6r6x - Revision history

OCA at 12:16, 24 January 2024

OCA — Wed, 24 Jan 2024 12:16:22 GMT

←Older revision		Revision as of 12:16, 24 January 2024
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	==Crystal structure of di-phosphorylated human CLK1 in complex with 5-(1-methyl-1H-indol-3-yl)pyrimidin-4-amine==		==Crystal structure of di-phosphorylated human CLK1 in complex with 5-(1-methyl-1H-indol-3-yl)pyrimidin-4-amine==
-	<StructureSection load='6r6x' size='340' side='right'caption='[[6r6x]]' scene=''>	+	<StructureSection load='6r6x' size='340' side='right'caption='[[6r6x]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R6X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6R6X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r6x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R6X FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6r6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r6x OCA], [~~http~~://pdbe.org/6r6x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6r6x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6r6x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6r6x ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JU8:5-(1-methylindol-3-yl)pyrimidin-4-amine'>JU8</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r6x OCA], [https://pdbe.org/6r6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r6x RCSB], [https://www.ebi.ac.uk/pdbsum/6r6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r6x ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>
		+
		+	==See Also==
		+	*[[Dual specificity protein kinase 3D structures\|Dual specificity protein kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Domovich Y]]		[[Category: Domovich Y]]
	[[Category: Livnah O]]		[[Category: Livnah O]]

OCA at 06:02, 6 May 2020

OCA — Wed, 06 May 2020 06:02:06 GMT

←Older revision		Revision as of 06:02, 6 May 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6r6x ~~is ON HOLD~~	+	==Crystal structure of di-phosphorylated human CLK1 in complex with 5-(1-methyl-1H-indol-3-yl)pyrimidin-4-amine==
-		+	<StructureSection load='6r6x' size='340' side='right'caption='[[6r6x]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R6X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R6X FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r6x OCA], [http://pdbe.org/6r6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r6x RCSB], [http://www.ebi.ac.uk/pdbsum/6r6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r6x ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Domovich Y]]
		+	[[Category: Livnah O]]

OCA: Protected "6r6x" [edit=sysop:move=sysop]

OCA — Wed, 03 Apr 2019 05:04:36 GMT

Protected "6r6x" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:04, 3 April 2019

OCA: New page: '''Unreleased structure''' The entry 6r6x is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Apr 2019 05:04:34 GMT

New page: '''Unreleased structure''' The entry 6r6x is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6r6x is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]