6r4r - Revision history

OCA at 05:17, 11 April 2020

OCA — Sat, 11 Apr 2020 05:17:28 GMT

←Older revision		Revision as of 05:17, 11 April 2020
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	<SX load='6r4r' size='340' side='right' viewer='molstar' caption='[[6r4r]], [[Resolution\|resolution]] 3.40Å' scene=''>		<SX load='6r4r' size='340' side='right' viewer='molstar' caption='[[6r4r]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r4r]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R4R OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6R4R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r4r]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R4R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R4R FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3R1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3R1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r4r OCA], [http://pdbe.org/6r4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r4r RCSB], [http://www.ebi.ac.uk/pdbsum/6r4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r4r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r4r OCA], [http://pdbe.org/6r4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r4r RCSB], [http://www.ebi.ac.uk/pdbsum/6r4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r4r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:59, 6 March 2020

OCA — Fri, 06 Mar 2020 23:59:22 GMT

←Older revision		Revision as of 23:59, 6 March 2020
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	==Cryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril==		==Cryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril==
-	<~~StructureSection~~ load='6r4r' size='340' side='right'caption='[[6r4r]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<SX load='6r4r' size='340' side='right' viewer='molstar' caption='[[6r4r]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6r4r]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R4R FirstGlance]. <br>		<table><tr><td colspan='2'>[[6r4r]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R4R FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Bovin]]		[[Category: Bovin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 12:49, 18 December 2019

OCA — Wed, 18 Dec 2019 12:49:05 GMT

←Older revision		Revision as of 12:49, 18 December 2019
Line 3:		Line 3:
	<StructureSection load='6r4r' size='340' side='right'caption='[[6r4r]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='6r4r' size='340' side='right'caption='[[6r4r]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r4r]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R4R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r4r]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R4R FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r4r OCA], [http://pdbe.org/6r4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r4r RCSB], [http://www.ebi.ac.uk/pdbsum/6r4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r4r ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3R1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r4r OCA], [http://pdbe.org/6r4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r4r RCSB], [http://www.ebi.ac.uk/pdbsum/6r4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r4r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).		[[http://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High resolution structural information on amyloid fibrils is crucial for the understanding of their formation mechanisms and for the rational design of amyloid inhibitors in the context of protein misfolding diseases. The Src-homology 3 domain of phosphatidyl-inositol-3-kinase (PI3K-SH3) is a model amyloid system that plays a pivotal role in our basic understanding of protein misfolding and aggregation. Here, we present the atomic model of the PI3K-SH3 amyloid fibril with a resolution determined to 3.4 A by cryo-electron microscopy (cryo-EM). The fibril is composed of two intertwined protofilaments that create an interface spanning 13 residues from each monomer. The model comprises residues 1-77 out of 86 amino acids in total, with the missing residues located in the highly flexible C-terminus. The fibril structure allows us to rationalise the effects of chemically conservative point mutations as well as of the previously reported sequence perturbations on PI3K-SH3 fibril formation and growth.
		+
		+	Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy.,Roder C, Vettore N, Mangels LN, Gremer L, Ravelli RBG, Willbold D, Hoyer W, Buell AK, Schroder GF Nat Commun. 2019 Aug 21;10(1):3754. doi: 10.1038/s41467-019-11320-8. PMID:31434882<ref>PMID:31434882</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6r4r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bovin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Buell, A K]]		[[Category: Buell, A K]]

OCA at 15:38, 28 August 2019

OCA — Wed, 28 Aug 2019 15:38:55 GMT

←Older revision		Revision as of 15:38, 28 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6r4r ~~is ON HOLD~~	+	==Cryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril==
-		+	<StructureSection load='6r4r' size='340' side='right'caption='[[6r4r]], [[Resolution\|resolution]] 3.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6r4r]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R4R FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r4r OCA], [http://pdbe.org/6r4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r4r RCSB], [http://www.ebi.ac.uk/pdbsum/6r4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r4r ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Buell, A K]]
		+	[[Category: Gremer, L]]
		+	[[Category: Hoyer, W]]
		+	[[Category: Mangels, L N]]
		+	[[Category: Ravelli, R B.G]]
		+	[[Category: Roeder, C]]
		+	[[Category: Schroder, G F]]
		+	[[Category: Vettore, N]]
		+	[[Category: Willbold, D]]
		+	[[Category: Amyloid fibril]]
		+	[[Category: Protein fibril]]
		+	[[Category: Sh3 domain]]

OCA: Protected "6r4r" [edit=sysop:move=sysop]

OCA — Wed, 03 Apr 2019 04:56:55 GMT

Protected "6r4r" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:56, 3 April 2019

OCA: New page: '''Unreleased structure''' The entry 6r4r is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Apr 2019 04:56:54 GMT

New page: '''Unreleased structure''' The entry 6r4r is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6r4r is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]