6qdj - Revision history

OCA at 11:58, 24 January 2024

OCA — Wed, 24 Jan 2024 11:58:13 GMT

←Older revision		Revision as of 11:58, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6qdj' size='340' side='right'caption='[[6qdj]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='6qdj' size='340' side='right'caption='[[6qdj]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qdj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QDJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QDJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qdj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QDJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.884Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qdj OCA], [~~http~~://pdbe.org/6qdj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qdj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qdj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qdj ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qdj OCA], [https://pdbe.org/6qdj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qdj RCSB], [https://www.ebi.ac.uk/pdbsum/6qdj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qdj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MYO4_CAEEL MYO4_CAEEL]] Required for muscle contraction.<ref>PMID:27123983</ref>	+	[https://www.uniprot.org/uniprot/MYO4_CAEEL MYO4_CAEEL] Required for muscle contraction.<ref>PMID:27123983</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6qdj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6qdj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Caenorhabditis elegans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arnese, R]]	+	[[Category: Arnese R]]
-	[[Category: Clausen, T]]	+	[[Category: Clausen T]]
-	[[Category: Meinhart, A]]	+	[[Category: Meinhart A]]
-	~~[[Category: Mhc-b]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Myosin]]~~	+
-	~~[[Category: Unc-54~~]]	+

OCA at 09:07, 30 October 2019

OCA — Wed, 30 Oct 2019 09:07:48 GMT

←Older revision		Revision as of 09:07, 30 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qdj is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin==
		+	<StructureSection load='6qdj' size='340' side='right'caption='[[6qdj]], [[Resolution\|resolution]] 1.88Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qdj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QDJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qdj OCA], [http://pdbe.org/6qdj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qdj RCSB], [http://www.ebi.ac.uk/pdbsum/6qdj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qdj ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYO4_CAEEL MYO4_CAEEL]] Required for muscle contraction.<ref>PMID:27123983</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Myosin is a motor protein that is essential for a variety of processes ranging from intracellular transport to muscle contraction. Folding and assembly of myosin relies on a specific chaperone, UNC-45. To address its substrate-targeting mechanism, we reconstitute the interplay between Caenorhabditis elegans UNC-45 and muscle myosin MHC-B in insect cells. In addition to providing a cellular chaperone assay, the established system enabled us to produce large amounts of functional muscle myosin, as evidenced by a biochemical and structural characterization, and to directly monitor substrate binding to UNC-45. Data from in vitro and cellular chaperone assays, together with crystal structures of binding-deficient UNC-45 mutants, highlight the importance of utilizing a flexible myosin-binding domain. This so-called UCS domain can adopt discrete conformations to efficiently bind and fold substrate. Moreover, our data uncover the molecular basis of temperature-sensitive UNC-45 mutations underlying one of the most prominent motility defects in C. elegans.

-	~~Authors: Meinhart, A~~., ~~Clausen~~, T., Arnese, R.	+	Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.,Hellerschmied D, Lehner A, Franicevic N, Arnese R, Johnson C, Vogel A, Meinhart A, Kurzbauer R, Deszcz L, Gazda L, Geeves M, Clausen T Nat Commun. 2019 Oct 21;10(1):4781. doi: 10.1038/s41467-019-12667-8. PMID:31636255<ref>PMID:31636255</ref>

-	~~Description: Molecular features~~ of the ~~UNC~~-~~45 chaperone critical for binding and folding muscle myosin~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6qdj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arnese, R]]
	[[Category: Clausen, T]]		[[Category: Clausen, T]]
	[[Category: Meinhart, A]]		[[Category: Meinhart, A]]
-	[[Category: ~~Arnese, R~~]]	+	[[Category: Mhc-b]]
		+	[[Category: Motor protein]]
		+	[[Category: Myosin]]
		+	[[Category: Unc-54]]

OCA at 07:55, 13 February 2019

OCA — Wed, 13 Feb 2019 07:55:25 GMT

←Older revision		Revision as of 07:55, 13 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qdj is ON HOLD	+	The entry 6qdj is ON HOLD until Paper Publication

	Authors: Meinhart, A., Clausen, T., Arnese, R.		Authors: Meinhart, A., Clausen, T., Arnese, R.

OCA: Protected "6qdj" [edit=sysop:move=sysop]

OCA — Wed, 09 Jan 2019 05:11:14 GMT

Protected "6qdj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:11, 9 January 2019

OCA: New page: '''Unreleased structure''' The entry 6qdj is ON HOLD Authors: Meinhart, A., Clausen, T., Arnese, R. Description: Molecular features of the UNC-45 chaperone critical for binding and fol...

OCA — Wed, 09 Jan 2019 05:11:13 GMT

New page: '''Unreleased structure''' The entry 6qdj is ON HOLD Authors: Meinhart, A., Clausen, T., Arnese, R. Description: Molecular features of the UNC-45 chaperone critical for binding and fol...

New page

'''Unreleased structure'''

The entry 6qdj is ON HOLD

Authors: Meinhart, A., Clausen, T., Arnese, R.

Description: Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
[[Category: Unreleased Structures]]
[[Category: Clausen, T]]
[[Category: Meinhart, A]]
[[Category: Arnese, R]]