]]

OCA: Protected "6q8f" [edit=sysop:move=sysop]

OCA — Wed, 26 Dec 2018 06:56:44 GMT

Protected "6q8f" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:56, 26 December 2018

OCA: New page: '''Unreleased structure''' The entry 6q8f is ON HOLD until Dec 14 2020 Authors: Tengo, L., Le Corre, L., Fournier, G., Ashraf, U., Busca, P., Rameix-Welti, M.-A., Gravier-Pelletier, C.,...

OCA — Wed, 26 Dec 2018 06:56:43 GMT

New page: '''Unreleased structure''' The entry 6q8f is ON HOLD until Dec 14 2020 Authors: Tengo, L., Le Corre, L., Fournier, G., Ashraf, U., Busca, P., Rameix-Welti, M.-A., Gravier-Pelletier, C.,...

New page

'''Unreleased structure'''

The entry 6q8f is ON HOLD until Dec 14 2020

Authors: Tengo, L., Le Corre, L., Fournier, G., Ashraf, U., Busca, P., Rameix-Welti, M.-A., Gravier-Pelletier, C., Ruigrok, R.W.H., Jacob, Y., Vidalain, P.-O., Pietrancosta, N., Naffakh, N., McCarthy, A.A., Crepin, T.

Description: Nterminal domain of human SMU1
[[Category: Unreleased Structures]]
[[Category: Tengo, L]]
[[Category: Vidalain, P.-O]]
[[Category: Rameix-Welti, M.-A]]
[[Category: Jacob, Y]]
[[Category: Gravier-Pelletier, C]]
[[Category: Crepin, T]]
[[Category: Fournier, G]]
[[Category: Ruigrok, R.W.H]]
[[Category: Busca, P]]
[[Category: Naffakh, N]]
[[Category: Ashraf, U]]
[[Category: Pietrancosta, N]]
[[Category: Le Corre, L]]
[[Category: Mccarthy, A.A]]