6r3e - Revision history

OCA at 12:14, 24 January 2024

OCA — Wed, 24 Jan 2024 12:14:12 GMT

←Older revision		Revision as of 12:14, 24 January 2024
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	<StructureSection load='6r3e' size='340' side='right'caption='[[6r3e]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='6r3e' size='340' side='right'caption='[[6r3e]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R3E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6R3E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R3E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=96H:Triisopropanolamine'>96H</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.269Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6r3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r3e OCA], [~~http~~://pdbe.org/6r3e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6r3e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6r3e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6r3e ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=96H:Triisopropanolamine'>96H</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r3e OCA], [https://pdbe.org/6r3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r3e RCSB], [https://www.ebi.ac.uk/pdbsum/6r3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r3e ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN]] ICF syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10647011</ref> <ref>PMID:10555141</ref> <ref>PMID:10588719</ref> <ref>PMID:11102980</ref> <ref>PMID:15580563</ref>	+	[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] ICF syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10647011</ref> <ref>PMID:10555141</ref> <ref>PMID:10588719</ref> <ref>PMID:11102980</ref> <ref>PMID:15580563</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN]] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.<ref>PMID:16357870</ref> <ref>PMID:17303076</ref> <ref>PMID:18413740</ref> <ref>PMID:18567530</ref>	+	[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.<ref>PMID:16357870</ref> <ref>PMID:17303076</ref> <ref>PMID:18413740</ref> <ref>PMID:18567530</ref>
		+
		+	==See Also==
		+	*[[DNA methyltransferase 3D structures\|DNA methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Maso, T ~~Dal~~]]	+	[[Category: Dal Maso T]]
-	[[Category: Rondelet, G]]	+	[[Category: Rondelet G]]
-	[[Category: Wouters, J]]	+	[[Category: Wouters J]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Dnmt3b pwwp domain]]~~	+
-	~~[[Category: Histone binding]]~~	+
-	~~[[Category: Ligand]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:51, 8 April 2020

OCA — Wed, 08 Apr 2020 06:51:45 GMT

←Older revision		Revision as of 06:51, 8 April 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6r3e is ~~ON HOLD until Paper Publication~~	+	==Human DNMT3B PWWP domain in complex with triisopropanolamine==
-		+	<StructureSection load='6r3e' size='340' side='right'caption='[[6r3e]], [[Resolution\|resolution]] 2.27Å' scene=''>
-	~~Authors~~: ~~Rondelet~~, G., ~~Dal Maso~~, T., ~~Wouters~~, J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6r3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R3E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R3E FirstGlance]. <br>
-	~~Description~~: ~~Human DNMT3B PWWP domain~~ in ~~complex~~ with ~~triisopropanolamine~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=96H:Triisopropanolamine'>96H</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r3e OCA], [http://pdbe.org/6r3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r3e RCSB], [http://www.ebi.ac.uk/pdbsum/6r3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r3e ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN]] ICF syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10647011</ref> <ref>PMID:10555141</ref> <ref>PMID:10588719</ref> <ref>PMID:11102980</ref> <ref>PMID:15580563</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN]] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.<ref>PMID:16357870</ref> <ref>PMID:17303076</ref> <ref>PMID:18413740</ref> <ref>PMID:18567530</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Maso, T Dal]]
		+	[[Category: Rondelet, G]]
	[[Category: Wouters, J]]		[[Category: Wouters, J]]
-	[[Category: ~~Rondelet, G~~]]	+	[[Category: Beta barrel]]
-	[[Category: ~~Dal Maso, T~~]]	+	[[Category: Dnmt3b pwwp domain]]
		+	[[Category: Histone binding]]
		+	[[Category: Ligand]]
		+	[[Category: Transferase]]

OCA at 04:54, 3 April 2019

OCA — Wed, 03 Apr 2019 04:54:14 GMT

←Older revision		Revision as of 04:54, 3 April 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6r3e is ON HOLD	+	The entry 6r3e is ON HOLD until Paper Publication

	Authors: Rondelet, G., Dal Maso, T., Wouters, J.		Authors: Rondelet, G., Dal Maso, T., Wouters, J.

OCA: Protected "6r3e" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2019 05:15:45 GMT

Protected "6r3e" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:15, 27 March 2019

OCA: New page: '''Unreleased structure''' The entry 6r3e is ON HOLD Authors: Rondelet, G., Dal Maso, T., Wouters, J. Description: Human DNMT3B PWWP domain in complex with triisopropanolamine [[Catego...

OCA — Wed, 27 Mar 2019 05:15:43 GMT

New page: '''Unreleased structure''' The entry 6r3e is ON HOLD Authors: Rondelet, G., Dal Maso, T., Wouters, J. Description: Human DNMT3B PWWP domain in complex with triisopropanolamine [[Catego...

New page

'''Unreleased structure'''

The entry 6r3e is ON HOLD

Authors: Rondelet, G., Dal Maso, T., Wouters, J.

Description: Human DNMT3B PWWP domain in complex with triisopropanolamine
[[Category: Unreleased Structures]]
[[Category: Wouters, J]]
[[Category: Rondelet, G]]
[[Category: Dal Maso, T]]