6r1l - Revision history

OCA at 12:13, 24 January 2024

OCA — Wed, 24 Jan 2024 12:13:13 GMT

←Older revision		Revision as of 12:13, 24 January 2024
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	<StructureSection load='6r1l' size='340' side='right'caption='[[6r1l]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6r1l' size='340' side='right'caption='[[6r1l]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Laclm Laclm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R1L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._cremoris_MG1363 Lactococcus lactis subsp. cremoris MG1363]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R1L FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>~~, ~~<scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.095Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~llmg_0323~~ (~~[https:~~/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=416870 LACLM])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r1l OCA], [https://pdbe.org/6r1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r1l RCSB], [https://www.ebi.ac.uk/pdbsum/6r1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r1l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r1l OCA], [https://pdbe.org/6r1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r1l RCSB], [https://www.ebi.ac.uk/pdbsum/6r1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r1l ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A2RI36_LACLM A2RI36_LACLM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Laclm~~]]	+	[[Category: Lactococcus lactis subsp. cremoris MG1363]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Reddem, R]]	+	[[Category: Reddem R]]
-	[[Category: Thunnissen~~, A M.W H]]~~	+	[[Category: Thunnissen AMWH]]
-	~~[[Category: Artificial metalloenzyme]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Padr family]]~~	+
-	~~[[Category: Phenanthroline]]~~	+
-	~~[[Category: Transcriptional regulator~~]]	+

OCA at 12:43, 13 October 2021

OCA — Wed, 13 Oct 2021 12:43:46 GMT

←Older revision		Revision as of 12:43, 13 October 2021
Line 3:		Line 3:
	<StructureSection load='6r1l' size='340' side='right'caption='[[6r1l]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6r1l' size='340' side='right'caption='[[6r1l]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r1l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R1L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6R1L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Laclm Laclm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R1L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6r1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r1l OCA], [~~http~~://pdbe.org/6r1l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6r1l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6r1l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6r1l ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">llmg_0323 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=416870 LACLM])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r1l OCA], [https://pdbe.org/6r1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r1l RCSB], [https://www.ebi.ac.uk/pdbsum/6r1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r1l ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We present an artificial metalloenzyme based on the transcriptional regulator LmrR that exhibits dynamics involving the positioning of its abiological metal cofactor. The position of the cofactor, in turn, was found to be related to the preferred catalytic reactivity, which is either the enantioselective Friedel-Crafts alkylation of indoles with beta-substituted enones or the tandem Friedel-Crafts alkylation/enantioselective protonation of indoles with alpha-substituted enones. The artificial metalloenzyme could be specialized for one of these catalytic reactions introducing a single mutation in the protein. The relation between cofactor dynamics and activity and selectivity in catalysis has not been described for natural enzymes and, to date, appears to be particular for artificial metalloenzymes.
		+
		+	Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme.,Villarino L, Chordia S, Alonso-Cotchico L, Reddem E, Zhou Z, Thunnissen AMWH, Marechal JD, Roelfes G ACS Catal. 2020 Oct 16;10(20):11783-11790. doi: 10.1021/acscatal.0c01619. Epub, 2020 Sep 18. PMID:33101759<ref>PMID:33101759</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6r1l" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Laclm]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Reddem, R]]		[[Category: Reddem, R]]

OCA at 09:19, 1 April 2020

OCA — Wed, 01 Apr 2020 09:19:06 GMT

←Older revision		Revision as of 09:19, 1 April 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6r1l is ~~ON HOLD~~	+	==Crystal structure of LmrR with bound copper phenanthroline==
-		+	<StructureSection load='6r1l' size='340' side='right'caption='[[6r1l]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~: ~~Reddem~~, R., ~~Thunnissen~~, A.M.W.H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6r1l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R1L FirstGlance]. <br>
-	~~Description: Crystal structure of LmrR with bound copper phenanthroline~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r1l OCA], [http://pdbe.org/6r1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r1l RCSB], [http://www.ebi.ac.uk/pdbsum/6r1l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r1l ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Reddem, R]]		[[Category: Reddem, R]]
-	[[Category: Thunnissen, A.M.W.H]]	+	[[Category: Thunnissen, A M.W H]]
		+	[[Category: Artificial metalloenzyme]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Padr family]]
		+	[[Category: Phenanthroline]]
		+	[[Category: Transcriptional regulator]]

OCA: Protected "6r1l" [edit=sysop:move=sysop]

OCA — Wed, 20 Mar 2019 06:19:13 GMT

Protected "6r1l" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:19, 20 March 2019

OCA: New page: '''Unreleased structure''' The entry 6r1l is ON HOLD Authors: Reddem, R., Thunnissen, A.M.W.H. Description: Crystal structure of LmrR with bound copper phenanthroline [[Category: Unrel...

OCA — Wed, 20 Mar 2019 06:19:11 GMT

New page: '''Unreleased structure''' The entry 6r1l is ON HOLD Authors: Reddem, R., Thunnissen, A.M.W.H. Description: Crystal structure of LmrR with bound copper phenanthroline [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 6r1l is ON HOLD

Authors: Reddem, R., Thunnissen, A.M.W.H.

Description: Crystal structure of LmrR with bound copper phenanthroline
[[Category: Unreleased Structures]]
[[Category: Reddem, R]]
[[Category: Thunnissen, A.M.W.H]]