OCA at 11:55, 24 January 2024

OCA — Wed, 24 Jan 2024 11:55:52 GMT

←Older revision		Revision as of 11:55, 24 January 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 6q8z is ~~ON HOLD~~	+	==Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide==
		+	<StructureSection load='6q8z' size='340' side='right'caption='[[6q8z]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6q8z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q8Z FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=HFK:2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1-cyclohexane]-5-one'>HFK</scene>, <scene name='pdbligand=HR5:~{N}-(cyclobutylmethyl)-1,5-dimethyl-pyrazole-4-carboxamide'>HR5</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q8z OCA], [https://pdbe.org/6q8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q8z RCSB], [https://www.ebi.ac.uk/pdbsum/6q8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q8z ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN] Defects in GALK1 are the cause of galactosemia II (GALCT2) [MIM:[https://omim.org/entry/230200 230200]. Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.<ref>PMID:10521295</ref> <ref>PMID:10790206</ref> <ref>PMID:11231902</ref> <ref>PMID:11139256</ref> <ref>PMID:12694189</ref> <ref>PMID:15024738</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN] Major enzyme for galactose metabolism.

-	~~Authors: Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.~~	+	==See Also==
-		+	*[[Galactokinase\|Galactokinase]]
-	~~Description: Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Foster, W~~]]	+	__TOC__
-	[[Category: ~~Brandao-Neto, J~~]]	+	</StructureSection>
-	[[Category: ~~Lai, K~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Bezerra, G.A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Yue, W.W~~]]	+	[[Category: Arrowsmith C]]
-	[[Category: ~~Arrowsmith, C~~]]	+	[[Category: Bezerra GA]]
-	[[Category: ~~Zhang, M~~]]	+	[[Category: Bountra C]]
-	[[Category: Edwards, A]]	+	[[Category: Brandao-Neto J]]
-	[[Category: ~~Douangamath, A~~]]	+	[[Category: Brennan P]]
-	[[Category: ~~Mackinnon, S.R~~]]	+	[[Category: Douangamath A]]
-	[[Category: ~~Krojer, T~~]]	+	[[Category: Edwards A]]
-	[[Category: ~~Brennan, P~~]]	+	[[Category: Foster W]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Krojer T]]
		+	[[Category: Lai K]]
		+	[[Category: Mackinnon SR]]
		+	[[Category: Yue WW]]
		+	[[Category: Zhang M]]

OCA: Protected "6q8z" [edit=sysop:move=sysop]

OCA — Wed, 26 Dec 2018 06:59:00 GMT

Protected "6q8z" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:59, 26 December 2018

OCA: New page: '''Unreleased structure''' The entry 6q8z is ON HOLD Authors: Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwar...

OCA — Wed, 26 Dec 2018 06:58:58 GMT

New page: '''Unreleased structure''' The entry 6q8z is ON HOLD Authors: Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwar...

New page

'''Unreleased structure'''

The entry 6q8z is ON HOLD

Authors: Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.

Description: Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide
[[Category: Unreleased Structures]]
[[Category: Foster, W]]
[[Category: Brandao-Neto, J]]
[[Category: Lai, K]]
[[Category: Bezerra, G.A]]
[[Category: Yue, W.W]]
[[Category: Arrowsmith, C]]
[[Category: Zhang, M]]
[[Category: Edwards, A]]
[[Category: Douangamath, A]]
[[Category: Mackinnon, S.R]]
[[Category: Krojer, T]]
[[Category: Brennan, P]]
[[Category: Bountra, C]]

6q8z - Revision history

OCA at 11:55, 24 January 2024

OCA: Protected "6q8z" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6q8z is ON HOLD Authors: Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwar...