6qpr - Revision history

OCA at 12:05, 24 January 2024

OCA — Wed, 24 Jan 2024 12:05:47 GMT

←Older revision		Revision as of 12:05, 24 January 2024
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	<StructureSection load='6qpr' size='340' side='right'caption='[[6qpr]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='6qpr' size='340' side='right'caption='[[6qpr]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qpr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_16457 Atcc 16457~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QPR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qpr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhizomucor_miehei Rhizomucor miehei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QPR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpr OCA], [~~http~~://pdbe.org/6qpr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qpr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qpr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpr OCA], [https://pdbe.org/6qpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qpr RCSB], [https://www.ebi.ac.uk/pdbsum/6qpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LIP_RHIMI LIP_RHIMI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6qpr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6qpr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lipase 3D Structures\|Lipase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 16457]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Triacylglycerol lipase~~]]	+	[[Category: Rhizomucor miehei]]
-	[[Category: Andersen, B]]	+	[[Category: Andersen B]]
-	[[Category: Baunsgaard, L]]	+	[[Category: Baunsgaard L]]
-	[[Category: Blagova, E]]	+	[[Category: Blagova E]]
-	[[Category: Dalal, S]]	+	[[Category: Dalal S]]
-	[[Category: Jorgensen~~, C I~~]]	+	[[Category: Jorgensen CI]]
-	[[Category: Moroz~~, O V~~]]	+	[[Category: Moroz OV]]
-	[[Category: Reiser, V]]	+	[[Category: Reiser V]]
-	[[Category: Saikia, R]]	+	[[Category: Saikia R]]
-	[[Category: Svendsen, A]]	+	[[Category: Svendsen A]]
-	[[Category: Wilson~~, K S]]~~	+	[[Category: Wilson KS]]
-	~~[[Category: Deletion mutant]]~~	+
-	~~[[Category: Fungal]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibition]]~~	+
-	~~[[Category: Intramolecular chaperone]]~~	+
-	~~[[Category: Lipase]]~~	+
-	~~[[Category: Propeptide~~]]	+

OCA at 07:35, 16 October 2019

OCA — Wed, 16 Oct 2019 07:35:29 GMT

←Older revision		Revision as of 07:35, 16 October 2019
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpr OCA], [http://pdbe.org/6qpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpr RCSB], [http://www.ebi.ac.uk/pdbsum/6qpr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpr OCA], [http://pdbe.org/6qpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpr RCSB], [http://www.ebi.ac.uk/pdbsum/6qpr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpr ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many proteins are synthesized as precursors, with propeptides playing a variety of roles such as assisting in folding or preventing them from being active within the cell. While the precise role of the propeptide in fungal lipases is not completely understood, it was previously reported that mutations in the propeptide region of the Rhizomucor miehei lipase have an influence on the activity of the mature enzyme, stressing the importance of the amino acid composition of this region. We here report two structures of this enzyme in complex with its propeptide, which suggests that the latter plays a role in the correct maturation of the enzyme. Most importantly, we demonstrate that the propeptide shows inhibition of lipase activity in standard lipase assays and propose that an important role of the propeptide is to ensure that the enzyme is not active during its expression pathway in the original host.
		+
		+	Novel Inhibitory Function of the Rhizomucor miehei Lipase Propeptide and Three-Dimensional Structures of Its Complexes with the Enzyme.,Moroz OV, Blagova E, Reiser V, Saikia R, Dalal S, Jorgensen CI, Bhatia VK, Baunsgaard L, Andersen B, Svendsen A, Wilson KS ACS Omega. 2019 Jun 7;4(6):9964-9975. doi: 10.1021/acsomega.9b00612. eCollection , 2019 Jun 30. PMID:31460089<ref>PMID:31460089</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6qpr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:37, 10 July 2019

OCA — Wed, 10 Jul 2019 06:37:42 GMT

←Older revision		Revision as of 06:37, 10 July 2019
Line 3:		Line 3:
	<StructureSection load='6qpr' size='340' side='right'caption='[[6qpr]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='6qpr' size='340' side='right'caption='[[6qpr]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qpr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16457 Atcc 16457]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 16457]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Triacylglycerol lipase]]		[[Category: Triacylglycerol lipase]]

OCA at 12:25, 13 March 2019

OCA — Wed, 13 Mar 2019 12:25:43 GMT

←Older revision		Revision as of 12:25, 13 March 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qpr is ~~ON HOLD until Paper Publication~~	+	==Rhizomucor miehei lipase propeptide complex, Ser95/Ile96 deletion mutant==
-		+	<StructureSection load='6qpr' size='340' side='right'caption='[[6qpr]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~Authors~~: ~~Moroz, O~~.V., ~~Blagova, E~~.~~, Reiser, V~~.~~, Saikia, R~~.~~, Dalal, S~~.~~, Jorgensen, C~~.I., ~~Baunsgaard~~, L., ~~Andersen, B~~., ~~Svendsen, A~~., ~~Wilson, K~~.S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6qpr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPR FirstGlance]. <br>
-	~~Description: Rhizomucor miehei lipase propeptide complex, Ser95~~/~~Ile96 deletion mutant~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
-	[[Category: ~~Dalal~~, S]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpr OCA], [http://pdbe.org/6qpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpr RCSB], [http://www.ebi.ac.uk/pdbsum/6qpr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpr ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Triacylglycerol lipase]]
		+	[[Category: Andersen, B]]
	[[Category: Baunsgaard, L]]		[[Category: Baunsgaard, L]]
-	[[Category: Wilson, K.S]]
-	[[Category: Svendsen, A]]
-	[[Category: Jorgensen, C.I]]
	[[Category: Blagova, E]]		[[Category: Blagova, E]]
-	[[Category: ~~Andersen~~, B]]	+	[[Category: Dalal, S]]
-	[[Category: Moroz, O.V]]	+	[[Category: Jorgensen, C I]]
		+	[[Category: Moroz, O V]]
	[[Category: Reiser, V]]		[[Category: Reiser, V]]
	[[Category: Saikia, R]]		[[Category: Saikia, R]]
		+	[[Category: Svendsen, A]]
		+	[[Category: Wilson, K S]]
		+	[[Category: Deletion mutant]]
		+	[[Category: Fungal]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibition]]
		+	[[Category: Intramolecular chaperone]]
		+	[[Category: Lipase]]
		+	[[Category: Propeptide]]

OCA at 13:54, 27 February 2019

OCA — Wed, 27 Feb 2019 13:54:48 GMT

←Older revision		Revision as of 13:54, 27 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qpr is ON HOLD	+	The entry 6qpr is ON HOLD until Paper Publication

	Authors: Moroz, O.V., Blagova, E., Reiser, V., Saikia, R., Dalal, S., Jorgensen, C.I., Baunsgaard, L., Andersen, B., Svendsen, A., Wilson, K.S.		Authors: Moroz, O.V., Blagova, E., Reiser, V., Saikia, R., Dalal, S., Jorgensen, C.I., Baunsgaard, L., Andersen, B., Svendsen, A., Wilson, K.S.

OCA: Protected "6qpr" [edit=sysop:move=sysop]

OCA — Thu, 21 Feb 2019 05:28:18 GMT

Protected "6qpr" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:28, 21 February 2019

OCA: New page: '''Unreleased structure''' The entry 6qpr is ON HOLD Authors: Moroz, O.V., Blagova, E., Reiser, V., Saikia, R., Dalal, S., Jorgensen, C.I., Baunsgaard, L., Andersen, B., Svendsen, A., W...

OCA — Thu, 21 Feb 2019 05:28:17 GMT

New page: '''Unreleased structure''' The entry 6qpr is ON HOLD Authors: Moroz, O.V., Blagova, E., Reiser, V., Saikia, R., Dalal, S., Jorgensen, C.I., Baunsgaard, L., Andersen, B., Svendsen, A., W...

New page

'''Unreleased structure'''

The entry 6qpr is ON HOLD

Authors: Moroz, O.V., Blagova, E., Reiser, V., Saikia, R., Dalal, S., Jorgensen, C.I., Baunsgaard, L., Andersen, B., Svendsen, A., Wilson, K.S.

Description: Rhizomucor miehei lipase propeptide complex, Ser95/Ile96 deletion mutant
[[Category: Unreleased Structures]]
[[Category: Dalal, S]]
[[Category: Baunsgaard, L]]
[[Category: Wilson, K.S]]
[[Category: Svendsen, A]]
[[Category: Jorgensen, C.I]]
[[Category: Blagova, E]]
[[Category: Andersen, B]]
[[Category: Moroz, O.V]]
[[Category: Reiser, V]]
[[Category: Saikia, R]]