6qxc - Revision history

OCA at 11:01, 14 June 2023

OCA — Wed, 14 Jun 2023 11:01:00 GMT

←Older revision		Revision as of 11:01, 14 June 2023
Line 1:		Line 1:

	==NMR structure of peptide 8, characterized by a trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E. coli ATCC and lost effect on P. aeruginosa.==		==NMR structure of peptide 8, characterized by a trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E. coli ATCC and lost effect on P. aeruginosa.==
-	<StructureSection load='6qxc' size='340' side='right'caption='[[6qxc~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6qxc' size='340' side='right'caption='[[6qxc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qxc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QXC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QXC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qxc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudis_bolbodactyla Pseudis bolbodactyla]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QXC FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PH6:(4S)-4-CYCLOHEXYL-L-PROLINE'>PH6</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PH6:(4S)-4-CYCLOHEXYL-L-PROLINE'>PH6</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qxc OCA], [~~http~~://pdbe.org/6qxc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qxc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qxc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qxc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qxc OCA], [https://pdbe.org/6qxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qxc RCSB], [https://www.ebi.ac.uk/pdbsum/6qxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qxc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brancaccio, D]]	+	[[Category: Pseudis bolbodactyla]]
-	[[Category: Carotenuto, A]]	+	[[Category: Brancaccio D]]
-	[[Category: Grieco, P]]	+	[[Category: Carotenuto A]]
-	[[Category: Merlino, F]]	+	[[Category: Grieco P]]
-	[[Category: Novellino, E]]	+	[[Category: Merlino F]]
-	~~[[Category: Amp]]~~	+	[[Category: Novellino E]]
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Antimicrobial]]~~	+
-	~~[[Category: Proline derivative]]~~	+
-	~~[[Category: Temporin~~]]	+

OCA at 06:21, 29 May 2019

OCA — Wed, 29 May 2019 06:21:59 GMT

←Older revision		Revision as of 06:21, 29 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qxc is ~~ON HOLD~~	+	==NMR structure of peptide 8, characterized by a trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E. coli ATCC and lost effect on P. aeruginosa.==
		+	<StructureSection load='6qxc' size='340' side='right'caption='[[6qxc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qxc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QXC FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PH6:(4S)-4-CYCLOHEXYL-L-PROLINE'>PH6</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qxc OCA], [http://pdbe.org/6qxc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qxc RCSB], [http://www.ebi.ac.uk/pdbsum/6qxc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qxc ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Previously, we identified a potent antimicrobial analogue of temporin L (TL), [Pro3]TL, in which glutamine at position 3 was substituted with proline. In this study, a series of analogues, where the position 3 was substituted with non-natural proline derivatives, was investigated for the correlation between the conformational properties of the compounds and their antibacterial, cytotoxic and hemolytic activities. Non-natural proline analogues with substituents at position 4 of the pyrrolidine ring were considered. Structure-activity relationship studies of these analogues were performed by means of antimicrobial and cytotoxicity assays along with circular dichroism (CD) and NMR spectroscopy analysis for selected compounds. The most promising peptides were additionally evaluated for their activity against some representative veterinary microbial strains to compare with those from human strains. We identified novel analogues with interesting properties that make them attractive lead compounds.

-	~~Authors: Brancaccio, D~~., ~~Carotenuto~~, A., ~~Merlino~~, F., ~~Grieco~~, P., ~~Novellino~~, E.	+	The Outcomes of Decorated-Prolines in Discovering Novel Antimicrobial Peptides from Temporin-L.,Grieco P, Buommino E, Carotenuto A, Antignano I, Bellavita R, Casciaro B, Loffredo MR, Merlino F, Novellino E, Mangoni ML, Nocera FP, Brancaccio D, Punzi P, Roversi D, Ingenito R, Bianchi E ChemMedChem. 2019 May 14. doi: 10.1002/cmdc.201900221. PMID:31087626<ref>PMID:31087626</ref>

-	~~Description: NMR structure of peptide 8~~, ~~characterized by~~ a ~~trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E~~. ~~coli ATCC and lost effect on P~~. ~~aeruginosa~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Novellino, E]]~~	+	<div class="pdbe-citations 6qxc" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Grieco, P~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Brancaccio, D]]		[[Category: Brancaccio, D]]
	[[Category: Carotenuto, A]]		[[Category: Carotenuto, A]]
		+	[[Category: Grieco, P]]
	[[Category: Merlino, F]]		[[Category: Merlino, F]]
		+	[[Category: Novellino, E]]
		+	[[Category: Amp]]
		+	[[Category: Antibiotic]]
		+	[[Category: Antimicrobial]]
		+	[[Category: Proline derivative]]
		+	[[Category: Temporin]]

OCA: Protected "6qxc" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2019 10:30:15 GMT

Protected "6qxc" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:30, 13 March 2019

OCA: New page: '''Unreleased structure''' The entry 6qxc is ON HOLD Authors: Brancaccio, D., Carotenuto, A., Merlino, F., Grieco, P., Novellino, E. Description: NMR structure of peptide 8, characteri...

OCA — Wed, 13 Mar 2019 10:30:13 GMT

New page: '''Unreleased structure''' The entry 6qxc is ON HOLD Authors: Brancaccio, D., Carotenuto, A., Merlino, F., Grieco, P., Novellino, E. Description: NMR structure of peptide 8, characteri...

New page

'''Unreleased structure'''

The entry 6qxc is ON HOLD

Authors: Brancaccio, D., Carotenuto, A., Merlino, F., Grieco, P., Novellino, E.

Description: NMR structure of peptide 8, characterized by a trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E. coli ATCC and lost effect on P. aeruginosa.
[[Category: Unreleased Structures]]
[[Category: Novellino, E]]
[[Category: Grieco, P]]
[[Category: Brancaccio, D]]
[[Category: Carotenuto, A]]
[[Category: Merlino, F]]