6qp0 - Revision history

OCA at 08:01, 10 April 2019

OCA — Wed, 10 Apr 2019 08:01:02 GMT

←Older revision		Revision as of 08:01, 10 April 2019
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp0 OCA], [http://pdbe.org/6qp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp0 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp0 OCA], [http://pdbe.org/6qp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp0 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp0 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Posttranscriptional RNA modifications occur in all domains of life. Modifications of anticodon bases are of particular importance for ribosomal decoding and proteome homeostasis. The Elongator complex modifies uridines in the wobble position and is highly conserved in eukaryotes. Despite recent insights into Elongator's architecture, the structure and function of its regulatory factor Kti12 have remained elusive. Here, we present the crystal structure of Kti12's nucleotide hydrolase domain trapped in a transition state of ATP hydrolysis. The structure reveals striking similarities to an O-phosphoseryl-tRNA kinase involved in the selenocysteine pathway. Both proteins employ similar mechanisms of tRNA binding and show tRNASec-dependent ATPase activity. In addition, we demonstrate that Kti12 binds directly to Elongator and that ATP hydrolysis is crucial for Elongator to maintain proper tRNA anticodon modification levels in vivo. In summary, our data reveal a hitherto uncharacterized link between two translational control pathways that regulate selenocysteine incorporation and affect ribosomal tRNA selection via specific tRNA modifications.
		+
		+	Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator.,Krutyholowa R, Hammermeister A, Zabel R, Abdel-Fattah W, Reinhardt-Tews A, Helm M, Stark MJR, Breunig KD, Schaffrath R, Glatt S Nucleic Acids Res. 2019 Mar 27. pii: 5420542. doi: 10.1093/nar/gkz190. PMID:30916349<ref>PMID:30916349</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6qp0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:33, 20 March 2019

OCA — Wed, 20 Mar 2019 08:33:42 GMT

←Older revision		Revision as of 08:33, 20 March 2019
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	<StructureSection load='6qp0' size='340' side='right'caption='[[6qp0]], [[Resolution\|resolution]] 2.41Å' scene=''>		<StructureSection load='6qp0' size='340' side='right'caption='[[6qp0]], [[Resolution\|resolution]] 2.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qp0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QP0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qp0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QP0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0070100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=209285 CBS 144.50])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp0 OCA], [http://pdbe.org/6qp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp0 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp0 OCA], [http://pdbe.org/6qp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp0 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp0 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cbs 144 50]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Glatt, S]]		[[Category: Glatt, S]]

OCA at 12:25, 13 March 2019

OCA — Wed, 13 Mar 2019 12:25:14 GMT

←Older revision		Revision as of 12:25, 13 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6qp0 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of Chaetomium thermophilum Kti12 in complex with ADP-AlF3==
-		+	<StructureSection load='6qp0' size='340' side='right'caption='[[6qp0]], [[Resolution\|resolution]] 2.41Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6qp0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QP0 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp0 OCA], [http://pdbe.org/6qp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp0 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp0 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Glatt, S]]
		+	[[Category: Krutyholowa, R]]
		+	[[Category: Cm5]]
		+	[[Category: Elongator]]
		+	[[Category: Elongator regulation. #elongator]]
		+	[[Category: Mcm5]]
		+	[[Category: Ncm5. elongator regulatory protein]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Trna]]
		+	[[Category: Trna modification]]

OCA at 13:53, 27 February 2019

OCA — Wed, 27 Feb 2019 13:53:49 GMT

←Older revision		Revision as of 13:53, 27 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qp0 is ON HOLD	+	The entry 6qp0 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6qp0" [edit=sysop:move=sysop]

OCA — Thu, 21 Feb 2019 05:25:48 GMT

Protected "6qp0" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:25, 21 February 2019

OCA: New page: '''Unreleased structure''' The entry 6qp0 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 21 Feb 2019 05:25:47 GMT

New page: '''Unreleased structure''' The entry 6qp0 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6qp0 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]