6qdm - Revision history

OCA at 11:58, 24 January 2024

OCA — Wed, 24 Jan 2024 11:58:15 GMT

←Older revision		Revision as of 11:58, 24 January 2024
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	<StructureSection load='6qdm' size='340' side='right'caption='[[6qdm]], [[Resolution\|resolution]] 3.80Å' scene=''>		<StructureSection load='6qdm' size='340' side='right'caption='[[6qdm]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qdm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QDM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QDM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qdm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QDM FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.8Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qdk\|6qdk]]~~, [[~~6qdl~~\|~~6qdl~~]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qdm OCA], [https://pdbe.org/6qdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qdm RCSB], [https://www.ebi.ac.uk/pdbsum/6qdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qdm ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qdm OCA], [~~http~~://pdbe.org/6qdm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qdm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qdm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qdm ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G5EG62_CAEEL G5EG62_CAEEL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Caenorhabditis elegans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Clausen, T]]	+	[[Category: Clausen T]]
-	[[Category: Hellerschmied, D]]	+	[[Category: Hellerschmied D]]
-	[[Category: Meinhart, A]]	+	[[Category: Meinhart A]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Myofilament formation]]~~	+
-	~~[[Category: Myosin folding]]~~	+
-	~~[[Category: Protein filament~~]]	+

OCA at 09:08, 30 October 2019

OCA — Wed, 30 Oct 2019 09:08:07 GMT

←Older revision		Revision as of 09:08, 30 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qdm is ~~ON HOLD until Paper~~ Publication	+	==Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin==
		+	<StructureSection load='6qdm' size='340' side='right'caption='[[6qdm]], [[Resolution\|resolution]] 3.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qdm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QDM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QDM FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qdk\|6qdk]], [[6qdl\|6qdl]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qdm OCA], [http://pdbe.org/6qdm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qdm RCSB], [http://www.ebi.ac.uk/pdbsum/6qdm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qdm ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Myosin is a motor protein that is essential for a variety of processes ranging from intracellular transport to muscle contraction. Folding and assembly of myosin relies on a specific chaperone, UNC-45. To address its substrate-targeting mechanism, we reconstitute the interplay between Caenorhabditis elegans UNC-45 and muscle myosin MHC-B in insect cells. In addition to providing a cellular chaperone assay, the established system enabled us to produce large amounts of functional muscle myosin, as evidenced by a biochemical and structural characterization, and to directly monitor substrate binding to UNC-45. Data from in vitro and cellular chaperone assays, together with crystal structures of binding-deficient UNC-45 mutants, highlight the importance of utilizing a flexible myosin-binding domain. This so-called UCS domain can adopt discrete conformations to efficiently bind and fold substrate. Moreover, our data uncover the molecular basis of temperature-sensitive UNC-45 mutations underlying one of the most prominent motility defects in C. elegans.

-	~~Authors: Meinhart~~, A., ~~Clausen~~, T., ~~Hellerschmied~~, D.	+	Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.,Hellerschmied D, Lehner A, Franicevic N, Arnese R, Johnson C, Vogel A, Meinhart A, Kurzbauer R, Deszcz L, Gazda L, Geeves M, Clausen T Nat Commun. 2019 Oct 21;10(1):4781. doi: 10.1038/s41467-019-12667-8. PMID:31636255<ref>PMID:31636255</ref>

-	~~Description: Molecular features~~ of the ~~UNC~~-~~45 chaperone critical for binding and folding muscle myosin~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6qdm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Clausen, T]]		[[Category: Clausen, T]]
	[[Category: Hellerschmied, D]]		[[Category: Hellerschmied, D]]
	[[Category: Meinhart, A]]		[[Category: Meinhart, A]]
		+	[[Category: Chaperone]]
		+	[[Category: Myofilament formation]]
		+	[[Category: Myosin folding]]
		+	[[Category: Protein filament]]

OCA at 07:55, 13 February 2019

OCA — Wed, 13 Feb 2019 07:55:43 GMT

←Older revision		Revision as of 07:55, 13 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qdm is ON HOLD	+	The entry 6qdm is ON HOLD until Paper Publication

	Authors: Meinhart, A., Clausen, T., Hellerschmied, D.		Authors: Meinhart, A., Clausen, T., Hellerschmied, D.

OCA: Protected "6qdm" [edit=sysop:move=sysop]

OCA — Wed, 09 Jan 2019 05:11:29 GMT

Protected "6qdm" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:11, 9 January 2019

OCA: New page: '''Unreleased structure''' The entry 6qdm is ON HOLD Authors: Meinhart, A., Clausen, T., Hellerschmied, D. Description: Molecular features of the UNC-45 chaperone critical for binding ...

OCA — Wed, 09 Jan 2019 05:11:28 GMT

New page: '''Unreleased structure''' The entry 6qdm is ON HOLD Authors: Meinhart, A., Clausen, T., Hellerschmied, D. Description: Molecular features of the UNC-45 chaperone critical for binding ...

New page

'''Unreleased structure'''

The entry 6qdm is ON HOLD

Authors: Meinhart, A., Clausen, T., Hellerschmied, D.

Description: Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
[[Category: Unreleased Structures]]
[[Category: Clausen, T]]
[[Category: Hellerschmied, D]]
[[Category: Meinhart, A]]