6qkg - Revision history

OCA at 12:02, 24 January 2024

OCA — Wed, 24 Jan 2024 12:02:47 GMT

←Older revision		Revision as of 12:02, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6qkg' size='340' side='right'caption='[[6qkg]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6qkg' size='340' side='right'caption='[[6qkg]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qkg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacterium_enrichment_culture_clone_n47~~ Bacterium enrichment culture clone ~~n47~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QKG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qkg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacterium_enrichment_culture_clone_N47 Bacterium enrichment culture clone N47]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QKG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qkg OCA], [~~http~~://pdbe.org/6qkg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qkg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qkg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qkg ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qkg OCA], [https://pdbe.org/6qkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qkg RCSB], [https://www.ebi.ac.uk/pdbsum/6qkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qkg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/E1YD54_9DELT E1YD54_9DELT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacterium enrichment culture clone ~~n47~~]]	+	[[Category: Bacterium enrichment culture clone N47]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ermler, U]]	+	[[Category: Ermler U]]
-	[[Category: Kayastha, K]]	+	[[Category: Kayastha K]]
-	~~[[Category: 2-naphthoyl-coa]]~~	+
-	~~[[Category: 2-naphthoyl-coa reductase]]~~	+
-	~~[[Category: 4fe-4]]~~	+
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Fmn]]~~	+
-	~~[[Category: Hydride transfer]]~~	+
-	~~[[Category: Naphthalene]]~~	+
-	~~[[Category: Reductase~~]]	+

OCA at 07:38, 21 May 2019

OCA — Tue, 21 May 2019 07:38:25 GMT

←Older revision		Revision as of 07:38, 21 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qkg is ~~ON HOLD until Paper~~ Publication	+	==2-Naphthoyl-CoA Reductase(NCR)==
		+	<StructureSection load='6qkg' size='340' side='right'caption='[[6qkg]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacterium_enrichment_culture_clone_n47 Bacterium enrichment culture clone n47]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QKG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qkg OCA], [http://pdbe.org/6qkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qkg RCSB], [http://www.ebi.ac.uk/pdbsum/6qkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qkg ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hydride transfers play a crucial role in a multitude of biological redox reactions and are mediated by flavin, deazaflavin or nicotinamide adenine dinucleotide cofactors at standard redox potentials ranging from 0 to -340 mV. 2-Naphthoyl-CoA reductase, a key enzyme of oxygen-independent bacterial naphthalene degradation, uses a low-potential one-electron donor for the two-electron dearomatization of its substrate below the redox limit of known biological hydride transfer processes at E degrees ' = -493 mV. Here we demonstrate by X-ray structural analyses, QM/MM computational studies, and multiple spectroscopy/activity based titrations that highly cooperative electron transfer (n = 3) from a low-potential one-electron (FAD) to a two-electron (FMN) transferring flavin cofactor is the key to overcome the resonance stabilized aromatic system by hydride transfer in a highly hydrophobic pocket. The results evidence how the protein environment inversely functionalizes two flavins to switch from low-potential one-electron to hydride transfer at the thermodynamic limit of flavin redox chemistry.

-	~~Authors~~:	+	Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors.,Willistein M, Bechtel DF, Muller CS, Demmer U, Heimann L, Kayastha K, Schunemann V, Pierik AJ, Ullmann GM, Ermler U, Boll M Nat Commun. 2019 May 6;10(1):2074. doi: 10.1038/s41467-019-10078-3. PMID:31061390<ref>PMID:31061390</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6qkg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bacterium enrichment culture clone n47]]
		+	[[Category: Large Structures]]
		+	[[Category: Ermler, U]]
		+	[[Category: Kayastha, K]]
		+	[[Category: 2-naphthoyl-coa]]
		+	[[Category: 2-naphthoyl-coa reductase]]
		+	[[Category: 4fe-4]]
		+	[[Category: Fad]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Fmn]]
		+	[[Category: Hydride transfer]]
		+	[[Category: Naphthalene]]
		+	[[Category: Reductase]]

OCA at 13:52, 27 February 2019

OCA — Wed, 27 Feb 2019 13:52:55 GMT

←Older revision		Revision as of 13:52, 27 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qkg is ON HOLD	+	The entry 6qkg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6qkg" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2019 08:00:05 GMT

Protected "6qkg" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:00, 13 February 2019

OCA: New page: '''Unreleased structure''' The entry 6qkg is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Feb 2019 08:00:03 GMT

New page: '''Unreleased structure''' The entry 6qkg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6qkg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]