6qp9 - Revision history

OCA at 12:05, 24 January 2024

OCA — Wed, 24 Jan 2024 12:05:28 GMT

←Older revision		Revision as of 12:05, 24 January 2024
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	<StructureSection load='6qp9' size='340' side='right'caption='[[6qp9]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='6qp9' size='340' side='right'caption='[[6qp9]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qp9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qp9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QP9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Sema1a, Dsema~~-~~I, Sema~~-~~1a, CG18405 ([http:/~~/~~www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp9 OCA], [~~http~~://pdbe.org/6qp9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qp9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qp9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp9 OCA], [https://pdbe.org/6qp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qp9 RCSB], [https://www.ebi.ac.uk/pdbsum/6qp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SEM1A_DROME SEM1A_DROME]] Involved in growth cone guidance through its role in axonal repulsion.<ref>PMID:15282266</ref> <ref>PMID:8269517</ref>	+	[https://www.uniprot.org/uniprot/SEM1A_DROME SEM1A_DROME] Involved in growth cone guidance through its role in axonal repulsion.<ref>PMID:15282266</ref> <ref>PMID:8269517</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6qp9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6qp9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Semaphorin 3D structures\|Semaphorin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Harlos, K]]	+	[[Category: Harlos K]]
-	[[Category: Jones~~, E Y~~]]	+	[[Category: Jones EY]]
-	[[Category: Robinson~~, R A~~]]	+	[[Category: Robinson RA]]
-	[[Category: Rozbesky, D]]	+	[[Category: Rozbesky D]]
-	[[Category: Siebold, C]]	+	[[Category: Siebold C]]
-	~~[[Category: Axon guidance cue]]~~	+
-	~~[[Category: Cell signalling]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Semaphorin]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Signalling protein~~]]	+

OCA at 16:08, 28 August 2019

OCA — Wed, 28 Aug 2019 16:08:11 GMT

←Older revision		Revision as of 16:08, 28 August 2019
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	<StructureSection load='6qp9' size='340' side='right'caption='[[6qp9]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='6qp9' size='340' side='right'caption='[[6qp9]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qp9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qp9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QP9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sema1a, Dsema-I, Sema-1a, CG18405 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp9 OCA], [http://pdbe.org/6qp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp9 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp9 OCA], [http://pdbe.org/6qp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp9 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SEM1A_DROME SEM1A_DROME]] Involved in growth cone guidance through its role in axonal repulsion.<ref>PMID:15282266</ref> <ref>PMID:8269517</ref>		[[http://www.uniprot.org/uniprot/SEM1A_DROME SEM1A_DROME]] Involved in growth cone guidance through its role in axonal repulsion.<ref>PMID:15282266</ref> <ref>PMID:8269517</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Semaphorin ligands and their plexin receptors are one of the major cell guidance factors that trigger localised changes in the cytoskeleton. Binding of semaphorin homodimer to plexin brings two plexins in close proximity which is a prerequisite for plexin signalling. This model appears to be too simplistic to explain the complexity and functional versatility of these molecules. Here, we determine crystal structures for all members of Drosophila class 1 and 2 semaphorins. Unlike previously reported semaphorin structures, Sema1a, Sema2a and Sema2b show stabilisation of sema domain dimer formation via a disulfide bond. Unexpectedly, our structural and biophysical data show Sema1b is a monomer suggesting that semaphorin function may not be restricted to dimers. We demonstrate that semaphorins can form heterodimers with members of the same semaphorin class. This heterodimerization provides a potential mechanism for cross-talk between different plexins and co-receptors to allow fine-tuning of cell signalling.
		+
		+	Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.,Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY Nat Commun. 2019 Aug 15;10(1):3691. doi: 10.1038/s41467-019-11683-y. PMID:31417095<ref>PMID:31417095</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6qp9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Harlos, K]]		[[Category: Harlos, K]]

OCA at 06:10, 21 August 2019

OCA — Wed, 21 Aug 2019 06:10:09 GMT

←Older revision		Revision as of 06:10, 21 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6qp9 ~~is ON HOLD until Paper Publication~~	+	==Drosophila Semaphorin 1a, extracellular domains 1-2==
-		+	<StructureSection load='6qp9' size='340' side='right'caption='[[6qp9]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~: ~~Rozbesky,~~ D., ~~Robinson, R~~.A., ~~Harlos, K~~., ~~Siebold~~, C., ~~Jones, E~~.Y.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6qp9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QP9 FirstGlance]. <br>
-	~~Description~~: ~~Drosophila Semaphorin 1a, extracellular domains 1-2~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp9 OCA], [http://pdbe.org/6qp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp9 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp9 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SEM1A_DROME SEM1A_DROME]] Involved in growth cone guidance through its role in axonal repulsion.<ref>PMID:15282266</ref> <ref>PMID:8269517</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Harlos, K]]		[[Category: Harlos, K]]
-	[[Category: ~~Robinson~~, ~~R.A~~]]	+	[[Category: Jones, E Y]]
-	[[Category: ~~Jones~~, ~~E.Y~~]]	+	[[Category: Robinson, R A]]
	[[Category: Rozbesky, D]]		[[Category: Rozbesky, D]]
	[[Category: Siebold, C]]		[[Category: Siebold, C]]
		+	[[Category: Axon guidance cue]]
		+	[[Category: Cell signalling]]
		+	[[Category: Developmental protein]]
		+	[[Category: Semaphorin]]
		+	[[Category: Signaling protein]]
		+	[[Category: Signalling protein]]

OCA at 13:54, 27 February 2019

OCA — Wed, 27 Feb 2019 13:54:06 GMT

←Older revision		Revision as of 13:54, 27 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qp9 is ON HOLD	+	The entry 6qp9 is ON HOLD until Paper Publication

	Authors: Rozbesky, D., Robinson, R.A., Harlos, K., Siebold, C., Jones, E.Y.		Authors: Rozbesky, D., Robinson, R.A., Harlos, K., Siebold, C., Jones, E.Y.

OCA: Protected "6qp9" [edit=sysop:move=sysop]

OCA — Thu, 21 Feb 2019 05:26:29 GMT

Protected "6qp9" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 21 February 2019

OCA: New page: '''Unreleased structure''' The entry 6qp9 is ON HOLD Authors: Rozbesky, D., Robinson, R.A., Harlos, K., Siebold, C., Jones, E.Y. Description: Drosophila Semaphorin 1a, extracellular do...

OCA — Thu, 21 Feb 2019 05:26:27 GMT

New page: '''Unreleased structure''' The entry 6qp9 is ON HOLD Authors: Rozbesky, D., Robinson, R.A., Harlos, K., Siebold, C., Jones, E.Y. Description: Drosophila Semaphorin 1a, extracellular do...

New page

'''Unreleased structure'''

The entry 6qp9 is ON HOLD

Authors: Rozbesky, D., Robinson, R.A., Harlos, K., Siebold, C., Jones, E.Y.

Description: Drosophila Semaphorin 1a, extracellular domains 1-2
[[Category: Unreleased Structures]]
[[Category: Harlos, K]]
[[Category: Robinson, R.A]]
[[Category: Jones, E.Y]]
[[Category: Rozbesky, D]]
[[Category: Siebold, C]]