6qrm - Revision history

OCA at 12:07, 24 January 2024

OCA — Wed, 24 Jan 2024 12:07:14 GMT

←Older revision		Revision as of 12:07, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6qrm' size='340' side='right'caption='[[6qrm]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6qrm' size='340' side='right'caption='[[6qrm]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qrm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QRM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QRM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qrm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QRM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qrm OCA], [~~http~~://pdbe.org/6qrm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qrm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qrm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qrm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qrm OCA], [https://pdbe.org/6qrm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qrm RCSB], [https://www.ebi.ac.uk/pdbsum/6qrm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qrm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. ~~[[http://www.uniprot.org/uniprot/AIFM3_HUMAN AIFM3_HUMAN]] Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.<ref>PMID:15764604</ref>~~	+	[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glycylpeptide N-tetradecanoyltransferase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Asensio, T]]	+	[[Category: Asensio T]]
-	[[Category: Dian, C]]	+	[[Category: Dian C]]
-	[[Category: Giglione, C]]	+	[[Category: Giglione C]]
-	[[Category: Meinnel, T]]	+	[[Category: Meinnel T]]
-	[[Category: Riviere~~, F B]]~~	+	[[Category: Riviere FB]]
-	~~[[Category: Acyltransferase]]~~	+
-	~~[[Category: Gcn5-related n-acetyltransferase]]~~	+
-	~~[[Category: Gnat]]~~	+
-	~~[[Category: Myristoyltransferase type1]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:46, 18 March 2020

OCA — Wed, 18 Mar 2020 09:46:55 GMT

←Older revision		Revision as of 09:46, 18 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qrm is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==HsNMT1 in complex with both MyrCoA and GNCFSKRRAA substrates==
		+	<StructureSection load='6qrm' size='340' side='right'caption='[[6qrm]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qrm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QRM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qrm OCA], [http://pdbe.org/6qrm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qrm RCSB], [http://www.ebi.ac.uk/pdbsum/6qrm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qrm ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. [[http://www.uniprot.org/uniprot/AIFM3_HUMAN AIFM3_HUMAN]] Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.<ref>PMID:15764604</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The promising drug target N-myristoyltransferase (NMT) catalyses an essential protein modification thought to occur exclusively at N-terminal glycines (Gly). Here, we present high-resolution human NMT1 structures co-crystallised with reactive cognate lipid and peptide substrates, revealing high-resolution snapshots of the entire catalytic mechanism from the initial to final reaction states. Structural comparisons, together with biochemical analysis, provide unforeseen details about how NMT1 reaches a catalytically competent conformation in which the reactive groups are brought into close proximity to enable catalysis. We demonstrate that this mechanism further supports efficient and unprecedented myristoylation of an N-terminal lysine side chain, providing evidence that NMT acts both as N-terminal-lysine and glycine myristoyltransferase.

-	~~Authors: Dian~~, C., ~~Riviere~~, F~~.B.~~, Asensio, T., ~~Giglione~~, C., ~~Meinnel~~, T.	+	High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.,Dian C, Perez-Dorado I, Riviere F, Asensio T, Legrand P, Ritzefeld M, Shen M, Cota E, Meinnel T, Tate EW, Giglione C Nat Commun. 2020 Feb 28;11(1):1132. doi: 10.1038/s41467-020-14847-3. PMID:32111831<ref>PMID:32111831</ref>

-	~~Description~~: ~~HsNMT1 in complex with both MyrCoA and GNCFSKRRAA substrates~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6qrm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Asensio, T]]		[[Category: Asensio, T]]
-	[[Category: Meinnel, T]]
	[[Category: Dian, C]]		[[Category: Dian, C]]
	[[Category: Giglione, C]]		[[Category: Giglione, C]]
-	[[Category: Riviere, F.B]]	+	[[Category: Meinnel, T]]
		+	[[Category: Riviere, F B]]
		+	[[Category: Acyltransferase]]
		+	[[Category: Gcn5-related n-acetyltransferase]]
		+	[[Category: Gnat]]
		+	[[Category: Myristoyltransferase type1]]
		+	[[Category: Transferase]]

OCA at 07:19, 2 October 2019

OCA — Wed, 02 Oct 2019 07:19:44 GMT

←Older revision		Revision as of 07:19, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qrm is ON HOLD	+	The entry 6qrm is ON HOLD until Paper Publication

	Authors: Dian, C., Riviere, F.B., Asensio, T., Giglione, C., Meinnel, T.		Authors: Dian, C., Riviere, F.B., Asensio, T., Giglione, C., Meinnel, T.

OCA at 04:15, 21 August 2019

OCA — Wed, 21 Aug 2019 04:15:25 GMT

←Older revision		Revision as of 04:15, 21 August 2019
Line 3:		Line 3:
	The entry 6qrm is ON HOLD		The entry 6qrm is ON HOLD

-	Authors: Dian, C., Riviere, F.B., Giglione, C., Meinnel, T.	+	Authors: Dian, C., Riviere, F.B., Asensio, T., Giglione, C., Meinnel, T.

	Description: HsNMT1 in complex with both MyrCoA and GNCFSKRRAA substrates		Description: HsNMT1 in complex with both MyrCoA and GNCFSKRRAA substrates
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Asensio, T]]
	[[Category: Meinnel, T]]		[[Category: Meinnel, T]]
	[[Category: Dian, C]]		[[Category: Dian, C]]
	[[Category: Giglione, C]]		[[Category: Giglione, C]]
	[[Category: Riviere, F.B]]		[[Category: Riviere, F.B]]

OCA: Protected "6qrm" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2019 13:59:18 GMT

Protected "6qrm" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:59, 27 February 2019

OCA: New page: '''Unreleased structure''' The entry 6qrm is ON HOLD Authors: Dian, C., Riviere, F.B., Giglione, C., Meinnel, T. Description: HsNMT1 in complex with both MyrCoA and GNCFSKRRAA substrat...

OCA — Wed, 27 Feb 2019 13:59:15 GMT

New page: '''Unreleased structure''' The entry 6qrm is ON HOLD Authors: Dian, C., Riviere, F.B., Giglione, C., Meinnel, T. Description: HsNMT1 in complex with both MyrCoA and GNCFSKRRAA substrat...

New page

'''Unreleased structure'''

The entry 6qrm is ON HOLD

Authors: Dian, C., Riviere, F.B., Giglione, C., Meinnel, T.

Description: HsNMT1 in complex with both MyrCoA and GNCFSKRRAA substrates
[[Category: Unreleased Structures]]
[[Category: Meinnel, T]]
[[Category: Dian, C]]
[[Category: Giglione, C]]
[[Category: Riviere, F.B]]