6r3d - Revision history

OCA at 12:14, 24 January 2024

OCA — Wed, 24 Jan 2024 12:14:11 GMT

←Older revision		Revision as of 12:14, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6r3d' size='340' side='right'caption='[[6r3d]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='6r3d' size='340' side='right'caption='[[6r3d]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r3d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R3D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6R3D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r3d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R3D FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=JQW:4~~-[~~6,7-bis(chloranyl)-~~1~~~{H}-indol-3-yl]pyrimidin-2-amine'>JQW</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[2vag\|2vag]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JQW:4-[6,7-bis(chloranyl)-1~{H}-indol-3-yl]pyrimidin-2-amine'>JQW</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Dual~~-~~specificity_kinase Dual~~-~~specificity kinase~~]~~, with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~2~~.7.12.1 2.7.12.1]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r3d OCA], [https://pdbe.org/6r3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r3d RCSB], [https://www.ebi.ac.uk/pdbsum/6r3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r3d ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6r3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r3d OCA], [~~http~~://pdbe.org/6r3d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6r3d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6r3d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6r3d ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>	+	[https://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>
		+
		+	==See Also==
		+	*[[Dual specificity protein kinase 3D structures\|Dual specificity protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dual-specificity kinase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Domovich, Y]]	+	[[Category: Domovich Y]]
-	[[Category: Livnah, O]]	+	[[Category: Livnah O]]
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Splicing]]~~	+
-	~~[[Category: Viral infection~~]]	+

OCA at 06:51, 8 April 2020

OCA — Wed, 08 Apr 2020 06:51:40 GMT

←Older revision		Revision as of 06:51, 8 April 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6r3d is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of di-phosphorylated human CLK1 in complex with 4-(6,7-dichloro-1H-indol-3-yl)pyrimidin-2-amine==
-		+	<StructureSection load='6r3d' size='340' side='right'caption='[[6r3d]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6r3d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R3D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R3D FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JQW:4-[6,7-bis(chloranyl)-1~{H}-indol-3-yl]pyrimidin-2-amine'>JQW</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vag\|2vag]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r3d OCA], [http://pdbe.org/6r3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r3d RCSB], [http://www.ebi.ac.uk/pdbsum/6r3d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r3d ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dual-specificity kinase]]
		+	[[Category: Large Structures]]
		+	[[Category: Domovich, Y]]
		+	[[Category: Livnah, O]]
		+	[[Category: Kinase]]
		+	[[Category: Signaling protein]]
		+	[[Category: Splicing]]
		+	[[Category: Viral infection]]

OCA: Protected "6r3d" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2019 05:15:42 GMT

Protected "6r3d" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:15, 27 March 2019

OCA: New page: '''Unreleased structure''' The entry 6r3d is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Mar 2019 05:15:40 GMT

New page: '''Unreleased structure''' The entry 6r3d is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6r3d is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]