6r0h - Revision history

OCA at 08:27, 24 April 2019

OCA — Wed, 24 Apr 2019 08:27:23 GMT

←Older revision		Revision as of 08:27, 24 April 2019
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.		[[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Structure-based design and synthesis of two biphenyl-N-acyl-beta-d-glucopyranosylamine derivatives as well as their assessment as inhibitors of human liver glycogen phosphorylase (hlGPa, a pharmaceutical target for type 2 diabetes) is presented. X-ray crystallography revealed the importance of structural water molecules and that the inhibitory efficacy correlates with the degree of disturbance caused by the inhibitor binding to a loop crucial for the catalytic mechanism. The in silico-derived models of the binding mode generated during the design process corresponded very well with the crystallographic data.
		+
		+	High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-beta-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors.,Fischer T, Koulas SM, Tsagkarakou AS, Kyriakis E, Stravodimos GA, Skamnaki VT, Liggri PGV, Zographos SE, Riedl R, Leonidas DD Molecules. 2019 Apr 3;24(7). pii: molecules24071322. doi:, 10.3390/molecules24071322. PMID:30987252<ref>PMID:30987252</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6r0h" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:31, 10 April 2019

OCA — Wed, 10 Apr 2019 07:31:42 GMT

←Older revision		Revision as of 07:31, 10 April 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6r0h ~~is ON HOLD until Paper Publication~~	+	==Glycogen Phosphorylase b in complex with 3==
-		+	<StructureSection load='6r0h' size='340' side='right'caption='[[6r0h]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~: ~~Tsagkarakou, S~~.A., ~~Koulas~~, M.S., ~~Kyriakis~~, E., ~~Stravodimos~~, G.A., ~~Skamnaki~~, V.T., ~~Leonidas~~, D.D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6r0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R0H FirstGlance]. <br>
-	~~Description~~: ~~Glycogen~~ Phosphorylase b in ~~complex with 3~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JN2:3-(4-fluorophenyl)-~{N}-[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]benzamide'>JN2</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0h OCA], [http://pdbe.org/6r0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r0h RCSB], [http://www.ebi.ac.uk/pdbsum/6r0h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0h ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Phosphorylase]]
		+	[[Category: Koulas, M S]]
	[[Category: Kyriakis, E]]		[[Category: Kyriakis, E]]
-	[[Category: ~~Tsagkarakou~~, ~~S.A~~]]	+	[[Category: Leonidas, D D]]
-	[[Category: Skamnaki, V.T]]	+	[[Category: Skamnaki, V T]]
-	[[Category: ~~Leonidas~~, ~~D.D~~]]	+	[[Category: Stravodimos, G A]]
-	[[Category: ~~Koulas~~, M.S]]	+	[[Category: Tsagkarakou, S A]]
-	[[Category: ~~Stravodimos, G.A~~]]	+	[[Category: Transferase]]

OCA at 04:52, 3 April 2019

OCA — Wed, 03 Apr 2019 04:52:28 GMT

←Older revision		Revision as of 04:52, 3 April 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6r0h is ON HOLD	+	The entry 6r0h is ON HOLD until Paper Publication

	Authors: Tsagkarakou, S.A., Koulas, M.S., Kyriakis, E., Stravodimos, G.A., Skamnaki, V.T., Leonidas, D.D.		Authors: Tsagkarakou, S.A., Koulas, M.S., Kyriakis, E., Stravodimos, G.A., Skamnaki, V.T., Leonidas, D.D.

OCA: Protected "6r0h" [edit=sysop:move=sysop]

OCA — Wed, 20 Mar 2019 06:15:26 GMT

Protected "6r0h" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 20 March 2019

OCA: New page: '''Unreleased structure''' The entry 6r0h is ON HOLD Authors: Tsagkarakou, S.A., Koulas, M.S., Kyriakis, E., Stravodimos, G.A., Skamnaki, V.T., Leonidas, D.D. Description: Glycogen Pho...

OCA — Wed, 20 Mar 2019 06:15:24 GMT

New page: '''Unreleased structure''' The entry 6r0h is ON HOLD Authors: Tsagkarakou, S.A., Koulas, M.S., Kyriakis, E., Stravodimos, G.A., Skamnaki, V.T., Leonidas, D.D. Description: Glycogen Pho...

New page

'''Unreleased structure'''

The entry 6r0h is ON HOLD

Authors: Tsagkarakou, S.A., Koulas, M.S., Kyriakis, E., Stravodimos, G.A., Skamnaki, V.T., Leonidas, D.D.

Description: Glycogen Phosphorylase b in complex with 3
[[Category: Unreleased Structures]]
[[Category: Kyriakis, E]]
[[Category: Tsagkarakou, S.A]]
[[Category: Skamnaki, V.T]]
[[Category: Leonidas, D.D]]
[[Category: Koulas, M.S]]
[[Category: Stravodimos, G.A]]