6r0j - Revision history

OCA at 11:01, 14 June 2023

OCA — Wed, 14 Jun 2023 11:01:13 GMT

←Older revision		Revision as of 11:01, 14 June 2023
Line 1:		Line 1:

	==The N-terminal domain of rhomboid protease YqgP==		==The N-terminal domain of rhomboid protease YqgP==
-	<StructureSection load='6r0j' size='340' side='right'caption='[[6r0j~~]], [[NMR_Ensembles_of_Models \| 30 NMR models~~]]' scene=''>	+	<StructureSection load='6r0j' size='340' side='right'caption='[[6r0j]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R0J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R0J FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B4122_2383, B4122_4232, B4417_0943 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0j OCA], [https://pdbe.org/6r0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r0j RCSB], [https://www.ebi.ac.uk/pdbsum/6r0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0j ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0j OCA], [https://pdbe.org/6r0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r0j RCSB], [https://www.ebi.ac.uk/pdbsum/6r0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0j ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GLUP_BACSU GLUP_BACSU] Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter.<ref>PMID:15050034</ref> <ref>PMID:15616571</ref> <ref>PMID:15684070</ref> <ref>PMID:16621838</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Began, J]]	+	[[Category: Began J]]
-	[[Category: Strisovsky, K]]	+	[[Category: Strisovsky K]]
-	[[Category: Veverka, V]]	+	[[Category: Veverka V]]
-	~~[[Category: Bacillus subtili]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Metal binding]]~~	+
-	~~[[Category: Rhomboid protease~~]]	+

OCA at 15:25, 8 June 2021

OCA — Tue, 08 Jun 2021 15:25:40 GMT

←Older revision		Revision as of 15:25, 8 June 2021
Line 3:		Line 3:
	<StructureSection load='6r0j' size='340' side='right'caption='[[6r0j]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='6r0j' size='340' side='right'caption='[[6r0j]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6R0J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R0J FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B4122_2383, B4122_4232, B4417_0943 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B4122_2383, B4122_4232, B4417_0943 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6r0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0j OCA], [~~http~~://pdbe.org/6r0j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6r0j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6r0j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0j OCA], [https://pdbe.org/6r0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r0j RCSB], [https://www.ebi.ac.uk/pdbsum/6r0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0j ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6r0j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6r0j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rhomboid protease\|Rhomboid protease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:36, 3 June 2020

OCA — Wed, 03 Jun 2020 06:36:34 GMT

←Older revision		Revision as of 06:36, 3 June 2020
Line 3:		Line 3:
	<StructureSection load='6r0j' size='340' side='right'caption='[[6r0j]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='6r0j' size='340' side='right'caption='[[6r0j]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6R0J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R0J FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B4122_2383, B4122_4232, B4417_0943 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B4122_2383, B4122_4232, B4417_0943 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6r0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0j OCA], [http://pdbe.org/6r0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r0j RCSB], [http://www.ebi.ac.uk/pdbsum/6r0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0j OCA], [http://pdbe.org/6r0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r0j RCSB], [http://www.ebi.ac.uk/pdbsum/6r0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0j ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:47, 22 January 2020

OCA — Wed, 22 Jan 2020 16:47:53 GMT

←Older revision		Revision as of 16:47, 22 January 2020
Line 3:		Line 3:
	<StructureSection load='6r0j' size='340' side='right'caption='[[6r0j]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='6r0j' size='340' side='right'caption='[[6r0j]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R0J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R0J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0j OCA], [http://pdbe.org/6r0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r0j RCSB], [http://www.ebi.ac.uk/pdbsum/6r0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0j ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B4122_2383, B4122_4232, B4417_0943 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0j OCA], [http://pdbe.org/6r0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r0j RCSB], [http://www.ebi.ac.uk/pdbsum/6r0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0j ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Magnesium homeostasis is essential for life and depends on magnesium transporters, whose activity and ion selectivity need to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom, but their functions are largely elusive. Using proteomics, we find that Bacillus subtilis rhomboid protease YqgP interacts with the membrane-bound ATP-dependent processive metalloprotease FtsH and cleaves MgtE, the major high-affinity magnesium transporter in B. subtilis. MgtE cleavage by YqgP is potentiated in conditions of low magnesium and high manganese or zinc, thereby protecting B. subtilis from Mn(2+) /Zn(2+) toxicity. The N-terminal cytosolic domain of YqgP binds Mn(2+) and Zn(2+) ions and facilitates MgtE cleavage. Independently of its intrinsic protease activity, YqgP acts as a substrate adaptor for FtsH, a function that is necessary for degradation of MgtE. YqgP thus unites protease and pseudoprotease function, hinting at the evolutionary origin of rhomboid pseudoproteases such as Derlins that are intimately involved in eukaryotic ER-associated degradation (ERAD). Conceptually, the YqgP-FtsH system we describe here is analogous to a primordial form of "ERAD" in bacteria and exemplifies an ancestral function of rhomboid-superfamily proteins.
		+
		+	Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease.,Began J, Cordier B, Brezinova J, Delisle J, Hexnerova R, Srb P, Rampirova P, Kozisek M, Baudet M, Coute Y, Galinier A, Veverka V, Doan T, Strisovsky K EMBO J. 2020 Jan 13:e102935. doi: 10.15252/embj.2019102935. PMID:31930742<ref>PMID:31930742</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6r0j" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Began, J]]		[[Category: Began, J]]

OCA at 07:38, 8 January 2020

OCA — Wed, 08 Jan 2020 07:38:27 GMT

←Older revision		Revision as of 07:38, 8 January 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 6r0j is ~~ON HOLD~~	+	==The N-terminal domain of rhomboid protease YqgP==
-		+	<StructureSection load='6r0j' size='340' side='right'caption='[[6r0j]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R0J FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0j OCA], [http://pdbe.org/6r0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r0j RCSB], [http://www.ebi.ac.uk/pdbsum/6r0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0j ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Began, J]]
		+	[[Category: Strisovsky, K]]
		+	[[Category: Veverka, V]]
		+	[[Category: Bacillus subtili]]
		+	[[Category: Membrane protein]]
		+	[[Category: Metal binding]]
		+	[[Category: Rhomboid protease]]

OCA: Protected "6r0j" [edit=sysop:move=sysop]

OCA — Wed, 20 Mar 2019 06:15:45 GMT

Protected "6r0j" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 20 March 2019

OCA: New page: '''Unreleased structure''' The entry 6r0j is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Mar 2019 06:15:43 GMT

New page: '''Unreleased structure''' The entry 6r0j is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6r0j is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]