6qiz - Revision history

OCA at 12:01, 24 January 2024

OCA — Wed, 24 Jan 2024 12:01:55 GMT

←Older revision		Revision as of 12:01, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6qiz' size='340' side='right'caption='[[6qiz]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6qiz' size='340' side='right'caption='[[6qiz]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qiz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QIZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qiz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qiz OCA], [~~http~~://pdbe.org/6qiz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qiz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qiz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qiz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qiz OCA], [https://pdbe.org/6qiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qiz RCSB], [https://www.ebi.ac.uk/pdbsum/6qiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qiz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ICI2_HORVU ICI2_HORVU]] Inhibits both subtilisin and chymotrypsin.	+	[https://www.uniprot.org/uniprot/ICI2_HORVU ICI2_HORVU] Inhibits both subtilisin and chymotrypsin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6qiz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6qiz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Chymotrypsin inhibitor 3D structures\|Chymotrypsin inhibitor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hordeum vulgare]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Romero, A]]	+	[[Category: Romero A]]
-	[[Category: Ruiz~~, F M]]~~	+	[[Category: Ruiz FM]]
-	~~[[Category: Chymotrypsin inhibitor 2]]~~	+
-	~~[[Category: Hydrolase inhibitor]]~~	+
-	~~[[Category: Plant protein~~]]	+

OCA at 09:14, 25 December 2019

OCA — Wed, 25 Dec 2019 09:14:56 GMT

←Older revision		Revision as of 09:14, 25 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qiz is ~~ON HOLD until Paper~~ Publication	+	==CI-2, conformation 2==
		+	<StructureSection load='6qiz' size='340' side='right'caption='[[6qiz]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qiz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QIZ FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qiz OCA], [http://pdbe.org/6qiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qiz RCSB], [http://www.ebi.ac.uk/pdbsum/6qiz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qiz ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ICI2_HORVU ICI2_HORVU]] Inhibits both subtilisin and chymotrypsin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The macromolecular machines of life use allosteric control to self-assemble, dissociate and change shape in response to signals. Despite enormous interest, the design of nanoscale allosteric assemblies has proven tremendously challenging. Here we present a proof of concept of allosteric assembly in which an engineered fold switch on the protein monomer triggers or blocks assembly. Our design is based on the hyper-stable, naturally monomeric protein CI2, a paradigm of simple two-state folding, and the toroidal arrangement with 6-fold symmetry that it only adopts in crystalline form. We engineer CI2 to enable a switch between the native and an alternate, latent fold that self-assembles onto hexagonal toroidal particles by exposing a favorable inter-monomer interface. The assembly is controlled on demand via the competing effects of temperature and a designed short peptide. These findings unveil a remarkable potential for structural metamorphosis in proteins and demonstrate key principles for engineering protein-based nanomachinery.

-	~~Authors: Romero, A~~., Ruiz, F.M.	+	Engineering protein assemblies with allosteric control via monomer fold-switching.,Campos LA, Sharma R, Alvira S, Ruiz FM, Ibarra-Molero B, Sadqi M, Alfonso C, Rivas G, Sanchez-Ruiz JM, Romero Garrido A, Valpuesta JM, Munoz V Nat Commun. 2019 Dec 13;10(1):5703. doi: 10.1038/s41467-019-13686-1. PMID:31836707<ref>PMID:31836707</ref>

-	~~Description: CI-2~~, ~~conformation 2~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6qiz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Romero, A]]		[[Category: Romero, A]]
-	[[Category: Ruiz, F.M]]	+	[[Category: Ruiz, F M]]
		+	[[Category: Chymotrypsin inhibitor 2]]
		+	[[Category: Hydrolase inhibitor]]
		+	[[Category: Plant protein]]

OCA: Protected "6qiz" [edit=sysop:move=sysop]

OCA — Wed, 30 Jan 2019 07:01:58 GMT

Protected "6qiz" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:01, 30 January 2019

OCA: New page: '''Unreleased structure''' The entry 6qiz is ON HOLD until Paper Publication Authors: Romero, A., Ruiz, F.M. Description: CI-2, conformation 2 Category: Unreleased Structures [[Cat...

OCA — Wed, 30 Jan 2019 07:01:57 GMT

New page: '''Unreleased structure''' The entry 6qiz is ON HOLD until Paper Publication Authors: Romero, A., Ruiz, F.M. Description: CI-2, conformation 2 Category: Unreleased Structures [[Cat...

New page

'''Unreleased structure'''

The entry 6qiz is ON HOLD until Paper Publication

Authors: Romero, A., Ruiz, F.M.

Description: CI-2, conformation 2
[[Category: Unreleased Structures]]
[[Category: Romero, A]]
[[Category: Ruiz, F.M]]