6qpw - Revision history

OCA at 05:05, 11 April 2020

OCA — Sat, 11 Apr 2020 05:05:30 GMT

←Older revision		Revision as of 05:05, 11 April 2020
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	<SX load='6qpw' size='340' side='right' viewer='molstar' caption='[[6qpw]], [[Resolution\|resolution]] 3.30Å' scene=''>		<SX load='6qpw' size='340' side='right' viewer='molstar' caption='[[6qpw]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QPW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6QPW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0066330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD]), MCD1, PDS3, RHC21, SCC1, YDL003W, YD8119.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), SMC3, YJL074C, J1049 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), CTHT_0066330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0066330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD]), MCD1, PDS3, RHC21, SCC1, YDL003W, YD8119.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), SMC3, YJL074C, J1049 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), CTHT_0066330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpw OCA], [http://pdbe.org/6qpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpw RCSB], [http://www.ebi.ac.uk/pdbsum/6qpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6qpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpw OCA], [http://pdbe.org/6qpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpw RCSB], [http://www.ebi.ac.uk/pdbsum/6qpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:52, 6 March 2020

OCA — Fri, 06 Mar 2020 23:52:39 GMT

←Older revision		Revision as of 23:52, 6 March 2020
Line 1:		Line 1:

	==Structural basis of cohesin ring opening==		==Structural basis of cohesin ring opening==
-	<~~StructureSection~~ load='6qpw' size='340' side='right'caption='[[6qpw]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<SX load='6qpw' size='340' side='right' viewer='molstar' caption='[[6qpw]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6qpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPW FirstGlance]. <br>		<table><tr><td colspan='2'>[[6qpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPW FirstGlance]. <br>
Line 22:		Line 22:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
	[[Category: Chatd]]		[[Category: Chatd]]

OCA at 10:28, 26 February 2020

OCA — Wed, 26 Feb 2020 10:28:38 GMT

←Older revision		Revision as of 10:28, 26 February 2020
Line 3:		Line 3:
	<StructureSection load='6qpw' size='340' side='right'caption='[[6qpw]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6qpw' size='340' side='right'caption='[[6qpw]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qpw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0066330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD]), MCD1, PDS3, RHC21, SCC1, YDL003W, YD8119.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), SMC3, YJL074C, J1049 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), CTHT_0066330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpw OCA], [http://pdbe.org/6qpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpw RCSB], [http://www.ebi.ac.uk/pdbsum/6qpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpw OCA], [http://pdbe.org/6qpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpw RCSB], [http://www.ebi.ac.uk/pdbsum/6qpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SCC1_YEAST SCC1_YEAST]] Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate.<ref>PMID:9335333</ref> <ref>PMID:9335334</ref> <ref>PMID:9491073</ref> <ref>PMID:10403247</ref> [[http://www.uniprot.org/uniprot/SMC3_YEAST SMC3_YEAST]] Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.		[[http://www.uniprot.org/uniprot/SCC1_YEAST SCC1_YEAST]] Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate.<ref>PMID:9335333</ref> <ref>PMID:9335334</ref> <ref>PMID:9491073</ref> <ref>PMID:10403247</ref> [[http://www.uniprot.org/uniprot/SMC3_YEAST SMC3_YEAST]] Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Genome regulation requires control of chromosome organization by SMC-kleisin complexes. The cohesin complex contains the Smc1 and Smc3 subunits that associate with the kleisin Scc1 to form a ring-shaped complex that can topologically engage chromatin to regulate chromatin structure. Release from chromatin involves opening of the ring at the Smc3-Scc1 interface in a reaction that is controlled by acetylation and engagement of the Smc ATPase head domains. To understand the underlying molecular mechanisms, we have determined the 3.2-A resolution cryo-electron microscopy structure of the ATPgammaS-bound, heterotrimeric cohesin ATPase head module and the 2.1-A resolution crystal structure of a nucleotide-free Smc1-Scc1 subcomplex from Saccharomyces cerevisiae and Chaetomium thermophilium. We found that ATP-binding and Smc1-Smc3 heterodimerization promote conformational changes within the ATPase that are transmitted to the Smc coiled-coil domains. Remodeling of the coiled-coil domain of Smc3 abrogates the binding surface for Scc1, thus leading to ring opening at the Smc3-Scc1 interface.
		+
		+	The structure of the cohesin ATPase elucidates the mechanism of SMC-kleisin ring opening.,Muir KW, Li Y, Weis F, Panne D Nat Struct Mol Biol. 2020 Feb 17. pii: 10.1038/s41594-020-0379-7. doi:, 10.1038/s41594-020-0379-7. PMID:32066964<ref>PMID:32066964</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6qpw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
		+	[[Category: Chatd]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li, Y]]		[[Category: Li, Y]]

OCA at 08:06, 5 February 2020

OCA — Wed, 05 Feb 2020 08:06:33 GMT

←Older revision		Revision as of 08:06, 5 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qpw is ~~ON HOLD until Paper Publication~~	+	==Structural basis of cohesin ring opening==
-		+	<StructureSection load='6qpw' size='340' side='right'caption='[[6qpw]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6qpw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpw OCA], [http://pdbe.org/6qpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpw RCSB], [http://www.ebi.ac.uk/pdbsum/6qpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SCC1_YEAST SCC1_YEAST]] Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate.<ref>PMID:9335333</ref> <ref>PMID:9335334</ref> <ref>PMID:9491073</ref> <ref>PMID:10403247</ref> [[http://www.uniprot.org/uniprot/SMC3_YEAST SMC3_YEAST]] Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Li, Y]]
		+	[[Category: Muir, K W]]
		+	[[Category: Panne, D]]
		+	[[Category: Weis, F]]
		+	[[Category: Cell cycle]]
		+	[[Category: Chromatin]]
		+	[[Category: Cohesin]]
		+	[[Category: Genome segregation]]

OCA at 07:19, 2 October 2019

OCA — Wed, 02 Oct 2019 07:19:40 GMT

←Older revision		Revision as of 07:19, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qpw is ON HOLD	+	The entry 6qpw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 04:51, 3 April 2019

OCA — Wed, 03 Apr 2019 04:51:46 GMT

←Older revision		Revision as of 04:51, 3 April 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qpw is ON HOLD ~~until sometime in the future~~	+	The entry 6qpw is ON HOLD

	Authors:		Authors:

OCA: Protected "6qpw" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2019 13:55:00 GMT

Protected "6qpw" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:55, 27 February 2019

OCA: New page: '''Unreleased structure''' The entry 6qpw is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Feb 2019 13:54:59 GMT

New page: '''Unreleased structure''' The entry 6qpw is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6qpw is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]