6qp7 - Revision history

OCA at 12:05, 24 January 2024

OCA — Wed, 24 Jan 2024 12:05:24 GMT

←Older revision		Revision as of 12:05, 24 January 2024
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	<StructureSection load='6qp7' size='340' side='right'caption='[[6qp7]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='6qp7' size='340' side='right'caption='[[6qp7]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qp7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QP7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qp7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QP7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.96Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sema2a, Sema-2a, CG4700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp7 OCA], [~~http~~://pdbe.org/6qp7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qp7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qp7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp7 OCA], [https://pdbe.org/6qp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qp7 RCSB], [https://www.ebi.ac.uk/pdbsum/6qp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SEM2A_DROME SEM2A_DROME]] Plays a role in growth cones guidance. Required for both proper adult behavior and survival. Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.<ref>PMID:8269517</ref>	+	[https://www.uniprot.org/uniprot/SEM2A_DROME SEM2A_DROME] Plays a role in growth cones guidance. Required for both proper adult behavior and survival. Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.<ref>PMID:8269517</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6qp7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6qp7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Semaphorin 3D structures\|Semaphorin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Harlos, K]]	+	[[Category: Harlos K]]
-	[[Category: Jones~~, E Y~~]]	+	[[Category: Jones EY]]
-	[[Category: Robinson~~, R A~~]]	+	[[Category: Robinson RA]]
-	[[Category: Rozbesky, D]]	+	[[Category: Rozbesky D]]
-	[[Category: Siebold, C]]	+	[[Category: Siebold C]]
-	~~[[Category: Axon guidance cue]]~~	+
-	~~[[Category: Cell signalling]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Semaphorin]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Signalling protein~~]]	+

OCA at 16:08, 28 August 2019

OCA — Wed, 28 Aug 2019 16:08:03 GMT

←Older revision		Revision as of 16:08, 28 August 2019
Line 3:		Line 3:
	<StructureSection load='6qp7' size='340' side='right'caption='[[6qp7]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='6qp7' size='340' side='right'caption='[[6qp7]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qp7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QP7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qp7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QP7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sema2a, Sema-2a, CG4700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp7 OCA], [http://pdbe.org/6qp7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp7 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp7 OCA], [http://pdbe.org/6qp7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp7 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SEM2A_DROME SEM2A_DROME]] Plays a role in growth cones guidance. Required for both proper adult behavior and survival. Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.<ref>PMID:8269517</ref>		[[http://www.uniprot.org/uniprot/SEM2A_DROME SEM2A_DROME]] Plays a role in growth cones guidance. Required for both proper adult behavior and survival. Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.<ref>PMID:8269517</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Semaphorin ligands and their plexin receptors are one of the major cell guidance factors that trigger localised changes in the cytoskeleton. Binding of semaphorin homodimer to plexin brings two plexins in close proximity which is a prerequisite for plexin signalling. This model appears to be too simplistic to explain the complexity and functional versatility of these molecules. Here, we determine crystal structures for all members of Drosophila class 1 and 2 semaphorins. Unlike previously reported semaphorin structures, Sema1a, Sema2a and Sema2b show stabilisation of sema domain dimer formation via a disulfide bond. Unexpectedly, our structural and biophysical data show Sema1b is a monomer suggesting that semaphorin function may not be restricted to dimers. We demonstrate that semaphorins can form heterodimers with members of the same semaphorin class. This heterodimerization provides a potential mechanism for cross-talk between different plexins and co-receptors to allow fine-tuning of cell signalling.
		+
		+	Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.,Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY Nat Commun. 2019 Aug 15;10(1):3691. doi: 10.1038/s41467-019-11683-y. PMID:31417095<ref>PMID:31417095</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6qp7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Harlos, K]]		[[Category: Harlos, K]]

OCA at 06:10, 21 August 2019

OCA — Wed, 21 Aug 2019 06:10:02 GMT

←Older revision		Revision as of 06:10, 21 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qp7 is ~~ON HOLD until Paper Publication~~	+	==Drosophila Semaphorin 2a==
-		+	<StructureSection load='6qp7' size='340' side='right'caption='[[6qp7]], [[Resolution\|resolution]] 1.96Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6qp7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QP7 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp7 OCA], [http://pdbe.org/6qp7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp7 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp7 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SEM2A_DROME SEM2A_DROME]] Plays a role in growth cones guidance. Required for both proper adult behavior and survival. Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.<ref>PMID:8269517</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Harlos, K]]
		+	[[Category: Jones, E Y]]
		+	[[Category: Robinson, R A]]
		+	[[Category: Rozbesky, D]]
		+	[[Category: Siebold, C]]
		+	[[Category: Axon guidance cue]]
		+	[[Category: Cell signalling]]
		+	[[Category: Developmental protein]]
		+	[[Category: Semaphorin]]
		+	[[Category: Signaling protein]]
		+	[[Category: Signalling protein]]

OCA at 13:54, 27 February 2019

OCA — Wed, 27 Feb 2019 13:54:02 GMT

←Older revision		Revision as of 13:54, 27 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qp7 is ON HOLD	+	The entry 6qp7 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6qp7" [edit=sysop:move=sysop]

OCA — Thu, 21 Feb 2019 05:26:22 GMT

Protected "6qp7" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 21 February 2019

OCA: New page: '''Unreleased structure''' The entry 6qp7 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 21 Feb 2019 05:26:21 GMT

New page: '''Unreleased structure''' The entry 6qp7 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6qp7 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]