6r8e - Revision history

OCA at 06:13, 18 August 2021

OCA — Wed, 18 Aug 2021 06:13:53 GMT

←Older revision		Revision as of 06:13, 18 August 2021
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	==SC14 G-hairpin==		==SC14 G-hairpin==
-	<StructureSection load='6r8e' size='340' side='right'caption='[[6r8e]]' scene=''>	+	<StructureSection load='6r8e' size='340' side='right'caption='[[6r8e]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R8E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r8e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R8E FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r8e OCA], [https://pdbe.org/6r8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r8e RCSB], [https://www.ebi.ac.uk/pdbsum/6r8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r8e ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r8e OCA], [https://pdbe.org/6r8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r8e RCSB], [https://www.ebi.ac.uk/pdbsum/6r8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r8e ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We recently showed that Saccharomyces cerevisiae telomeric DNA can fold into an unprecedented pseudocircular G-hairpin (PGH) structure. However, the formation of PGHs in the context of extended sequences, which is a prerequisite for their function in vivo and their applications in biotechnology, has not been elucidated. Here, we show that despite its 'circular' nature, PGHs tolerate single-stranded (ss) protrusions. High-resolution NMR structure of a novel member of PGH family reveals the atomistic details on a junction between ssDNA and PGH unit. Identification of new sequences capable of folding into one of the two forms of PGH helped in defining minimal sequence requirements for their formation. Our time-resolved NMR data indicate a possibility that PGHs fold via a complex kinetic partitioning mechanism and suggests the existence of K+ ion-dependent PGH folding intermediates. The data not only provide an explanation of cation-type-dependent formation of PGHs, but also explain the unusually large hysteresis between PGH melting and annealing noted in our previous study. Our findings have important implications for DNA biology and nanotechnology. Overrepresentation of sequences able to form PGHs in the evolutionary-conserved regions of the human genome implies their functionally important biological role(s).
		+
		+	Insight into formation propensity of pseudocircular DNA G-hairpins.,Zivkovic ML, Gajarsky M, Bekova K, Stadlbauer P, Vicherek L, Petrova M, Fiala R, Rosenberg I, Sponer J, Plavec J, Trantirek L Nucleic Acids Res. 2021 Feb 26;49(4):2317-2332. doi: 10.1093/nar/gkab029. PMID:33524154<ref>PMID:33524154</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6r8e" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lenarcic~~ Zivkovic M]]	+	[[Category: Plavec, J]]
-	[[Category: ~~Plavec J~~]]	+	[[Category: Trantirek, L]]
-	[[Category: ~~Trantirek L~~]]	+	[[Category: Zivkovic, M Lenarcic]]
		+	[[Category: Dna]]
		+	[[Category: G-hairpin dna nmr spectroscopy structure dynamic]]

OCA at 11:05, 3 February 2021

OCA — Wed, 03 Feb 2021 11:05:31 GMT

←Older revision		Revision as of 11:05, 3 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6r8e is ~~ON HOLD~~	+	==SC14 G-hairpin==
-		+	<StructureSection load='6r8e' size='340' side='right'caption='[[6r8e]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R8E FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r8e OCA], [https://pdbe.org/6r8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r8e RCSB], [https://www.ebi.ac.uk/pdbsum/6r8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r8e ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lenarcic Zivkovic M]]
		+	[[Category: Plavec J]]
		+	[[Category: Trantirek L]]

OCA at 06:32, 20 January 2021

OCA — Wed, 20 Jan 2021 06:32:22 GMT

←Older revision		Revision as of 06:32, 20 January 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6r8e is ON HOLD ~~until Paper Publication~~	+	The entry 6r8e is ON HOLD

	Authors:		Authors:

OCA at 06:01, 11 March 2020

OCA — Wed, 11 Mar 2020 06:01:22 GMT

←Older revision		Revision as of 06:01, 11 March 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6r8e is ON HOLD	+	The entry 6r8e is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6r8e" [edit=sysop:move=sysop]

OCA — Wed, 10 Apr 2019 05:42:32 GMT

Protected "6r8e" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 10 April 2019

OCA: New page: '''Unreleased structure''' The entry 6r8e is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Apr 2019 05:42:31 GMT

New page: '''Unreleased structure''' The entry 6r8e is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6r8e is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]