6qzi - Revision history

OCA at 12:11, 24 January 2024

OCA — Wed, 24 Jan 2024 12:11:50 GMT

←Older revision		Revision as of 12:11, 24 January 2024
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	<StructureSection load='6qzi' size='340' side='right'caption='[[6qzi]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6qzi' size='340' side='right'caption='[[6qzi]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qzi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qzi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QZI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~>, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~AQP7, AQP7L, AQP9 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzi OCA], [~~http~~://pdbe.org/6qzi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qzi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qzi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzi OCA], [https://pdbe.org/6qzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qzi RCSB], [https://www.ebi.ac.uk/pdbsum/6qzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>	+	[https://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6qzi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6qzi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aquaporin 3D structures\|Aquaporin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eltschkner, S]]	+	[[Category: Eltschkner S]]
-	[[Category: Lindkvist-Petersson, K]]	+	[[Category: Lindkvist-Petersson K]]
-	~~[[Category: Mare, S W.H de~~]]	+	[[Category: Venskutonyte R]]
-	[[Category: Venskutonyte, R]]	+	[[Category: De Mare SW-H]]
-	[[Category: ~~Aquaglyceroporin]]~~	+
-	~~[[Category: Glycerol channel]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 13:12, 25 December 2019

OCA — Wed, 25 Dec 2019 13:12:05 GMT

←Older revision		Revision as of 13:12, 25 December 2019
Line 3:		Line 3:
	<StructureSection load='6qzi' size='340' side='right'caption='[[6qzi]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6qzi' size='340' side='right'caption='[[6qzi]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qzi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qzi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QZI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AQP7, AQP7L, AQP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzi OCA], [http://pdbe.org/6qzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qzi RCSB], [http://www.ebi.ac.uk/pdbsum/6qzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzi OCA], [http://pdbe.org/6qzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qzi RCSB], [http://www.ebi.ac.uk/pdbsum/6qzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>		[[http://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The aquaglyceroporin 7 (AQP7) facilitates permeation of glycerol through cell membranes and is crucial for lipid metabolism in humans. Glycerol efflux in human adipocytes is controlled by translocation of AQP7 to the plasma membrane upon hormone stimulation. Here we present two X-ray structures of human AQP7 at 1.9 and 2.2 A resolution. The structures combined with molecular dynamics simulations suggest that AQP7 is a channel selective for glycerol and that glycerol may hamper water permeation through the channel. Moreover, the high resolution of the structures facilitated a detailed analysis of the orientation of glycerol in the pore, disclosing unusual positions of the hydroxyl groups. The data suggest that glycerol is conducted by a partly rotating movement through the channel. These observations provide a framework for understanding the basis of glycerol efflux and selectivity in aquaglyceroporins and pave the way for future design of AQP7 inhibitors.
		+
		+	Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7.,de Mare SW, Venskutonyte R, Eltschkner S, de Groot BL, Lindkvist-Petersson K Structure. 2019 Nov 29. pii: S0969-2126(19)30395-8. doi:, 10.1016/j.str.2019.11.011. PMID:31831212<ref>PMID:31831212</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6qzi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Eltschkner, S]]		[[Category: Eltschkner, S]]

OCA at 06:56, 27 November 2019

OCA — Wed, 27 Nov 2019 06:56:15 GMT

←Older revision		Revision as of 06:56, 27 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qzi ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of human Aquaporin 7 at 1.9 A resolution==
-		+	<StructureSection load='6qzi' size='340' side='right'caption='[[6qzi]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~Authors~~: ~~de Mare~~, S.W.-H., ~~Venskutonyte~~, R., ~~Eltschkner~~, S., ~~Lindkvist~~-~~Petersson, K~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6qzi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QZI FirstGlance]. <br>
-	~~Description: Crystal structure of human Aquaporin 7 at 1.9 A resolution~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzi OCA], [http://pdbe.org/6qzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qzi RCSB], [http://www.ebi.ac.uk/pdbsum/6qzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzi ProSAT]</span></td></tr>
-	~~[[Category~~: ~~De Mare~~, S.W.~~-H]~~]	+	</table>
-	[[Category: ~~Venskutonyte, R~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eltschkner, S]]		[[Category: Eltschkner, S]]
	[[Category: Lindkvist-Petersson, K]]		[[Category: Lindkvist-Petersson, K]]
		+	[[Category: Mare, S W.H de]]
		+	[[Category: Venskutonyte, R]]
		+	[[Category: Aquaglyceroporin]]
		+	[[Category: Glycerol channel]]
		+	[[Category: Membrane protein]]

OCA at 04:54, 23 October 2019

OCA — Wed, 23 Oct 2019 04:54:27 GMT

←Older revision		Revision as of 04:54, 23 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qzi is ON HOLD	+	The entry 6qzi is ON HOLD until Paper Publication

-	Authors:	+	Authors: de Mare, S.W.-H., Venskutonyte, R., Eltschkner, S., Lindkvist-Petersson, K.

-	Description:	+	Description: Crystal structure of human Aquaporin 7 at 1.9 A resolution
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: De Mare, S.W.-H]]
		+	[[Category: Venskutonyte, R]]
		+	[[Category: Eltschkner, S]]
		+	[[Category: Lindkvist-Petersson, K]]

OCA: Protected "6qzi" [edit=sysop:move=sysop]

OCA — Wed, 20 Mar 2019 06:12:15 GMT

Protected "6qzi" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:12, 20 March 2019

OCA: New page: '''Unreleased structure''' The entry 6qzi is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Mar 2019 06:12:13 GMT

New page: '''Unreleased structure''' The entry 6qzi is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6qzi is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]