6qzy - Revision history

OCA at 12:12, 24 January 2024

OCA — Wed, 24 Jan 2024 12:12:14 GMT

←Older revision		Revision as of 12:12, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6qzy' size='340' side='right'caption='[[6qzy]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='6qzy' size='340' side='right'caption='[[6qzy]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qzy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Jack_o'lantern Jack o'lantern~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6QZY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qzy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Omphalotus_olearius Omphalotus olearius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QZY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S~~-~~ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>~~, ~~<scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.61Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6qzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzy OCA], [~~http~~://pdbe.org/6qzy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qzy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qzy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzy OCA], [https://pdbe.org/6qzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qzy RCSB], [https://www.ebi.ac.uk/pdbsum/6qzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2R2JFI5_OMPOL A0A2R2JFI5_OMPOL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Jack o'lantern]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Naismith, J H~~]]	+	[[Category: Omphalotus olearius]]
-	[[Category: ~~Song, H~~]]	+	[[Category: Naismith JH]]
-	[[Category: ~~Peptide bond n-methyltransferase]]~~	+	[[Category: Song H]]
-	~~[[Category: Transferase~~]]	+

OCA at 07:01, 25 June 2020

OCA — Thu, 25 Jun 2020 07:01:53 GMT

←Older revision		Revision as of 07:01, 25 June 2020
Line 3:		Line 3:
	<StructureSection load='6qzy' size='340' side='right'caption='[[6qzy]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='6qzy' size='340' side='right'caption='[[6qzy]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qzy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QZY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qzy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Jack_o'lantern Jack o'lantern]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6QZY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzy OCA], [http://pdbe.org/6qzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qzy RCSB], [http://www.ebi.ac.uk/pdbsum/6qzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6qzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzy OCA], [http://pdbe.org/6qzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qzy RCSB], [http://www.ebi.ac.uk/pdbsum/6qzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzy ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The methylation of amide nitrogen atoms can improve the stability, oral availability, and cell permeability of peptide therapeutics. Chemical N-methylation of peptides is challenging. Omphalotin A is a ribosomally synthesized, macrocylic dodecapeptide with nine backbone N-methylations. The fungal natural product is derived from the precursor protein, OphMA, harboring both the core peptide and a SAM-dependent peptide alpha-N-methyltransferase domain. OphMA forms a homodimer and its alpha-N-methyltransferase domain installs the methyl groups in trans on the hydrophobic core dodecapeptide and some additional C-terminal residues of the protomers. These post-translational backbone N-methylations occur in a processive manner from the N- to the C-terminus of the peptide substrate. We demonstrate that OphMA can methylate polar, aromatic, and charged residues when these are introduced into the core peptide. Some of these amino acids alter the efficiency and pattern of methylation. Proline, depending on its sequence context, can act as a tunable stop signal. Crystal structures of OphMA variants have allowed rationalization of these observations. Our results hint at the potential to control this fungal alpha-N-methyltransferase for biotechnological applications.
		+
		+	Substrate Plasticity of a Fungal Peptide alpha-N-Methyltransferase.,Song H, Fahrig-Kamarauskaite JR, Matabaro E, Kaspar H, Shirran SL, Zach C, Pace A, Stefanov BA, Naismith JH, Kunzler M ACS Chem Biol. 2020 Jun 19. doi: 10.1021/acschembio.0c00237. PMID:32491837<ref>PMID:32491837</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6qzy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Jack o'lantern]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Naismith, J H]]		[[Category: Naismith, J H]]

OCA at 09:17, 1 April 2020

OCA — Wed, 01 Apr 2020 09:17:46 GMT

←Older revision		Revision as of 09:17, 1 April 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qzy ~~is ON HOLD until Paper Publication~~	+	==full length OphA V406P in complex with SAH==
-		+	<StructureSection load='6qzy' size='340' side='right'caption='[[6qzy]], [[Resolution\|resolution]] 1.61Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6qzy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QZY FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzy OCA], [http://pdbe.org/6qzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qzy RCSB], [http://www.ebi.ac.uk/pdbsum/6qzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzy ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Naismith, J H]]
		+	[[Category: Song, H]]
		+	[[Category: Peptide bond n-methyltransferase]]
		+	[[Category: Transferase]]

OCA: Protected "6qzy" [edit=sysop:move=sysop]

OCA — Wed, 20 Mar 2019 06:13:46 GMT

Protected "6qzy" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:13, 20 March 2019

OCA: New page: '''Unreleased structure''' The entry 6qzy is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Mar 2019 06:13:44 GMT

New page: '''Unreleased structure''' The entry 6qzy is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6qzy is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]