6qvc - Revision history

OCA at 05:08, 11 April 2020

OCA — Sat, 11 Apr 2020 05:08:43 GMT

←Older revision		Revision as of 05:08, 11 April 2020
Line 3:		Line 3:
	<SX load='6qvc' size='340' side='right' viewer='molstar' caption='[[6qvc]], [[Resolution\|resolution]] 4.00Å' scene=''>		<SX load='6qvc' size='340' side='right' viewer='molstar' caption='[[6qvc]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QVC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QVC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QVC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6QVC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qvb\|6qvb]], [[6qv6\|6qv6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qvb\|6qvb]], [[6qv6\|6qv6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLCN1, CLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLCN1, CLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qvc OCA], [http://pdbe.org/6qvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qvc RCSB], [http://www.ebi.ac.uk/pdbsum/6qvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qvc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6qvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qvc OCA], [http://pdbe.org/6qvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qvc RCSB], [http://www.ebi.ac.uk/pdbsum/6qvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qvc ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 23:55, 6 March 2020

OCA — Fri, 06 Mar 2020 23:55:16 GMT

←Older revision		Revision as of 23:55, 6 March 2020
Line 1:		Line 1:

	==CryoEM structure of the human ClC-1 chloride channel, CBS state 1==		==CryoEM structure of the human ClC-1 chloride channel, CBS state 1==
-	<~~StructureSection~~ load='6qvc' size='340' side='right'caption='[[6qvc]], [[Resolution\|resolution]] 4.00Å' scene=''>	+	<SX load='6qvc' size='340' side='right' viewer='molstar' caption='[[6qvc]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6qvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QVC FirstGlance]. <br>		<table><tr><td colspan='2'>[[6qvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QVC FirstGlance]. <br>
Line 27:		Line 27:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 12:46, 18 December 2019

OCA — Wed, 18 Dec 2019 12:46:02 GMT

←Older revision		Revision as of 12:46, 18 December 2019
Line 3:		Line 3:
	<StructureSection load='6qvc' size='340' side='right'caption='[[6qvc]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='6qvc' size='340' side='right'caption='[[6qvc]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qvc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QVC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QVC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qvb\|6qvb]], [[6qv6\|6qv6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qvb\|6qvb]], [[6qv6\|6qv6]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLCN1, CLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qvc OCA], [http://pdbe.org/6qvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qvc RCSB], [http://www.ebi.ac.uk/pdbsum/6qvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qvc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qvc OCA], [http://pdbe.org/6qvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qvc RCSB], [http://www.ebi.ac.uk/pdbsum/6qvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qvc ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 6qvc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6qvc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gourdon, P E]]		[[Category: Gourdon, P E]]

OCA at 11:26, 10 May 2019

OCA — Fri, 10 May 2019 11:26:10 GMT

←Older revision		Revision as of 11:26, 10 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~6qvc~~ is ~~ON HOLD~~	+	==CryoEM structure of the human ClC-1 chloride channel, CBS state 1==
		+	<StructureSection load='6qvc' size='340' side='right'caption='[[6qvc]], [[Resolution\|resolution]] 4.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qvc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QVC FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qvb\|6qvb]], [[6qv6\|6qv6]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qvc OCA], [http://pdbe.org/6qvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qvc RCSB], [http://www.ebi.ac.uk/pdbsum/6qvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qvc ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CLCN1_HUMAN CLCN1_HUMAN]] Thomsen and Becker disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLCN1_HUMAN CLCN1_HUMAN]] Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.<ref>PMID:12456816</ref> <ref>PMID:22521272</ref> <ref>PMID:26007199</ref> <ref>PMID:26502825</ref> <ref>PMID:26510092</ref> <ref>PMID:7951242</ref> <ref>PMID:8112288</ref> <ref>PMID:9122265</ref> <ref>PMID:9736777</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of ClC-1 is associated with myotonia congenita, a disease impairing muscle relaxation. Here, we present the cryo-electron microscopy (cryo-EM) structure of human ClC-1, uncovering an architecture reminiscent of that of bovine ClC-K and CLC transporters. The chloride conducting pathway exhibits distinct features, including a central glutamate residue ("fast gate") known to confer voltage-dependence (a mechanistic feature not present in ClC-K), linked to a somewhat rearranged central tyrosine and a narrower aperture of the pore toward the extracellular vestibule. These characteristics agree with the lower chloride flux of ClC-1 compared with ClC-K and enable us to propose a model for chloride passage in voltage-dependent CLC channels. Comparison of structures derived from protein studied in different experimental conditions supports the notion that pH and adenine nucleotides regulate ClC-1 through interactions between the so-called cystathionine-beta-synthase (CBS) domains and the intracellular vestibule ("slow gating"). The structure also provides a framework for analysis of mutations causing myotonia congenita and reveals a striking correlation between mutated residues and the phenotypic effect on voltage gating, opening avenues for rational design of therapies against ClC-1-related diseases.

-	~~Authors~~:	+	Structure of the human ClC-1 chloride channel.,Wang K, Preisler SS, Zhang L, Cui Y, Missel JW, Gronberg C, Gotfryd K, Lindahl E, Andersson M, Calloe K, Egea PF, Klaerke DA, Pusch M, Pedersen PA, Zhou ZH, Gourdon P PLoS Biol. 2019 Apr 25;17(4):e3000218. doi: 10.1371/journal.pbio.3000218., eCollection 2019 Apr. PMID:31022181<ref>PMID:31022181</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6qvc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gourdon, P E]]
		+	[[Category: Wang, K T]]
		+	[[Category: Zhou, Z H]]
		+	[[Category: Chloride channel]]
		+	[[Category: Clc1]]
		+	[[Category: Clcn1]]
		+	[[Category: Membrane protein]]

OCA: Protected "6qvc" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2019 10:23:21 GMT

Protected "6qvc" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:23, 13 March 2019

OCA: New page: '''Unreleased structure''' The entry 6qvc is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Mar 2019 10:23:20 GMT

New page: '''Unreleased structure''' The entry 6qvc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6qvc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]