6r7o - Revision history

OCA at 12:16, 24 January 2024

OCA — Wed, 24 Jan 2024 12:16:45 GMT

←Older revision		Revision as of 12:16, 24 January 2024
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	<StructureSection load='6r7o' size='340' side='right'caption='[[6r7o]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='6r7o' size='340' side='right'caption='[[6r7o]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r7o]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6R7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r7o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R7O FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~STAG1~~, ~~SA1, SCC3 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.31Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6r7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7o OCA], [~~http~~://pdbe.org/6r7o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6r7o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6r7o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7o OCA], [https://pdbe.org/6r7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r7o RCSB], [https://www.ebi.ac.uk/pdbsum/6r7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN]] STAG1-related intellectual disability-facial dysmorphism-gastroesophageal reflux syndrome. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN] STAG1-related intellectual disability-facial dysmorphism-gastroesophageal reflux syndrome. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN]] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.	+	[https://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Gileadi O]]
-	[[Category: Gileadi, O]]	+	[[Category: Newman JA]]
-	[[Category: Newman~~, J A~~]]	+	[[Category: Katis VL]]
-	[[Category: Katis~~, V L~~]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Chromatid]]~~	+
-	~~[[Category: Cohesin]]~~	+
-	~~[[Category: Gene regulation]]~~	+
-	~~[[Category: Stromal antigen~~]]	+

OCA at 06:32, 19 August 2020

OCA — Wed, 19 Aug 2020 06:32:56 GMT

←Older revision		Revision as of 06:32, 19 August 2020
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	<StructureSection load='6r7o' size='340' side='right'caption='[[6r7o]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='6r7o' size='340' side='right'caption='[[6r7o]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r7o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7O OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6R7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r7o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R7O FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STAG1, SA1, SCC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STAG1, SA1, SCC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6r7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7o OCA], [http://pdbe.org/6r7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7o RCSB], [http://www.ebi.ac.uk/pdbsum/6r7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7o OCA], [http://pdbe.org/6r7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7o RCSB], [http://www.ebi.ac.uk/pdbsum/6r7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN]] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.		[[http://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN]] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cohesin subunit STAG2 has emerged as a recurrently inactivated tumor suppressor in human cancers. Using candidate approaches, recent studies have revealed a synthetic lethal interaction between STAG2 and its paralog STAG1 To systematically probe genetic vulnerabilities in the absence of STAG2, we have performed genome-wide CRISPR screens in isogenic cell lines and identified STAG1 as the most prominent and selective dependency of STAG2-deficient cells. Using an inducible degron system, we show that chemical genetic degradation of STAG1 protein results in the loss of sister chromatid cohesion and rapid cell death in STAG2-deficient cells, while sparing STAG2-wild-type cells. Biochemical assays and X-ray crystallography identify STAG1 regions that interact with the RAD21 subunit of the cohesin complex. STAG1 mutations that abrogate this interaction selectively compromise the viability of STAG2-deficient cells. Our work highlights the degradation of STAG1 and inhibition of its interaction with RAD21 as promising therapeutic strategies. These findings lay the groundwork for the development of STAG1-directed small molecules to exploit synthetic lethality in STAG2-mutated tumors.
		+
		+	STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.,van der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M Life Sci Alliance. 2020 May 28;3(7). pii: 3/7/e202000725. doi:, 10.26508/lsa.202000725. Print 2020 Jul. PMID:32467316<ref>PMID:32467316</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6r7o" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:40, 10 July 2019

OCA — Wed, 10 Jul 2019 06:40:44 GMT

←Older revision		Revision as of 06:40, 10 July 2019
Line 3:		Line 3:
	<StructureSection load='6r7o' size='340' side='right'caption='[[6r7o]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='6r7o' size='340' side='right'caption='[[6r7o]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r7o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r7o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R7O FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7o OCA], [http://pdbe.org/6r7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7o RCSB], [http://www.ebi.ac.uk/pdbsum/6r7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7o ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STAG1, SA1, SCC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7o OCA], [http://pdbe.org/6r7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7o RCSB], [http://www.ebi.ac.uk/pdbsum/6r7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 12:		Line 13:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA: Protected "6r7o" [edit=sysop:move=sysop]

OCA — Wed, 10 Apr 2019 07:32:13 GMT

Protected "6r7o" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:32, 10 April 2019

OCA: New page: ==Crystal structure of the central region of human cohesin subunit STAG1==
OCA — Wed, 10 Apr 2019 07:32:11 GMT

New page: ==Crystal structure of the central region of human cohesin subunit STAG1== <StructureSection load='6r7o' size='340' side='right'caption='6r7o, resolution 2.31Å' s...

New page

==Crystal structure of the central region of human cohesin subunit STAG1==
<StructureSection load='6r7o' size='340' side='right'caption='[[6r7o]], [[Resolution|resolution]] 2.31Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6r7o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R7O FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7o OCA], [http://pdbe.org/6r7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7o RCSB], [http://www.ebi.ac.uk/pdbsum/6r7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7o ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN]] STAG1-related intellectual disability-facial dysmorphism-gastroesophageal reflux syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN]] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
TOC
</StructureSection>
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Gileadi, O]]
[[Category: Newman, J A]]
[[Category: Katis, V L]]
[[Category: Chromatid]]
[[Category: Cohesin]]
[[Category: Gene regulation]]
[[Category: Stromal antigen]]