6r2n - Revision history

OCA at 12:13, 24 January 2024

OCA — Wed, 24 Jan 2024 12:13:42 GMT

←Older revision		Revision as of 12:13, 24 January 2024
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	<StructureSection load='6r2n' size='340' side='right'caption='[[6r2n]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6r2n' size='340' side='right'caption='[[6r2n]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r2n]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_56498 Atcc 56498~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R2N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6R2N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r2n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R2N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.596Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>GLK1, KLLA0C01155g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~28985 ATCC 56498])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Glucokinase Glucokinase]~~, ~~with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r2n OCA], [https://pdbe.org/6r2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r2n RCSB], [https://www.ebi.ac.uk/pdbsum/6r2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r2n ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6r2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r2n OCA], [~~http~~://pdbe.org/6r2n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6r2n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6r2n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6r2n ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HXKG_KLULA HXKG_KLULA]] Glukokinase specific for aldohexoses. Phosphorylates glucose and mannose, but not fructose.<ref>PMID:17573926</ref>	+	[https://www.uniprot.org/uniprot/HXKG_KLULA HXKG_KLULA] Glukokinase specific for aldohexoses. Phosphorylates glucose and mannose, but not fructose.<ref>PMID:17573926</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6r2n" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6r2n" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hexokinase 3D structures\|Hexokinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 56498]]~~	+	[[Category: Kluyveromyces lactis]]
-	~~[[Category: Glucokinase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Grudnik, P]]	+	[[Category: Grudnik P]]
-	[[Category: Wator, E]]	+	[[Category: Wator E]]
-	[[Category: Zak, K]]	+	[[Category: Zak K]]
-	~~[[Category: Kluyveromyces lacti]]~~	+
-	~~[[Category: Sugar metabolism]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:27, 30 September 2020

OCA — Wed, 30 Sep 2020 07:27:36 GMT

←Older revision		Revision as of 07:27, 30 September 2020
Line 3:		Line 3:
	<StructureSection load='6r2n' size='340' side='right'caption='[[6r2n]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6r2n' size='340' side='right'caption='[[6r2n]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r2n]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R2N OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6R2N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r2n]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_56498 Atcc 56498]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R2N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R2N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLK1, KLLA0C01155g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 ATCC 56498])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6r2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r2n OCA], [http://pdbe.org/6r2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r2n RCSB], [http://www.ebi.ac.uk/pdbsum/6r2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r2n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r2n OCA], [http://pdbe.org/6r2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r2n RCSB], [http://www.ebi.ac.uk/pdbsum/6r2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r2n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 56498]]
	[[Category: Glucokinase]]		[[Category: Glucokinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 05:59, 16 October 2019

OCA — Wed, 16 Oct 2019 05:59:49 GMT

←Older revision		Revision as of 05:59, 16 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6r2n is ~~ON HOLD~~	+	==Crystal structure of KlGlk1 glucokinase from Kluyveromyces lactis==
		+	<StructureSection load='6r2n' size='340' side='right'caption='[[6r2n]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6r2n]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R2N FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r2n OCA], [http://pdbe.org/6r2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r2n RCSB], [http://www.ebi.ac.uk/pdbsum/6r2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r2n ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HXKG_KLULA HXKG_KLULA]] Glukokinase specific for aldohexoses. Phosphorylates glucose and mannose, but not fructose.<ref>PMID:17573926</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glucose phosphorylating enzymes are crucial in the regulation of basic cellular processes, including metabolism and gene expression. Glucokinases and hexokinases provide a pool of phosphorylated glucose in an adenosine diphosphate (ADP)- and ATP-dependent manner to shape the cell metabolism. The glucose processing enzymes from Kluyveromyces lactis are poorly characterized despite the emerging contribution of this yeast strain to industrial and laboratory scale biotechnology. The first reports on K. lactis glucokinase (KlGlk1) positioned the enzyme as an essential component required for glucose signaling. Nevertheless, no biochemical and structural information was available until now. Here, we present the first crystal structure of KlGlk1 together with biochemical characterization, including substrate specificity and enzyme kinetics. Additionally, comparative analysis of the presented structure and the prior structures of lactis hexokinase (KlHxk1) demonstrates the potential transitions between open and closed enzyme conformations upon ligand binding.

-	~~Authors:~~ Zak, K., Wator, E., ~~Grudnik~~, P.	+	Crystal Structure of Kluyveromyces lactis Glucokinase (KlGlk1).,Zak KM, Kalinska M, Wator E, Kuska K, Krutyholowa R, Dubin G, Popowicz GM, Grudnik P Int J Mol Sci. 2019 Sep 28;20(19). pii: ijms20194821. doi: 10.3390/ijms20194821. PMID:31569356<ref>PMID:31569356</ref>

-	~~Description: Crystal structure~~ of ~~KlGlk1 glucokinase from Kluyveromyces lactis~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Zak, K~~]]	+	<div class="pdbe-citations 6r2n" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glucokinase]]
		+	[[Category: Large Structures]]
	[[Category: Grudnik, P]]		[[Category: Grudnik, P]]
	[[Category: Wator, E]]		[[Category: Wator, E]]
		+	[[Category: Zak, K]]
		+	[[Category: Kluyveromyces lacti]]
		+	[[Category: Sugar metabolism]]
		+	[[Category: Transferase]]

OCA: Protected "6r2n" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2019 05:13:35 GMT

Protected "6r2n" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:13, 27 March 2019

OCA: New page: '''Unreleased structure''' The entry 6r2n is ON HOLD Authors: Zak, K., Wator, E., Grudnik, P. Description: Crystal structure of KlGlk1 glucokinase from Kluyveromyces lactis [[Category:...

OCA — Wed, 27 Mar 2019 05:13:34 GMT

New page: '''Unreleased structure''' The entry 6r2n is ON HOLD Authors: Zak, K., Wator, E., Grudnik, P. Description: Crystal structure of KlGlk1 glucokinase from Kluyveromyces lactis [[Category:...

New page

'''Unreleased structure'''

The entry 6r2n is ON HOLD

Authors: Zak, K., Wator, E., Grudnik, P.

Description: Crystal structure of KlGlk1 glucokinase from Kluyveromyces lactis
[[Category: Unreleased Structures]]
[[Category: Zak, K]]
[[Category: Grudnik, P]]
[[Category: Wator, E]]